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Amlodipine and telmisartan

Generic name: amlodipine and telmisartan [am-LOE-de-peen-and-TEL-me-SAR-tan]
Name of the brand: Twynsta
Dosage format: oral tablet (10 mg–40 mg, 10 mg–80 mg; 5 mg–40 mg, 5 mg–80 mg)
Class of drug: angiotensin II inhibitors that block calcium channels.

What is Amlodipine and telmisartan?

Amlodipine can be described as an inhibitor of calcium channels. It is a calcium channel blocker that relaxes (widens) blood vessels and increases blood flow.Telmisartan can be described as an angiotensin II receptor antagonist that prevents blood vessels from narrowing. This reduces blood pressure as well as improves blood flow.Amlodipine and telmisartan are combination medicines that are used for treating excessive blood pressure (hypertension). Lowering blood pressure can reduce the risk of suffering a stroke or heart attack.Amlodipine and telmisartan can also be used to treat conditions that are not mentioned in this guide.

Side effects of Amlodipine and telmisartan

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergy, such as symptoms of hives, breathing difficulties, or swelling of your lips, face, and tongue,In rare instances, amlodipine and telmisartan may cause a condition that leads to the destruction of muscle tissue in the skeletal muscles and can lead to renal failure. Contact your physician immediately in the event of unexplained muscular discomfort or tenderness. You may also experience weakness, particularly if you suffer from fever, unusual fatigue, or dark urine.

Amlodipine and telmisartan could result in serious side effects. Consult your doctor immediately. If you suffer from:

  • A feeling of lightheadedness, as if you're about to pass out.
  • Breath shortness (even at moderate exertion) swelling and rapid weight gain.
  • New or worsening chest pain that isn't getting better or worse;
  • Beats of your heart or the sound of fluttering your chest
  • Muscle stiffness, tremors, or twitching;
  • High potassium, nausea, a slow or irregular pulse rate, weakening, and loss of motion.

Common adverse effects of amlodipine and telmisartan could include:

  • Swelling of your feet or hands
  • Rapid heartbeats or fast beats;
  • Dizziness, drowsiness;
  • Flushing (warmth, redness, warmth, or a tingly feeling);
  • Back pain
  • Stomach pain, nausea, diarrhoea, and stomach discomfort.

This isn't a complete list of possible side effects, and other side effects could occur. Contact your doctor to seek medical advice on adverse effects. If you experience any side negative effects to the FDA by calling 1-800-FDA-1088.


Do not take this medicine if expecting, and inform your doctor immediately in case you fall pregnant. This medicine can affect a newborn baby.If you suffer from diabetes, don't take amlodipine and telmisartan with any other medication that has the ingredient aliskiren (a blood pressure medication).

Prior to use this drug

It is not recommended to use amlodipine or telmisartan if you are intolerant of amlodipine (Norvasc) or telmisartan (Micardis).If you are diabetic, avoid taking amlodipine and telmisartan with any other medication containing Aliskiren (a blood pressure medication).It is also possible to stay clear of taking amlodipine or the telmisartan drug with Aliskiren in the event that you suffer from kidney problems.

Speak to your doctor if you were ever diagnosed with:

  • Kidney disease (or if you're taking dialysis)
  • The liver condition;
  • Coronary disease;
  • An electrolyte imbalance (such as a low level of magnesium or potassium within your blood)
  • If you're on an e-diet that is low in salt,

Do not take it when you are pregnant, and inform your doctor right away if you find yourself pregnant. Amlodipine and telmisartan could cause harm or even death to a baby who is not yet born if you are taking the medicine during the third or second trimester.It is not recommended to breastfeed while you take this medicine.This medication is not approved to be used by anyone less than 18 years old.

How to take Amlodipine and telmisartan?

Be sure to follow the instructions on your prescription label as well as read the drug documents and guides. Your doctor may alter the dosage. Follow the medication precisely as directed.It is possible to take this medication either with or without food in the exact same order every day.It is possible that you have high blood pressure when taking this medicine. Consult your physician if you have a fever, nausea, or diarrhea. Also, I have noticed that you are sweating more than normal.Your blood pressure will likely to be checked regularly. It is also possible that you will require frequent blood tests.Use this medication according to the directions, regardless of whether you are feeling well. A high blood pressure can have no signs. It is It is possible to require medications to reduce your blood pressure through your entire life.Keep the tablets at room temperature, far from heat and moisture. Store each tablet in a blister package until you are ready to take it.

Details on dosage

Usual Adult Dose for Hypertension:

Amlodipine, 5–10 mg; Telmisartan, 40–80 mg, taken orally, once a day
Maximum dosage: amlodipine 10 mg; telmisartan 80 mg, taken orally, once per day.
Correct volume and depletion of salt prior to initiating treatment.
Dose titration for the individual components is suggested prior to making the switch to this drug. Treatment can be initiated using this medication if it's likely that blood pressure cannot be controlled using monotherapy. The recommended dose to start treatment is amlodipine (5 mg/40 mg) twice a day.
Patients who suffer from any adverse reactions that are dose-limiting using amlodipine monotherapy (10 mg) can be changed to amlodipine 5 mg and telmisartan 40 mg daily to lower the dose of amlodipine without affecting the expected antihypertensive reaction.
Begin with a small amlodipine dosage for patients who are 65 years old or older. Initial treatment with this drug is not advised for patients who are 75 years old or older.
May increase dosage after two weeks.

What happens if I miss the dose?

Do not take the medicine for as long as you can. However, do not take any missed doses if you are close to the time of the next dose. Don't take two doses at a time.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Be careful not to get up too quickly from a lying or sitting position. You could be dizzy.Avoid using the potassium supplement or salt replacement except if your doctor has advised you to.

Interaction with other drugs

Discuss with your doctor any other medications you take, particularly:

  • Digoxin;
  • A diuretic, or "water pill";
  • Lithium;
  • Simvastatin ( zocor, vytorin);
  • Medicine to prevent organ transplant rejection—cyclosporine, tacrolimus;
  • An ace inhibitor--benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril;
  • These are nsaids (nonsteroidal anti-inflammatory drugs)--aspirin ibuprofen, aspirin (advil, motrin), naproxen (aleve) and celecoxib. Diclofenac, indomethacin and meloxicam and many others.

This list isn't complete. Other drugs can interact with amlodipine and telmisartan.They include over-the-counter and prescription medications, vitamins as well as herbal supplements.. Some interactions with drugs may not be listed here. are included here.




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