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What is Voxelotor?

Voxelotor can be used to treat sickle cell diseases in children and adults who are at least 4 years old. Voxelotor can be used in conjunction with another medication called hydroxyurea. Voxelotor can also be employed for other purposes that are not covered in this guideline.

Side effects of Voxelotor

Contact a medical professional immediately. If you are experiencing symptoms that are warning signs of an allergic response, such as difficulty breathing, hives, or swelling of your lips, face, and tongue,

Common adverse effects of voxelotor could include:

  • Headache;
  • Fever;
  • Hives, rash, or
  • Stomach pain, nausea, diarrhea, and

This isn't a complete list of possible side effects, and others could happen. Consult your physician for advice regarding medical adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.


Only use according to the directions. Inform your doctor if you are taking other medicines or suffer from any other medical condition or allergies.

Before you start taking this medicine

Voxelotor is not a good choice if you have an allergy to it.

Inform your doctor if you were ever diagnosed with:

  • Liver issues.

It is unknown whether voxelotor could harm a newborn baby. Inform your doctor if you are expecting or planning to be pregnant. Don't breastfeed when using voxelotor and for a minimum of two weeks following your last dose.

How to take Voxelotor?

Follow the directions on the prescription label and go through all medication guides or instructions. Your doctor may alter the dosage. Make sure you take the medication precisely as prescribed. It is possible to take voxelotor at least daily, without or with meals. Tablets Take the tablet in its entirety and don't chew, crush, or break it.

Tablets to mix with oral suspension: Mix the tablets to make oral suspension in a room-temperature clear liquid like clear soda, water, or apple juice. clear electrolyte drinks, clear-flavoured drinks, or clear sports drinks prior to drinking them. Don't swallow the whole tablet; break, crush, or chew it to make oral suspension.  Your dosage requirements can change if you switch to a new brand, strength, or formulation of this medication. Make sure you are using only the medication the doctor has prescribed.

Voxelotor may influence the results of specific blood tests. Be sure to inform any doctor who treats you that you're taking Voxelotor.

You shouldn't stop taking Voxelotor unless you have a doctor's recommendation. Keep the tablets at room temperature, away from heat and moisture. Store the tablets in the original container and in the packaging or canister of preservative that absorbs moisture.

Details on dosage

Usual Adult Dose for Sickle Cell Anaemia:

1500 mg taken orally, once a day

The drug is available with or without the hydroxyurea.

Use: To treat sickle cell diseases.

Usual Paediatric Dose for Sickle Cell Anaemia:

From 4 to 12 years old: Weight 10 to less than 20kg: 600 mg every day
Weight between 20 and 40kg: 900 mg taken orally every day
Weight: 40 kg or more 1500 mg orally every day

12 years old or over: 1500 mg taken orally at least once per day.

The drug is available with or without the hydroxyurea.

Use: To treat sickle cell disease in patients who are 4 years old or older.

What happens If I miss a dose?

Don't miss the dose you missed, and take your next dose at your regular time. Do not take two doses at the same time.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided?

Follow the doctor's advice regarding any limitations on foods, drinks, or activities.

Interaction with other drugs

Inform your doctor about all the medications you take. Numerous medications can interact with voxelator. particularly:

  • Phenobarbital or any other barbiturate medication;
  • John's wort;
  • An antibiotic—rifabutin, rifampin, or rifapentine;
  • Cancer medicine—apalutamide, enzalutamide, and mitotane;
  • HIV or AIDS medicine—efavirenz, nevirapine;
  • Seizure medicine—carbamazepine, oxcarbazepine, phenytoin, primidone; or
  • Steroid medicine—dexamethasone, prednisone.

This isn't a complete list, and a variety of other medications could influence the voxelotor. This includes prescription and over-the-counter medications, vitamins, and herbal supplements. There are many possible interactions between drugs that are included here.



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