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Generic name: Estradiol topical for skin use [ess-tra-DYE-ol TOP-ik al]

Drug Class: Estrogens as its therapeutic classification.

What is Estrasorb?

Estrasorb contains estradiol and is a topical emulsion. Estradiol, also known as estrogen or female hormones that control many bodily processes, is one form of estradiol.Estrasorb can be used after the menopause in order to decrease moderate to severe hot flushes. Normally, the ovaries stop producing estrogen between the ages of 45 and 55. Some women experience very unpleasant symptoms when estrogen levels start to drop, including feelings of warmth on the chest and face or feelings of sudden heat or sweating (also known as "hot flushes''). Some women will have mild symptoms and not require estrogens. Other women may experience more severe symptoms.Estrasorb can be used in other ways not mentioned in the medication guide.

Side effects of Estrasorb

If you experience any of the following symptoms of an Estrasorb allergy: difficulty breathing, hives, swelling in your lips, face, throat, tongue, or mouth, call 911 immediately.

If you experience any of the following symptoms, stop using Estrasorb immediately and contact your doctor.

  • Abnormal vaginal bleeding
  • A lump on your breast
  • Confusion is a problem with concentration or memory.
  • Heart attack symptoms include chest pain, pressure or pain that spreads to the jaw or shoulders, nausea, and sweating.
  • Liver problems: nausea, upper stomach discomfort, itching and tiredness, lack of appetite, black urine, a clay-colored stool, or jaundice
  • Signs of stroke: sudden numbness, weakness, or headache (mostly on one side), slurred or shaky speech, or problems with balance or vision;
  • Signs of a blood clot in the lungs: chest pain, sudden wheezing or coughing blood, rapid breathing;
  • Signs of a blood clot on your leg include pain, swelling, heat, and redness.

A child's skin absorbs topical estradiol if they come into close contact. If a child has swollen breasts or nipples, call your doctor.

Common Estrasorb side effects may include:

  • Breast pain
  • Headache;
  • Vaginal discharge or itching, changes to your period, or light bleeding
  • Hair loss on the scalp
  • Nausea, vomiting, bloating, and stomach cramps.

There may be other side effects. For medical advice on side effects, call your doctor. Report side effects by calling the FDA at 1-800-FDA-1088.


Estrasorb should be avoided if any of these conditions are present: history of a heart attack or stroke; a blood clot or bleeding disorder; liver disease or abnormal vaginal bleeds.If you are pregnant, do not use Estrasorb.Estradiol can increase the risk that you develop a condition that could lead to uterine carcinoma. If you experience any abnormal vaginal bleeding, call your doctor immediately.Avoid letting children touch the skin where Estrasorb has been applied. Topical estradiol can be absorbed by the skin. This may cause adverse effects for children who come into contact with Estrasorb.This medicine should not be taken to prevent strokes, heart attacks, or dementia. It may increase the risk that you will develop these diseases. The long-term use of estradiol may increase the risk of blood clots or breast cancer.

Similar/related drugs

Estradiol, Premarin, Estrace, Prempro, Norethindrone, and ethinyl esteradiol

Before you take this drug

Estrasorb should not be used if:

  • Undiagnosed abnormal bleeding in the vaginal area;
  • Breast, uterine, or hormone-dependent cancers;
  • A history of heart attacks, strokes, or blood clots (especially in the lungs or lower body);
  • Liver disease
  • A bleeding or blood-clotting disorder;
  • If you're pregnant or think that you might be pregnant
  • If you've ever experienced an allergic reaction when using estradiol topically,

Estradiol does not protect against heart disease, strokes, dementia, breast cancer, or heart attacks. In fact, it may increase the risk that you develop these diseases. Estradiol can also raise your risk of ovarian or uterine cancer. Speak to your doctor regarding your specific risks.

Tell your doctor about any of the following to ensure that Estrasorb will be safe for you:

  • Unusual vaginal bleeding
  • Heart disease
  • Asthma;
  • Epilepsy and other seizure disorders
  • Liver or kidney disease
  • Hereditary Angioedema
  • Endometriosis;
  • A thyroid condition;
  • Lupus;
  • Hypercalcemia is a condition where there are high calcium levels in the blood.
  • Migraines;
  • Gallbladder Disease
  • Risk factors for coronary heart disease include diabetes, obesity, high blood pressure, high cholesterol, and a history in the family.

Avoid using Estrasorb while pregnant.Estradiol may pass through breast milk, causing harm to a baby who is nursing. The medicine can also reduce breast milk production. Estrasorb should not be used if your baby is breastfed.

How to take Estrasorb?

Follow the instructions on your prescription label. Please follow all the instructions on the prescription label. Use this medication only as directed. Do not exceed the recommended dosage or use it for a longer period of time.Estradiol can increase the risk that you will develop a condition that could lead to uterine carcinoma. To help reduce this risk, your doctor might prescribe you progesterone. You should report any abnormal vaginal bleeding immediately.You should read all the information provided, including medication guides and instructions. If you have questions, ask your pharmacist or doctor.Estrasorb should only be applied to dry skin that is clean and unbroken. Apply Estrasorb only to clean, dry skin. Do not apply the medicine to the breasts.

To use Estrasorb topical emulsion:

  • Estrasorb should be applied while sitting comfortably. To apply the medication, you will need two foil pouches, unless you have been told otherwise by your doctor.
  • Place the pouch over your left thigh, with the opening facing your knee.
  • Use your fingers to push the Estrasorb emulsion from the pouch onto your thigh.
  • Rub the Estrasorb Emulsion for at least three minutes into both your left thigh and calves. Any excess medication should be rubbed onto your buttocks.
  • Apply the Estrasorb Emulsion using the above method to the right leg.

After applying the emulsion, wash your hands thoroughly with soap and warm water. Do not allow other people to touch the medicine. In this case, thoroughly wash the affected area with water and soap.Avoid letting children touch the skin where Estrasorb has been applied. The topical estradiol absorbed by the skin can lead to premature puberty for children who come into contact.You should have your doctor check on you regularly (every three to six months) in order to decide whether or not to continue the treatment. You should self-examine for lumps every month and get regular mammograms when using estradiol.You may have to temporarily stop using Estrasorb if you are going through medical testing or surgery, or you'll be in bed. You should let any doctor who treats you know that you use estradiol.Estrasorb should be stored at a temperature that is not too hot or humid.

What happens if I miss the dose?

If you forget to take a dose, use it as soon as possible. Skip the missed dose if you're more than 12 hours late. You should not add extra Estrasorb to the dose you missed.

What happens if I overdose?

Call the Poison Help Line at 1-800-222-1222 or seek emergency medical care. Overdose symptoms include nausea, vomiting, and stomach pain. Breast tenderness may also be present, as well as drowsiness or vaginal blood.

What should be avoided?

Apply Estrasorb before applying sunscreen.Avoid getting Estrasorb emulsion in your eyes. Rinse your eyes with water if this happens.The interaction between grapefruit and estradiol can have dangerous consequences. Talk to your doctor about the effects of using grapefruit.

Interaction with other drug

Estradiol topical may also interact with other drugs, such as prescription, over-the-counter, herbal, or vitamin products. Inform your healthcare providers of all medications you are taking and those you plan to take.