The Web Health


Elagolix Estradiol, and Norethindrone

Names of the generics: elagolix, estradiol, and norethindrone El-a-GOE’-lix, ES-traDYE-ol, and Nor-ETH-in-drone 

Name of the brand: Orianna
Dosage format: oral capsule (300 mg-1 mg-0.5 mg)
Classification of drugs: sex hormone combination

What are Elagolix Estradiol, and Norethindrone?

Elagolix and estradiol, as well as norethindrone (Oriahnn), are used to reduce bleeding during menstrual cycles in adult women suffering from uterine fibroids.Orianna is not recommended for women who are experiencing menopausal symptoms.Orianna could be used for other purposes that are not mentioned in this guide.

Side effects of Elagolix Estradiol, and Norethindrone

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, such as difficulty breathing, hives, or swelling of your lips, face, or tongue,

Orianna could increase the chance of having a heart attack, stroke, or blood clots. Stop taking this medicine and seek medical assistance promptly if you experience:

  • Chest pressure or pain radiating into your shoulder or jaw, nausea, sweating;
  • Inflammation, pain, warmth, or redness in the leg or arm;
  • Abrupt breathing shortness;
  • Suddenly numbness, weakness, or a severe headache;
  • Eye bulges, vision problems vision problems, bulging eyes
  • Difficulty speaking.

Elagolix and estradiol, as well as norethindrone, could result in serious adverse reactions. Should you experience any of the following, seek medical attention immediately:

  • Blood sugar levels are high, resulting in increased thirst, more frequent urine output, a dry mouth, and a fruity breath smell.
  • Any changes in mood or symptoms that are worsening, such as mood or behavioral changes, mood changes, depression, anxiety, thoughts of suicide, or harming yourself.
  • Issues with gallbladders or livers—loss of appetite vomiting, nausea, and stomach discomfort (upper right side) tiredness, swelling, bruising black stools, dark urine, and jaundice (yellowing of the eyes or skin).

This medication could lead to a permanent loss of hair.

Common negative side effects of elagolix estradiol, as well as norethindrone, could include:

  • Hot flashes;
  • Being tired;
  • Loss of hair (may cause permanent hair loss);
  • Headaches;
  • Menstrual irregularities.

This isn't a complete list of possible side effects, and other effects may also be present.Reach out to your physician in order to obtain medical advice regarding its effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.


Do not take this medicine if you're expecting.This medicine is for you if you suffer from high blood pressure that is not controlled, circulatory problems, heart disease (especially associated with diabetes), vaginal bleeding that is not diagnosed, liver disease, severe osteoporosis, migraines, smoking, being older than 35, or if you've ever suffered from an attack of the heart, stroke, blood clot, breast cancer, the uterus, cervix, or vagina.This medicine may increase your risk of suffering from blood clots, strokes, and heart attacks. The chance of having these effects is highest when you're older than 35, if you smoke, if you suffer from elevated cholesterol and diabetes, if you have uncontrolled blood pressure, or if you're obese.

Do not take this medication and seek medical attention immediately if you experience chest pain that has spread to your shoulder or jaw or suddenly a severe headache, difficulty with speech or vision, or pain or swelling on your leg.

Before you take this drug

You should not take elagolix, estradiol, or norethindrone in case you are allergic to elagolix, isradiol, or norethindrone. if you suffer from:

  • A history of a heart attack or stroke;
  • A blood clot within your lungs, heart, or legs;
  • Blood circulation issues;
  • A heart valve problem or problems with heart rhythm
  • Uncontrolled high blood pressure
  • Complications caused by diabetes that impact your kidneys, eyes, and nerves, as well as your blood vessels.
  • Extremely severe headaches (with aura) and aura, particularly when you are over 35 years old;
  • Gallbladder disorders;
  • A history of hormone-related cancer (such as cancers of the breast, uterus/cervix, and vagina);
  • Osteoporosis,
  • Abnormal vaginal bleeding that has not been examined by a doctor.

