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Generic Name: Eravacycline (pronounced: [ER-a-vah-SYE”-kleen])

Brand name: Xerva
Form of dosage: intravenous powder for injection (100 mg or 50 mg).
Drug Class: Tetracyclines

What is Eravacycline?

Eravacycline, a tetracycline, is used in the treatment of serious stomach infections among adults.This medication guide does not list all possible uses of eravacycline.

Side effects of Eravacycline

If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives, difficulty breathing, swelling of your lips, face, tongue, or throat.

Eravacycline may cause serious side effects. If you experience:

  • Severe stomach pain bloody or watery diarrhea (may occur 2 months after the last dose of Eravacycline);
  • Dizziness, severe headaches, ringing ears, and vision problems
  • Nausea, vomiting, or severe abdominal pain spreading to the back.
  • Signs of a fungus infection include skin itching, white patches on your lips, vaginal discharge or itching, and problems with your nails or fingernails.

Eravacycline side effects may include:

  • Nausea, vomiting,
  • Pain, bruising, or swelling around the iv needle

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.


If you have an allergy to tetracycline, then you should avoid using eravacycline.Eravacycline use during pregnancy can affect the development of teeth and bones in an unborn child.Eravacycline cannot be used by anyone under 18 years of age. Eravacycline may cause permanent tooth yellowing or graying in children.

Before you take this drug

This medicine should not be used if you have an allergy to eravacycline.

Tell your doctor about any of the following:

  • Liver disease.

Eravacycline use during pregnancy can affect the development of the teeth and bones in the unborn child. Permanent tooth discoloration may occur later in life.Eravacycline may pass into breast milk and affect the development of teeth and bones in nursing infants. Do not breastfeed for at least four days after you have finished taking eravacycline.Eravacycline cannot be used by anyone under 18 years of age. Eravacycline may cause permanent tooth yellowing or graying in children.

How to take Eravacycline?

Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the label.Eravacycline can be infused into the vein. Your healthcare provider may give you your first dose and teach you how to use it properly.Please read and follow all instructions for use that come with your medication. If you do not understand the instructions, don't use eravacycline.If you have any questions, ask your pharmacist or doctor.The infusion of eravacycline can take up to an hour.Only prepare your injection when you're ready to administer it. If the medicine is cloudy, has changed color, or contains particles, do not use it. For new medicine, call your pharmacist.Even if you feel better quickly, continue to take eravacycline as prescribed. You can get infections resistant to medications if you skip doses. Eravacycline does not treat a virus such as the flu or the common cold.Do not freeze eravacycline powder.

If you store it at room temperature, the mixed eravacycline should be used within six hours. Do not freeze.This medicine comes in a single-use bottle (vial). After one use, throw it out, even if the medicine is still inside.

Details on dosage

Adult dose for intra abdominal infection:

Every 12 hours, give 1 mg/kg intravenously for 4–14 days.
Use: To treat complicated intraabdominal infections due to Escherichia coulis, Klebsiella cloacae (K. oxytoca), Enterococcus faecalis (E. faecalis), Streptococcus anginosus group, Staphylococcus aureus, Clostridium perfringens species, Bacteroides distasonis, and Bacteroides species.

What happens if I miss the dose?

If it is almost time for your next dose, skip any missed one and wait. Never take two doses of the same medicine at once.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

Avoid this

Antibiotics can cause diarrhea. This could be an indication of a new illness. Call your doctor if you have bloody or watery diarrhea before taking anti-diarrhea medication.You may get sunburned easier if you take eravacycline. Avoid tanning beds or sunlight. When you're outdoors, wear protective clothing and use sunblock (SPF 30 or higher).

Interaction with other drug

Inform your physician of any medications you are currently taking, including:

  • Enzalutamide;
  • Mitotane;
  • Rifampin;
  • St.
  • A blood thinner: warfarin coumadin jantoven
  • Seizure medicine—carbamazepine, phenytoin.

This list is incomplete. Eravacycline may be affected by other drugs, such as vitamins and herbs. This list does not include all possible drug interactions.