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Generic name:Danazol danazol [DAN-a-zol]
Name of the brand: Danocrine
Drug class: antigonadotropic agents

What is Danazol?

Danazolis a is synthesized steroid made from ethisterone. Danazol is used to treat endometriosis. Danazol can also be used to treat the symptoms caused by hereditary angioedema (an immune system disorder). Danazol decreases the production of bradykinin and can decrease the effect of a bradykinin-related storm. Bradykinin storms could be the cause of certain issues that COVID-19 patients experience.


Danazol is not a good choice for those who suffer from vaginal bleeding that is not diagnosed, porphyria, severe kidney or liver disease, or heart conditions that are serious, or if you've had a stroke, blood clot, or breast cancer. Don't use Danazol when you are expecting. Use effective birth control methods, and notify your doctor if you are pregnant.

Prior to use this drug

Danazol should not be used if you have an allergy to it or are suffering from

  • Undiagnosed vaginal bleeding
  • Serious heart issues;
  • A history of strokes or blood clots
  • Severe kidney or liver illness;
  • Porphyria (a genetic disorder of enzymes that can cause symptoms in the nervous system, skin, or nerves), also known as
  • A history of cancer related to hormones, which includes cancer of the breast, uterus, cervical, or vagina

To ensure that danazol is safe for you, ask your physician if you've previously had:

  • Heart issues;
  • High blood pressure;
  • Liver disease;
  • Kidney disease;
  • Epilepsy or any other seizure disorder
  • Diabetes or
  • Migraine

You might need to undergo an unfavorable pregnancy test prior to beginning this treatment. Don't use danazol in the case of pregnancy. It could harm the unborn baby or cause birth defects. Make sure you use a birth control method that is effective to avoid pregnancy while taking this medicine. Discuss with your doctor the possibility of using an alternative to hormonal birth control (such as condoms or diaphragms containing spermicide) to avoid the onset of pregnancy.

Danazol may be absorbed through breastmilk and cause harm to a nursing infant. It is not recommended to breastfeed when using Danazol. Danazol is not permitted for use by anyone who is younger than

How to take Danazol?

Follow the exact dosage of danazol as recommended by your physician. Follow all instructions on the label of your prescription and carefully read the medication guide or instructions sheets. The doctor might modify your dosage. You'll need to take regular medical tests. Danazol may affect the outcomes of certain medical tests. Inform any physician who treats you about the use of this drug. Danazol is a medication used by women to treat endometriosis. They must begin the treatment during their menstrual cycle.

Danazol is typically prescribed between 3 and 9 months in order to treat endometriosis. To avoid the onset caused by hereditary angioedema, it is possible to continue taking the medication for a longer period of time. Follow the doctor's instructions for dosing with care.

The dose you require may alter if you fall ill and/or have a fever infection, are undergoing surgery, or have a medical emergency. Discuss with your doctor any situation that may affect you. Do not alter the dosage or frequency of your medication without consulting your physician. Danazol should be stored at room temperature, free of heat, moisture, and light.

Details on dosage

Usual Adult Dose for Endometriosis:

Mild Disease:
Initial dose: 200 to 400 mg daily orally, given in two equal doses.
Maintenance dosage The gradual downward titrations must be done to ensure that amenorrhea is not deteriorating.
Therapy duration: up to 9 months

Moderate to Severe Disease or Patients Infertile Due to Endometriosis:
Initial dosage: 800 mg daily, orally administered in two doses divided
Maintenance dosage The gradual downward titrations must be done to ensure that amenorrhea is not deteriorating.
The duration of treatment: up to 9 months

The treatment should be initiated during menstrual cycles, or appropriate pregnancy tests are required prior to the beginning of treatment. This will ensure that the patient isn't pregnant during treatment.
The treatment should be continued for between 3 and 6 months, but it can last up to 9 months.
Treatment may be repeated in the event that symptoms return.

Use: Treatment for endometriosis that is a candidate for hormonal management.

Usual Adult Dose for Fibrocystic Breast Disease:

100-400 mg orally daily, administered in two divided doses


Most patients can be treated using simple measures (e.g., brassieres padded with padding and analgesics). Patients who require treatment with this medication may experience symptoms of extreme tenderness and pain.
Patients should be aware that treatment isn't completely safe; hormonal changes and recurrence of symptoms are common following discontinuation of treatment.
The drug is generally efficient in reducing symptoms of fibrocystic ductal breast disease (e.g., nodularity, tenderness, and pain). The tenderness and pain usually disappear within two to three months, and nodularity typically disappears after four to six months of continuous treatment.
A majority of patients will suffer from an occurrence of symptom recurrence within one year. Treatment can be restarted in this group if needed.

Treatment for symptomatic breast cancer fibrocystic by suppression of the ovarian function

Usual adult dose for angioedema:

Initial dosage: 200 mg orally 2-3 times per day.
After a positive initial response, the dose is best determined by reducing the dosage to 50% or lower in intervals of between 1 and three months (or longer).
If an attack does occur, the daily dose could be increased to 200 mg.

What happens if I miss the dose?

You should take the medication as quickly as you can. However, avoid any missed doses if it's nearing the time to take the next dose. Don't take two doses at a time.

Consult your physician for treatment in the event that you missed more than two doses in the same row.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact for help at the Poison Help Line at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any restrictions on your food, drink, or activities.

Side effects of Danazol

See a doctor immediately. If you are experiencing symptoms that you are experiencing an allergic reaction to Danazol, such as hivesface, or difficulty breathing and swelling of your lips, face and tongue,

Contact your doctor immediately. If you suffer from:

  • Inability to eat and stomach discomfort (upper right);
  • Cough that has bloody mucus or vomit that resembles coffee grounds
  • Jaundice (yellowing of the eyes or skin);
  • Bloody or tarry stools; dark urine
  • Weight gain or swelling;
  • A voice that is strained or hoarse; a sore throat;
  • The loss of hair or an increase in hair growth
  • Acne or other skin issues;
  • Unexplained muscle tenderness, pain, or weakness;
  • Increased pressure within the skull, - severe headaches, hearing ringing, dizziness, nausea, or vision problems, or pain behind your eyes or
  • Indications for a blood clot: sudden numbness, weakness, issues in speech or vision swelling, or redness in the leg or arm.

Danazol side effects that are common are:

  • Flushing (sudden redness, warmth, or tingling sensation);
  • Menstrual changes;
  • Abnormal vaginal bleeding or bleeding vaginally;
  • Breast changes;
  • Sexual issues;
  • Reduced amount of semen released during sex
  • Mood shifts, nervousness, or
  • Dryness of the vagina or irritation

This isn't a complete list of all the side effects. Others could happen. Consult your physician for advice regarding medical effects. You can report adverse reactions to the FDA at 1-800-FDA-1088

Interaction with other drugs

Inform your physician about any other medicines you are taking, including:

  • Carbamazepine;
  • Cyclosporine;
  • Tacrolimus;
  • Warfarin;
  • Insulin or oral diabetes medication or
  • Cholesterol-lowering medicines such as atorvastatin, lovastatin, or simvastatin.

This list is not comprehensive. Other medications can be incompatible with danazol, such as prescription and over-the-counter medicines, vitamins, and herbal products. Some interactions with drugs are not listed here. are listed here.