What is Doptelet?
Doptelet can be used to treat thrombocytopenia in adults who have chronic liver disease and are scheduled to undergo medical procedures. Low platelet counts can increase the risk of excessive bleeding when undergoing certain medical procedures. Avatrombopag helps your body produce more platelets to prevent excessive bleeding. Doptelet can also be used to treat low platelet counts among adults with chronic immune thrombocytopenia when other treatments are not working. Doptelet can also be used to treat chronic immunothrombocytopenia if other treatments fail. Doptelet does not cure thrombocytopenia, nor will it restore platelet counts to normal for adults with chronic liver diseases or chronic immune thrombocytopenia.
Warnings
Please follow all instructions on the label or package of your medication. Inform your healthcare provider about your medical conditions and allergies. Also, tell them which medicines you are using.
Before you take this drug
Doptelet should not be used if you have an allergy to avatrombopag.
Tell your doctor of any of the following to ensure that this medication will be safe:
- A blood clot.
- A bleeding or blood-clotting disorder that is not thrombocytopenia
Before you begin taking this medication, your doctor will perform a blood test to measure your platelet count. This medicine is not known to harm a baby in utero. Inform your doctor if you are pregnant. Doptelet should not be used while breastfeeding or for 2 weeks following your last dose.
How to take Doptelet?
Doptelet should be taken exactly as prescribed. Read all the instructions and directions that come with your prescription. Sometimes, your doctor will change the dose. You must take the medication exactly as prescribed. Take this medication with food. Doptelet can be taken daily for chronic immunothrombocytopenia. Doptelet should be taken daily for five days, starting 10 to 13 days before the procedure. Follow your doctor's instructions regarding the timing and dosage of the medicine. To determine the length of treatment, your doctor will check your platelet counts every week. Blood tests may be required for several weeks following your last dose. Store away from moisture or heat at room temperature. Each tablet should be kept in its foil blister until you're ready to use it.
Details on dosage
Adult dose for thrombocytopenia:
Chronic liver disease:
- If your platelet count is less than 40 x 9/L, you should take 60 mg once daily, starting 10 to 14 days before the procedure.
- If your platelet count is less than or equal to 50 x 10 9/L, you should take 40 mg once daily, starting 10 to 13 days before the procedure.
Duration of treatment: 5 days
Comment: Patients should have their procedure performed 5 to 8 weeks after taking the last dose.
Use: To treat thrombocytopenia among patients with chronic liver diseases who are scheduled for a surgical procedure.
Chronic immune thrombocytopenia: oral 20 mg once daily. The dose or frequency should be adjusted to maintain a platelet count of 50 x 10 9/L or greater. Do not exceed the daily dose of 40 mg.
What happens if I miss the dose?
If you have chronic immune thrombocytopenia, take the missed dose as quickly as you can.Continue to take your daily dosage as prescribed and no more than one dose at a time.Before any scheduled medical procedure, call your doctor to get instructions.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention.
What should be avoided?
If your doctor prescribes any restrictions regarding food, beverage, or activity, follow their instructions.
Side effects of Doptelet
If you experience signs of an allergic reaction such as hives, difficulty breathing and swelling to lips, face, tongue or throat it's imperative that emergency medical assistance be sought immediately.
A blood clot could form while you are using Avatrombopag. If you experience:
- Shortness of breath, chest pain
- Fast heartbeats;
- Pain, swelling, or redness on one or both legs
- Stomach pain or tenderness
- Yellowing of the skin or eyes, or a sudden fever or chills;
- Bloody or tarry stool, vomiting blood, or vomit that looks like coffee grounds
Doptelet can cause a variety of side effects.
- Fever;
- Purple or red spots or bruising on the skin (nosebleeds or bleeding gums);
- Feeling tired
- Headache, joint pain;
- Cold symptoms include a runny nose or stuffy nose; sneezing; and a sore throat.
- Nausea, stomach pain;
- Swelling in the hands or feet is a common symptom.
There may be other side effects. Call your doctor if experiencing side effects. For medical advice regarding potential adverse reactions. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Interaction with other drug
Other drugs, such as vitamins and herbal remedies, may interact with Avatrombopag. Informing your physician of any medications you are currently taking and those you plan on discontinuing or starting will allow him or her to better assess any possible risks or interactions that arise from taking such drugs.
