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What is Histafed?

Histafed is an antihistamine and decongestant medication that is used to treat nasal congestion and sneezing. It can also be used to treat itching eyes and sinus congestion due to allergic reactions or the common cold. Histafed is also used for reasons not mentioned in this medication guide.

Side effects of Histafed

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, like hives, trouble breathing, and swelling of your lips, face, tongue, throat, or face.

Histafed can cause severe adverse effects. Stop using the drug and call your physician immediately in the event that you experience:

  • Severe dizziness;
  • Nervousness;
  • Sleep problems trouble sleeping
  • Hypertension (severe headache or pounding of your neck or ear).

Common adverse effects of histafed could include:

  • Dizziness, drowsiness;
  • Dry mouth the nose, mouth, or throat;
  • Constipation;
  • Blurred vision or
  • Being anxious or restless (especially when it comes to children).

This is not a comprehensive list of possible side effects, and others could happen. Consult your physician for advice regarding medical effects. You can report symptoms to the FDA at 1-800-FDA-1088.

Similar/related drugs

Prednisone, fluticasone nasal, cetirizine, loratadine, benadryl, diphenhydramine, and promethazine


Do not take the medicine to make your child restless. Misuse of this medicine could result in death for infants and young children.

Before taking this medication

You shouldn't apply Histafed if you are sensitive to pseudoephedrine or triprolidine.

Don't take Histafed if you've used an MAO inhibitor within the last 14 days. A potentially dangerous interaction with a drug could occur. MAO inhibitors are isocarboxazid, linezolid, and methyl blue injections of phenelzine and tranylcypromine, as well as other ones.

Ask your doctor or pharmacist for a recommendation on whether this medicine is suitable for you if you previously had:

  • Asthma or another breathing disorder such as emphysema, as well as chronic bronchitis;
  • Hypertension, cardiovascular disease;
  • glaucoma;
  • diabetes or
  • A thyroid condition.

How to take Histafed?

Take exactly as indicated on the label or as directed by your physician. The cold and cough medication is intended to be used for short periods of time until symptoms improve. Take measurements of liquid medicine using the supplied syringe or dosage-measuring device (not the kitchen spoon).

Always adhere to the directions on the medication label regarding administering cold or cough medication to children. Don't use the medicine solely to induce sleepiness in a child. Death can occur through the misapplication of cold or cough medicine to children who are very young.

Contact your physician if your symptoms don't improve after seven weeks of therapy, if you are suffering from a fever, headache, cough, or the appearance of a skin eruption.

If you are in need of an operation or other medical examination, inform the doctor or surgeon prior to the time of your appointment if you took this medication within the last couple of days. Place it in a cool, dry place far from heat and moisture.

Do I be concerned if I miss a dose?

Since the drug is prescribed for emergencies, you may not be on a regular dosing schedule. Do not miss any doses when it's time for the next dose. Do not take two doses in one go.

What will happen if I take excessively?

For medical emergencies, seek emergency medical attention or contact for help at the Poison HelplinE at 1-800-222-1222.

What should be avoided?

Avoid driving and other hazardous activities until you understand the effects of heat on your body. The way you react could be affected.

Talk to your doctor or pharmacist prior to using any other cold or cough medicines that may have similar components. Drinking alcohol can trigger certain adverse effects of triprolidine.

Interaction with other drugs

Consult a physician or pharmacist before taking other medications that could induce the feeling of drowsiness (such as opioids as well as sleep medications such as a muscle relaxer or medication to treat anxiety and seizures). There are many possible interactions that are not described here.