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Elbasvir and Grazoprevir

Generic name: elbasvir and grazoprevir [ELB-as-vir-and-graz-OH-pre-vir]

Brand name: Zepatier
Dosage format: oral tablet (50 mg–100 mg)
Drug class: antiviral combinations

What are Elbasvir and Grazoprevir?

Elbasvir as well as grazoprevir can be used to treat viral infections. medications that stop the hepatitis C virus (HCV) from growing in your body.Elbasvir and grazoprevir are elixir medicines that are used to treat the chronic infection of hepatitis C among adults. Grazoprevir and elbasvir are sometimes combined with a different drug known as ribavirin.Elbasvir and grazoprevir treat specific hepatitis C, but only for certain individuals. Only take the medication recommended for you. Don't share your medication with others.Elbasvir and grazoprevir are sometimes employed in patients who suffer from HIV. It is not a cure for HIV or AIDS.Elbasvir and grazoprevir could be used for other purposes that are not covered in this guideline.

Side effects of Elbasvir and Grazoprevir

See a doctor immediately. Get medical attention immediately if you notice symptoms or warning signs of an allergic response, such as difficulty breathing, hives, and swelling of your lips, face, and tongue.In rare instances, the combination of elbasvir and grazoprevir could cause severe liver damage. Tell your doctor immediately if you notice symptoms that include:

  • Lower stomach pain that is right-sided or swelling;
  • Vomiting, vomiting, and loss of appetite.
  • Feeling tired, confused, or lightheaded
  • Bleeding or bruising and vomiting blood.
  • Diarrhea, bloody, black, or black stool;
  • Dark urine, stools that are clay-colored
  • The skin is becoming yellow, or eyes.

If you take Ribavirin, consult your physician when you experience signs of a low red blood cell count (anemia).

  • Skin tone pale, cold hands and feet;
  • Unusual tiredness, feeling lightheaded
  • Breath shortness.

Common adverse effects of elbasvir or grazoprevir could include:

  • Headache;
  • Tiredness;
  • Anemia;

This isn't an exhaustive list of all the side effects. Other side effects could occur. Consult your physician for advice regarding medical adverse effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.

Similar or related drugs

Epclusa, Mayret, Harvoni, sofosbuvir/velpatasvir , Sovaldi, and Vosevi

Warnings

There is no need to take grazoprevir or elbasvir if you suffer from severe or moderate liver disease.Discuss with your doctor your current medications as well as any new medications you decide to start or stop taking. Numerous drugs interact, and some medications should not be combined.If you've had hepatitis B, taking the drugs elbasvir and grazoprevir may make this virus active or worse. Inform your doctor if you do not feel well and suffer from right-sided stomach vomiting, pain or loss of appetite, or a yellowing of your eyes or skin.

Before you take this drug

It is not recommended to use this medicine if you're allergic to either elbasvir or grazoprevir or if you suffer from

  • Moderate or severe liver disease, severe or moderate.

If you're taking elbasvir and grazoprevir in combination with ribavirin, to ensure that the medicines you are taking are suitable for you, talk to your physician about all of your medical conditions, as well as whether you are pregnant or nursing.

A variety of drugs interact and create dangerous side effects. Certain medications shouldn't be used with elbasvir or grazoprevir. Your doctor could alter the treatment plan when you are also taking:

  • Cyclosporine;
  • Rifampin;
  • John's wort;
    hiv or aids medications such as atazanavir, darunavir, efavirenz, lopinavir, saquinavir or tipranavir may help;
  • Seizure medicine—carbamazepine, phenytoin.

Inform your physician immediately if you have ever experienced:

  • Hepatitis B;
  • Problems with the liver beyond hepatitis C;
  • HIV (human immunodeficiency virus);
  • You may need a liver transplant or are awaiting the liver transplant you are waiting for.
  • If you are using an anticoagulant (Warfarin, Coumadin, or Jantoven) and you are undergoing regular "INR" or prothrombin time tests,

Elbasvir and grazoprevir are sometimes employed in conjunction with ribavirin. Both females and males who are taking ribavirin must use birth control to avoid pregnancies. Ribavirin can cause birth defects, miscarriage, or even death for unborn children when the father or mother are taking this medicine.Ribavirin is not a good choice when you are pregnant or if you're male and your sexual partner is expecting. Utilize effective contraception to stop the possibility of pregnancy. Continue using birth control for at most six months following the last dose of ribavirin.Contact your physician immediately. If you become pregnant during the time that one of the mothers or fathers is taking the drug ribavirin,It might not be safe to breastfeed while taking this medication. Consult your physician about any potential risks.Grazoprevir and Elbasvir are not drugs that are approved for use by those under 18 years of age. older.

How to take Elbasvir and Grazoprevir?

The doctor will conduct blood tests to ensure there are no conditions that could hinder you from using grazoprevir or elbasvir.Follow all instructions on the prescription label and also read the medication guides or instructions sheets. Make sure you use the medication exactly as prescribed.It is possible to take elbasvir and grazoprevir in combination or without food.The medicine should be taken every day.You'll need regular tests of your blood to determine the liver's function.If you've had any experience with hepatitis B, taking elbasvir and grazoprevir may cause the virus to be active or worse. It is possible that you will require frequent tests for liver function while taking elbasvir or grazoprevir and for a period of time after stopping.It isn't a good idea to stop using elbasvir or grazoprevir abruptly. Stopping suddenly could make Hepatitis C more difficult to treat with antiviral medication.Make sure to take all Hepatitis C medication as directed. Also, take note of all medication instructions you are given. Do not alter your dosage or schedule of dosing without a physician's approval. Anyone suffering from chronic hepatitis should stay under the supervision of a physician.Store at room temperature, away from heat and moisture. Store every tablet in the foil blister pack until you are able to use it.

What happens if I miss the dose?

You should take the medication as quickly as you are able, but avoid your missed dosage if it's nearing the time to take the next dose. Don't take two doses at a time.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact for help at the Poison Helpline at 1-800-222-1222.

What should be avoided?

The use of elbasvir and grazoprevir does not stop your illness from spreading. Don't engage in sexual activity that is not protected or share toothbrushes, razors, or razors. Consult your physician regarding safe methods to avoid HCV transmission during sexual contact. Sharing needles with medicine or drugs is not safe, even for a healthy individual.

Interaction with other drug

If you begin stopping or taking Elbasvir or Grazoprevir,  you may require adjustments to the dosages of other medications you are taking regularly.Many medications can affect elbasvir and grazoprevir. Some medicines should not be used in combination. Discuss with your doctor your current medications and any medication you begin or stop taking. This includes prescription and over-the-counter medicine, vitamins, and herbal supplements. The interactions between these products are not mentioned here.

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