If you are taking Orianna, you could increase the risk of blood clot stroke as well as heart attack. You're more at risk if you suffer from diabetes, high blood pressure, high cholesterol levels, or are overweight.Smoking is a major contributor to the risk of stroke, blood clots, or heart attacks. You should not use this medication if you smoke or are more than 35 years old.Orianna can also lead to bone loss that could be permanent in a small amount. It's not clear whether this will increase the risk of bone fractures.Orianna is not an effective contraceptive medication. It does not stop pregnancy. It may be necessary to conduct a pregnancy test before beginning this treatment.Take this medication if you are expecting or planning to become pregnant. Orianna may increase the chance of miscarriage. Utilize effective birth control methods to stop pregnancies while taking this medicine and for a minimum of 1 week following the last dose.To avoid pregnancy when using Orianna, make use of a non-hormonal method of birth control, such as a condom, cervical cap, diaphragm, and contraceptive sponge. Do not use birth pills for control, injections, implants, skin patches, or vaginal rings.Take a break from Orianna and consult your doctor immediately if you suspect that you are pregnant.If you're pregnant, then your name might be added to an OB-GYN registry to keep track of your effects on the child.Orianna can alter your menstrual cycles (decreased or absence of bleeding), which can make it difficult to determine if you're expecting. Also, look out for other signs of pregnancy, such as the tenderness of your breasts, increased weight, and nausea.Inform your doctor if you have ever suffered from:

  • Bone problems, including broken bones;
  • Depression is depression, a mood disorder, suicidal ideation,
  • Jaundice (yellowing of the eyes or skin) due to birth control or pregnancy.

How to take Elagolix Estradiol, and Norethindrone?

Follow the directions on the prescription label and go through all medication guides or instructions sheets. Make sure you take the medication precisely as directed. It is not recommended to take Oriahnn for more than 24 months.This medication comes in various capsule colors. The white or yellow capsule is normally consumed in the early morning, while the white or blue capsule should be taken at night. Follow the instructions of your doctor for dosage extremely carefully.Use the medicine at the same time each day, either with or without eating.Your doctor might suggest that you take additional calcium and vitamin D while you take Orianna. Use these supplements only in the manner your doctor prescribes. Beware of iron supplements if you also consume calcium and vitamin D supplements.If you require surgery, inform your surgeon that you use this medication. It is possible that you will need to stop for a short period of time.Your blood pressure is likely to be monitored regularly. It is also possible to have scans to assess your bone mineral density prior to or during the treatment process with Orianna.Orianna can alter the results of certain tests. Be sure to inform any doctor who treats you that you're taking this medication.Keep it at room temperature, far from heat and moisture.Don't keep any capsules that are left over. Ask your pharmacist; you can find a drug take-back program. Do not flush any unused medication down the toilet.

Details on dosage

Usual Adult Dose for Uterine Fibroids:

One capsule, taken orally twice per day
The morning capsule contains the following ingredients: elagolix 300 mg, estradiol 1 mg, and norethindrone acetate 0.5 mg.
Evening capsule contains elagolix 300 mg.
Time of treatment: 24-months
Check for pregnancy before beginning therapy, or begin therapy within 7 days after the beginning of menses.
Take two capsules daily at roughly the same time every day.
The duration of treatment should be limited to a maximum of 24 months in order to avoid bone loss.
Use: To manage the issue of bleeding menstrual cycles that are heavy with uterine leiomyomas (fibroids) in women who are premenopausal.

What happens if I miss the dose?

Take the medication as quickly as you are able, but avoid your missed dose in case you are more than four hours behind on the dose. Don't use two doses at once.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help Line toll-free at 1-800-222-1222.Overdoses can trigger nausea, stomach pain, vomiting, breast tenderness, intense fatigue, and vaginal bleeding.

What should be avoided?

Don't smoke when taking this medicine, especially if you are over 35 years old.Grapefruit can be in contact with Rihanna and can cause undesirable negative side effects. Beware of using grapefruit-related products.

Interaction with other drugs

Discuss with your doctor all other medicines you take, including:

  • Thyroid medicine;
  • Cortisol replacement therapy

Other medications may cause a reaction to elagolix, estradiol, and norethindrone. These include prescription and over-the-counter medicines, vitamins, and herbal products. Discuss with your physician all the medicines you are currently taking as well as any medications you are about to start or stop taking.



Prescription only

Pregnancy & Lactation

CSA Schedule*
Related Drugs
Related Stories