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Estradiol (Injection)

Generic name: estradiol (injection) [ESS-tra-DYE-ol]
Brand names: Delestrogen, Depo-Estradiol
Dosage form: intramuscular solution (cypionate 5 mg/mL; valerate 10 mg/mL, 20 mg/mL and 40 mg/mL)
Drug class: estrogens

What is Estradiol (Infusion)?

Estradiol is a type of estrogen. It is a female hormone that regulates numerous processes within the body.It is also used for treating a lack of estrogen caused by ovarian failure or a data-type="auto" href="">hypogonadism/a>. The injection is used for a lack of estrogen caused by ovarian dysfunction, or hypogonadism.Certain forms of estradiol are given to men in order to treat symptoms of prostate cancer. Estradiol only treats the symptoms associated with prostate cancer,  not the cancer.This medication guide does not list all possible uses of estradiol.

Side effects of estradiol (Infusion)

If you experience any of the following symptoms of an allergy: difficulty breathing, hives, swelling in your lips, face, throat, or tongue

Estradiol may cause serious side effects. If you experience:

  • Heart attack symptoms: chest pain, pressure or pain in your shoulder or jaw, nausea, and sweating.
  • Signs of stroke: sudden numbness, weakness, or headache (especially on one side), slurred or shaky speech, or problems with balance or vision;
  • Signs of a blood clot include sudden vision loss, chest pain that stabs, shortness of breath, blood in the cough, or pain or heat in both legs.
  • You may experience swelling in the stomach or tenderness.
  • Jaundice
  • Memory problems, confusion, and unusual behavior
  • Unusual vaginal bleeding and pelvic pain
  • A lump on your breast,
  • High levels of calcium are accompanied by nausea, vomiting, and constipation. Other symptoms include muscle weakness, pain in the bones, fatigue, or increased thirst.

Estradiol side effects may include the following:

  • Breast pain
  • Headache;
  • Bleeding, vaginal irritation, or discharge;
  • Hair loss on the scalp
  • Nausea, vomiting, bloating, and stomach cramps.

There may be other side effects. For medical advice on side effects, call your doctor.Please contact the FDA by dialing their toll-free number 1-800-FDA-1088 if experiencing adverse side effects.

Similar/related drugs

alendronate, finasteride, estradiol, tamoxifen, fosamax, testosterone, and premarin


Estradiol should be avoided if: you are suffering from undiagnosed bleeding in the vaginal area; you suffer from liver disease; or you plan to undergo major surgical procedures. You also shouldn't use it if you have ever suffered a heart attack, stroke, blood clot, or breast, cervical, or vaginal cancer.Avoid using it if pregnant.Estradiol can increase the risk that you will develop a condition that may eventually lead to uterine cancer. Do not ignore any abnormal vaginal bleeding.Estradiol is not recommended for the prevention of strokes or dementia.

Before you take this drug

Estradiol should be avoided if:

  • Unusual vaginal bleeding not checked by your doctor
  • Liver disease
    An individual's history of heart attack, stroke or blood clot may raise risk factors for these problems.
  • A history of cancers of the breast, cervix, or uterus

Avoid estradiol during pregnancy. Inform your doctor immediately if you are pregnant while on treatment.

Estradiol increases your chances of having a stroke or heart attack. If you suffer from hypertension or diabetes, you may be at greater risk.This medicine can actually increase the risk of heart disease, stroke, or dementia.

If you've ever:

  • Heart disease
  • If you have liver disease or jaundice due to pregnancy, taking hormones, or being pregnant,
  • A thyroid condition;
  • Gallbladder Disease
  • Kidney disease
  • Asthma;
  • Epilepsy
  • Migraine headaches
  • Lupus;
  • Porphyria
  • Endometriosis or uterine fibroid tumors;
  • Calcium levels in the blood can be high or low.
  • Hereditary Angioedema

Estradiol can increase the risk of breast cancer, uterine cancer, or ovarian cancer. Speak to your doctor regarding this possibility.Estradiol may slow down the production of breast milk. Inform your doctor that you are breastfeeding.

How to take  Estradiol (Infusion)?

Read all the instructions or guides that come with your medication and follow all the directions. Follow the directions on your prescription label.Estradiol injections are given into the muscle. They can be administered every two to four weeks, depending on what condition is being treated. You can learn how to use this medication properly by consulting a healthcare professional.Please read and follow all instructions for use that come with your medication. If you do not understand the instructions, don't use estradiol.Whenever in doubt, consult with either your pharmacist or physician.Only prepare your injection when you're ready to administer it. If the color of your medicine changes or if it contains particles, do not use it. For new medication, call your pharmacist.

Estradiol can increase the risk that you will develop a condition that could lead to uterine carcinoma. A progestin may be prescribed by your doctor to lower the risk. Any unusual bleeding in the vaginal area should be reported immediately.You may have to temporarily stop taking estradiol if you are going through major surgery or if you will need a long period of bed rest. You should tell any doctor who treats you that you use estradiol.You should have your doctor check on you regularly to see if this is a treatment that should be continued. You should self-examine for lumps in your breasts every month and get regular mammograms when using estradiol.Protect against heat and moisture at room temperature.Only use a needle or syringe once, and place it in the "sharps container" to prevent punctures. Be sure to follow local or state laws on how you should dispose of the container. Keep it out of reach of pets and children.

What happens if I miss the dose?

If you are unable to keep your appointment, call your doctor and ask for further instructions.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Smoking is harmful. Estradiol can increase the risk of heart attacks, blood clots, and strokes.Avoid taking grapefruit products as they could potentially cause side effects. Use grapefruit-based products as little as possible.

Interaction with other drug

It is sometimes not safe to take certain drugs at the same time. Some medications can cause side effects that increase or decrease the effectiveness of another drug you are taking.Estradiol can be affected by other drugs, such as prescription or over-the-counter medications, vitamins, and herbal products. Inform your doctor of all the medicines you are taking and those that you stop or start using.



Prescription only

Pregnancy & Lactation

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