What is Fluoxetine and olanzapine?
Fluoxetine belongs to the class of antidepressants known as selective serotonin reuptake inhibitors (SSRI). Olanzapine is an antipsychotic drug. A combination medicine called fluoxetine and olanzapine is used to treat depression due to bipolar disorder or manic depression. Sometimes, fluoxetine or olanzapine are prescribed after other medications fail. This medication guide does not list all possible uses of fluoxetine or olanzapine.
Side effects of Fluoxetine and olanzapine
If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives or skin rash; difficulty breathing or swelling of your lips, face, tongue, or throat. If you experience symptoms of a serious reaction to a drug, which can affect multiple parts of the body, seek medical attention. The symptoms may include: skin rash or hives; fever; swollen lymph glands; flu-like symptoms; unusual bruises; or jaundice. Long-term or high doses of fluoxetine or olanzapine may cause a serious disorder of movement that is not reversible. This can happen to women and older adults. If you experience uncontrollable movements in your arms, legs, lips, tongues, eyes, faces, or face, tell your doctor immediately. You should tell your doctor if any symptoms worsen or change, including: changes in mood or behavior, anxiety, panic attack, difficulty sleeping, or feeling impulsive, irritable, or agitated; hostile or aggressive; restless or hyperactive (mental or physical); more depressed; or having thoughts of suicide or harming yourself.
Side effects from olanzapine and fluoxetine can be serious. If you experience:
- Unusual bleeding or bruises
- Vision changes
- You may experience rapid or pounding pulses, fluttering of the chest, shortness of breath, and sudden dizziness.
- Dehydration symptoms include feeling very thirsty, hot, or unable to urinate. Other symptoms include heavy sweating or dry, hot skin.
- Severe nervous system reaction: very stiff (rigid muscles), high fever, sweating and confusion, rapid or uneven heartbeats. Tremors. Feeling like you may pass out.
- High sugar—increased thirst and urination; confusion; a fruity breath smell; increased hunger;
- Low sodium level: headache, confusion, slurred words, severe weakness and vomiting, lack of coordination, feeling unsteady,
- Low white blood cell count—fever and chills; mouth sores or skin sores; sore throats, coughs, difficulty breathing
If you experience symptoms of serotonin disorder, including: agitation or hallucinations; rapid heartbeat; muscle stiffness and twitching; and loss of coordination,
Some of the most common side effects associated with fluoxetine and olanzapine include:
- Drowsiness; blurred vision; dry mouth
- Weight gain due to increased appetite
- Feeling tired and having difficulty concentrating;
- You may experience swelling in your hands or feet.
- Tremor;
- Abnormal liver function or cholesterol levels.
There may be other side effects.Call your physician if experiencing side effects; to report side effects directly contact the FDA at 1-800-FDA-1088.
Similar/related drugs
Sertraline, Trazadone, Lexapro, Quetiapine, Lamotrigine, Citalopram, and Zoloft
Warnings
If you are taking pimozide, thioridazine, or any other medicine that contains fluoxetine or olanzapine but not in combination form, you should avoid using fluoxetine and olanzapine. Use fluoxetine or olanzapine only if you've taken an MAO-inhibitor in the last 14 days. Examples include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine. It is not recommended to use fluoxetine or olanzapine in older adults who have dementia-related psychosis. Anyone younger than 10 is not allowed to use fluoxetine or olanzapine. When first starting an antidepressant, some young people may have suicidal thoughts. Be alert to any changes in mood or symptoms. Notify your doctor of any new symptoms or symptoms that worsen.
Before you take this drug
This medicine should not be used if the patient is also taking pimozide, thioridazine, or other forms of fluoxetine (such as Prozac or Rapiflux) or olanzapine. You should not take this medication if you've taken an MAO-inhibitor in the last 14 days. A dangerous drug-drug interaction may occur. MAO inhibitors are isocarboxazid (linezolid), phenelzine (phenelzine injection), rasagiline (selegiline), methylene-blue injection, and tranylcypromine. You should not take MAO inhibitors within 5 weeks of stopping fluoxetine or olanzapine. It is not recommended to use fluoxetine or olanzapine in this way. They may increase the death risk for older adults who have dementia-related psychosis.
Inform your physician of any of the following issues:
- Alzheimer's disease:
- Liver disease
- Narrow-angle glaucoma;
- Heart problems
- High or low blood pressure
- Low white blood cell counts
- A seizure;
- Bleeding problems
- Breast cancer
- A stroke or "TIA", including "ministrokes"
- Diabetes is high cholesterol (or triglycerides);
- Bowel obstruction or severe constipation
- Electroconvulsive therapy (ECT)
- An enlarged prostrate
- Trouble swallowing
Make sure to tell your doctor if you are also taking stimulant medicines, opioids, herbal remedies, or medications for depression, mental illnesses, Parkinson’s disease, or migraine headaches. These drugs can interact with fluoxetine or olanzapine, causing a condition known as serotonin syndrome. When first starting an antidepressant, some young people may have suicidal thoughts. Regular visits to your doctor are a good way for you and your doctor to monitor the progress of your treatment. You or your family members should be aware of any changes in mood or symptoms. If you're pregnant, ask your doctor if taking an SSRI during late pregnancy can cause serious medical problems for the baby. You may experience a depression relapse if you stop using your antidepressant. If you fall pregnant, tell your doctor immediately. Do not start or stop using this medicine without consulting your doctor. You may find your name on a registry for pregnant women to monitor the effects of fluoxetine or olanzapine.
You may find it harder to get pregnant if you use this medication. Tell your doctor if the baby is exhibiting any of these symptoms: drowsiness or fussiness. You may also notice weight loss or abnormal muscle movements. Anyone younger than 10 is not allowed to use fluoxetine or olanzapine.
How to take Fluoxetine and olanzapine?
Read all the instructions or guides that come with your medication and follow the directions. Sometimes, your doctor will change the dose. Once prescribed, take your medication exactly as instructed. Do not abruptly stop taking fluoxetine or olanzapine; rather follow your physician's advice regarding dose reductions. Take your medicine every day at the same time, with or without eating. Your symptoms may not improve for up to four weeks. Continue to take the medication according to instructions, and inform your doctor if you do not see improvement in your symptoms. Store away from heat and moisture at room temperature.
What happens if I miss the dose?
If it is close to time for your next dose, take no action if a missed pill was missed.Never take two doses of the same medicine at once.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention.
What should be avoided?
Alcohol can cause certain side effects with fluoxetine and olanzapine. Do not drive or operate machinery until you are familiar with the effects of fluoxetine and/or olanzapine. You may become dizzy if you get up quickly from a seated or lying position. Dizziness and severe drowsiness may cause you to fall, break bones, or suffer other injuries.
Interaction with other drug
Fluoxetine or olanzapine may cause serious heart problems. You are at greater risk if you use other medications for heart problems, high blood pressure, HIV, malaria. These effects can be worsened by taking fluoxetine or olanzapine along with drugs that cause drowsiness or reduce breathing. Before taking an opioid, sleeping pill, muscle relaxer, cold or allergy medication, or medicine to treat anxiety or seizures, consult your doctor. Consult your doctor before using NSAIDs such as celecoxib, naproxen, diclofenac (Aleve), indomethacin (Indomethacin), meloxicam (Celebrex), and more. Using an NSAID along with fluoxetine or olanzapine can cause you to bleed and bruise easily. Several drugs can interact with fluoxetine and olanzapineIncluded below are both prescription and over-the-counter medicines, vitamins, and herbal products; this list does not reflect all possible interactions.Inform your doctor of all medications you are currently taking and those that you will stop or start using.
