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Ertugliflozin and Metformin

Generic Name: [ER-too-gli-FLOE-zin-and-met-FOR-min]

Brand Name: Seguro Met Dosage form oral tablet (2-5-10; 2.5-50 mg; 7-15; 7.5-75)
Combinations of anti-diabetic drugs

What is Ertugliflozin and Metformin?

Ertugliflozin combined with metformin improves blood sugar control for adults who have type 2 diabetes mellitus. Metformin and ertugliflozin are not used to treat type 1 diabetes.This medication guide does not list all possible uses of metformin and ertugliflozin.

Side effects of Ertugliflozin and Metformin

If you experience any of the following symptoms of an allergy: difficulty breathing, hives, swelling in your lips, face, throat, or tongueIf any of these symptoms arise, seek medical assistance immediately.The symptoms can get worse very quickly.

Ertugliflozin or metformin can cause severe side effects. If you experience:

  • New pain or tenderness in the legs or feet, as well as sores or ulcers;
  • Little or no urine;
  • Lactic acidosis: unusual stomach pain, nausea, dizziness, or feeling cold.
  • Ketoacidosis is characterized by nausea and vomiting. Other symptoms include confusion, nausea, unusual sleepiness, or difficulty breathing.
  • Dehydration symptoms include feeling light-headed, dizzy, or weak.
  • Signs of a urinary tract infection include: pain or burning while urinating, an increase in urination and blood in the urine.

Some side effects are more common in elderly adults.

Side effects that may occur with ertugliflozin or metformin include:

  • Infection of the genital fungus
  • Stomach discomfort;
  • Nausea, vomiting, diarrhea, gas;
  • Headache weakness
  • Urinating more often than normal

There may be other side effects. For medical advice on side effects, call your doctor.Report side effects by calling the FDA at 1-800-FDA-1088.


If you suffer from severe kidney problems, are on dialysis, or have diabetes ketoacidosis, you should avoid using ertugliflozin.Ertugliflozin can increase the risk of lower-leg amputation. This is especially true if you've had an amputation in the past, have a foot wound, have heart disease, or have circulation issues.Ertugliflozin may cause severe infections of the vagina or penis. Seek medical attention immediately if there is any burning, itching, or discharge in your genital area or anywhere else, if the pain or tenderness increases, if the redness or swelling worsens, or if you feel unwell.You could develop lactic acidosis. This is a buildup of dangerous lactic acids in your blood. If you experience unusual pain in your muscles, difficulty breathing, nausea, dizziness, or fatigue, call your doctor.

Before you take this drug

This medicine should not be used if:

  • If you are living with severe kidney disease and/or on dialysis, or currently receiving it as treatment, or are on dialysis treatment.
  • Diabetic ketoacidosis: Call your doctor to get treated.

You may have to stop taking metformin and ertugliflozin temporarily if you are going to undergo an x-ray, CT scan, or any other type of test that uses a dye injected directly into your veins.Ertugliflozin can increase the risk of lower-leg amputation. This is especially true if you've had an amputation in the past, have a foot wound, suffer from heart disease, circulatory problems, or are suffering from nerve damage.

If you've ever:

  • Heart problems
    A diabetic ulcer, or an amputation.
  • You may have problems with your feet or legs, such as nerve or circulation issues.
  • Liver or kidney disease
  • High ketone levels are found in the blood or urine.
  • Other urination issues or bladder infections
  • Low blood pressure
  • Surgery for pancreatic problems
  • If you are a frequent alcohol drinker,
  • If you're on a diet low in salt,

Lactic acidosis is a buildup of dangerous lactic acids in the blood. You may have a higher risk if there are other conditions, such as a serious infection or chronic alcoholism. Consult your doctor to determine your level of risk.If you're pregnant, or if you get pregnant in the future, you should follow your doctor’s advice about this medication.This medicine should not be used during a pregnancy's second or third trimesterMetformin can stimulate ovulation and increase unintentional pregnancy risk in premenopausal women. Speak to your doctor to determine your risks.This medicine should not be used while breastfeeding.Anyone younger than the age of 18 is not allowed to use Ertugliflozin or Metformin.

How to take Ertugliflozin and Metformin?

Read all the instructions or guides that come with your medication and follow the directions. Sometimes, your doctor will change the dose. You must take the medication exactly as prescribed.Metformin and ertugliflozin work best when taken with food.If you have diarrhea or vomiting, if your food intake is lower than normal, or if you're perspiring, call your doctor.You will have to check your blood sugar often, and you may need to measure the amount of ketones in your urine. Metformin and ertugliflozin can lead to life-threatening ketoacidosis. Contact your doctor even if you have normal blood sugar. A urine test may show that there are ketones present.You might feel very hungry or dizzy. If you want to treat hyperglycemia quickly, consume or drink sugary foods or drinks (fruit juices, candy bars, crackers, or raisins).In the event of severe hypoglycemia, your doctor might prescribe a glucagon injectable kit. Make sure that your close family members or friends are familiar with how to administer this medication in case of an emergency.

Watch for symptoms of hyperglycemia, such as an increase in thirst or urine.Stress, illness, surgeries, physical activity, drinking alcohol, and skipping meals can all affect blood sugar levels. Consult your doctor before making any changes to your medication or dose schedule.Certain lab tests can produce unusual results when ertugliflozin is combined with metformin. Inform any doctor that treats you about your use of ertugliflozin or metformin.Ertugliflozin is just one part of an overall treatment plan that can include other things like diet, exercise, and weight management, as well as blood glucose testing and medical attention. You should follow your doctor’s advice.You may be prescribed extra vitamin B12 by your doctor. Only take the prescribed amount of Vitamin B12.Keep away from heat and moisture. Store at room temperature.

Details on dosage

Adult dose for diabetes type 2:

You can adjust the dose according to your current regimen.
First dose: Take 1 tablet twice daily.
For patients taking metformin, start with a tablet that contains ertugliflozin 2,5 mg plus one half of the total daily dose.
For patients taking ertugliflozin, start with a tablet that contains half the daily dose and 500mg of metformin.
For patients who have already been treated with metformin and ertugliflozin, start with the half-dose tablet of each.
Dose adjustment based on tolerability and effectiveness
Maximum dose daily: Ertugliflozin 15, mg; metformin 2000mg
Before starting therapy, it is important to correct the volume depletion.
Take metformin with food to minimize gastrointestinal symptoms.
This drug should not be used by patients who have diabetes type I, as it can increase the risk of diabetic ketoacidosis.
When used in conjunction with diet and exercise, it can improve the glycemic level of adults who have type II diabetes.

What happens if I miss the dose?

If you are almost due for the next dose, skip the missed one. Never take more than one dose at a time.

What happens if I overdose?

Call the Poison Help Line at 1-800-222-1222 or seek emergency medical care. An overdose can cause lactic acidosis.

Avoid this

It lowers blood sugar and may increase your risk of lactic a data-type="auto" href="">acidosis/a>. Alcohol lowers your blood sugar levels and can increase the risk of lactic acidosis.You may get dizzy if you stand up quickly from a seated or lying position.

Interaction with other drug

Your doctor might need to adjust your doses for any diabetes medications you take regularly when you stop or start taking metformin and ertugliflozin.Metformin and ertugliflozin can be affected by other drugs, such as prescription medicines and over-the counter medications, vitamins and herbal supplements. Inform your doctor of all the medicines you are currently taking and those that you will begin or stop taking.



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