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Generic name: dextromethorphan and guaifenesin [DEX-troe-me-THOR-fan-and-gwye-FEN-e-sin]
Brand names: Adult Cough DM, Children Giltuss Cough and Chest Congestion, Children’s Delsym Cough+Chest Congest DM, Children’s Robitussin Cough and Chest, Children’s Robitussin Cough and Chest Congestion DM,… show all 99 brands
Combinations for the upper respiratory tract

What is G-Zyncof?

Dextromethorphan works as a cough suppressant. Guaifenesin works as an expectorant.G-Zyncof treats cough and chest congestion due to the common cold or allergies.Dextromethorphan does not treat a cough caused by smoking.This leaflet does not list all the brands or forms of medication that are available.G-Zyncof can be used in other ways not mentioned in this guide.

Side effects of G-Zyncof

If you experience symptoms indicative of an allergic reaction, such as hives, difficulty breathing or swelling of lips, face, tongue or throat - please seek medical assistance immediately.

G-Zyncof can cause serious side effects. G-Zyncof should be stopped immediately, and you should consult your doctor if:

  • Mood changes
  • Headache or severe
  • Feeling like you could pass out or dizziness;

G-zyncof side effects may include:

  • Dizziness, drowsiness;
  • Sleep problems (insomnia);
  • Diarrhoea;
  • Feeling nervous, restless, or anxious

There may be other side effects. Call your physician if experiencing side effects; otherwise call the FDA directly at 1-800-FDA-1088 to report it.


If you've taken an MAO-inhibitor in the last 14 days (such as isocarboxazid or linezolid), or if your symptoms are worsened by MAO-inhibitors, do not take this medication.

Before you take this drug

G-Zyncof should not be used if you've taken MAO inhibitors in the last 14 days. A dangerous medication interaction may occur. MAO inhibitors are isocarboxazid (linezolid), phenelzine (phenelzine injection), rasagiline (selegiline), and tranylcypromine.

If you suffer from:

  • A cough that produces mucus
  • Asthma, emphysema, or chronic lung disease.

Consult your doctor before taking this medication if you're pregnant or breastfeeding.This medication may contain phenylalanine. If you have phenylketonuria, check the label of your medication.

How to take G Zyncof?

Follow the directions on the label or those prescribed by your physician. Cold and cough medicines are only to be used for a short time until symptoms have cleared up.Follow the directions on the label when giving a cough or cold medication to a child. Never use cough and cold medicine to put a child to sleep.Measuring liquid medicine is important. Use the provided dosing device or a dose-measuring tool (not a spoon).It may be necessary to shake the liquid prior to measuring a dose. Please follow all the instructions on the label.Do not chew, crush, or break the extended-release tablet.The granules can be sprinkled directly on your tongue. Swallow immediately.While taking this medication, drink extra fluids in order to loosen congestion and lubricate the throat.If your symptoms don't improve within 7 days or you experience a rash or a headache, call your doctor.Tell the surgeon if you've taken the medicine in the last few days and if you are going to need any kind of surgery.Save and store away from heat and moisture at room temperature.

What happens if I miss the dose?

G-Zyncof can be used as needed, and you don't need to follow a schedule. If it is almost time for the next dose, skip any missed ones.Never take two doses in one go.

What happens if I overdose?

Contact 1-800-222-1222 immediately in case of poisonous exposure and for help or seek immediate medical care.

What should be avoided?

Do not drive or engage in hazardous activities until you have determined how G-Zyncof affects you. You may be unable to react.Alcohol consumption can have side effects when taken with this medication.Before using any other cold or cough medicines, ask your doctor or pharmacist if they contain similar ingredients.

Interaction with other drug

Use this medicine only if you are not taking any other medications that can cause drowsiness, slow breathing, or anxiety (such as an opioid, muscle relaxer, or medication for seizures).Before using this medication, ask your doctor or pharmacist if you also use any other medications, such as vitamins and herbal remedies. Certain medicines can have unwanted or harmful effects when taken together. This medication guide does not list all possible interactions.