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Denavir Cream

Generic name: penciclovir topical [pen-SYE-kloe-veer-TOP-ik-al]
The brand name is Denavir.
Class of drugs: topical antivirals

What is Denavir?

Denavir acts as an antiviral medicine. Denavir is a prescription-only cream that treats sores that

appear on the lips and result from the Herpes simplex virus. The medicine is intended for both children and adults who are 12 or older. Denavir isn't a treatment for cold sores. You might continue to suffer from cold sores in the near future. 


Avoid applying the cream to the inner part of the nose or inside or around the eyes.

Before taking this medicine

You shouldn't use the Denavir cream if you are sensitive to penciclovir. Because penciclovir topical (for the face) doesn't get absorbed by the body, taking this drug isn't expected to cause harm when you are pregnant or nursing. Denavir cream is not authorized to be used by anyone less than 12 years old.

How to take Denavir cream?

Utilize Denavir precisely as prescribed by your physician. Follow the directions on the prescription label. Do not take this medicine in smaller or larger amounts or for longer than prescribed.

Do not consume by mouth. Topical medicine should be used only on the face and lips. If this medication gets into your mouth or nose, wash it off by drinking water. Denavir is recommended for treating cold sores that are on your face and lips only. To get the best results, begin taking penciclovir as quickly as possible following the onset of signs of a cold-like sore (tingling or itching, redness, and a lump).

Cleanse your hands prior to and immediately after using Denavir cream. Also, wash and dry the area of your skin being treated. Spread a light layer of penciclovir on the sore. Make sure to cover just the cold sore, the skin area that you feel tingling, or signs of a cold sore that is developing. Apply the cream slowly until the medication disappears. Don't apply Denavir cream to an area inside your nose or near your eyes.

Denavir cream is typically applied every two hours during the day for four days in succession. Follow the instructions of your doctor for dosing extremely carefully. Contact your physician if your symptoms don't improve or if they become worse. Keep it at room temperature, free of heat and moisture.

Details on dosage

Usual Adult Dose for Herpes Simplex Labialis:

Apply the cream to the areas every two hours in the morning while you're awake.

The duration of therapy is 4 days.

Comments: Treatment should commence as soon as is feasible (i.e., in the predrome or when the lesions start to show).

Use: To treat herpes labialis recurrently (cold sores)

Usual Pediatric Dose for Herpes Simplex Labialis:

12-year-olds or older, apply cream to any affected area for 2 hours every day in the morning while you're awake.

The duration of therapy is 4 days.

Comment: Treatment should be initiated as soon as is feasible (i.e., at the time of prodrome or as soon as lesions begin to appear).

Use: In the treatment of herpes labialis recurrently (cold sores)

Do I be concerned if I miss a dose?

Do the missed dose when you remember. Don't miss any missed doses if it's close to the time for the next dose. Don't take extra medication to replace the missed dose.

What will happen if I take excessively?

A dose of Denavir cream isn't expected to cause harm. You should seek medical attention in an emergency or contact the poison help line at 1-800-222-1222 if you have accidentally swallowed the drug.

What should be avoided?

Don't apply Denavir to an area on the outside of your nose or close to your eyes. Rinse your eyes with water if this medication does end up in your eyes.

Side effects of Denavir


Take immediate medical attention. If you are experiencing

symptoms that indicate an allergic reaction, Denavir

symptoms include difficulty breathing, hives, and swelling of your lips, face, and tongue.

Consult your doctor immediately. If you experience extreme skin irritation, itching, or rash following the application of this medicine,

Common Denavir side effects can include:

  • Numbness or tingling wherever the medication was injected

  • headaches; or

  • Changes in your perception of your taste.

This isn't a complete list of all the side effects. Other side effects could be present. Contact your doctor for advice regarding medical effects. You can report symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

It's unlikely that other drugs you are taking by mouth or injecting can affect the topically applied penciclovir. Certain drugs may interact with each other. Be sure to inform your health professionals about all medications you are taking, which include prescription and non-prescription medicines such as vitamins and herbal remedies.