The Web Health


Dalfopristin and quinupristin

Generic Name: Dalfopristin and quinupristin [dal-FOE-pris-tin-and-kwi-NYOO-pris-tin].
The Brand Name: Synercid.
Dosage Format: Intravenous powder for injection (350 mg to 150 mg).
Drug Class: Streptogramins.

What are dalfopristin and quinupristin?

Dalfopristin and quinupristin are antibiotics that combat serious or life-threatening infections that are caused by bacteria. Dalfopristin and quinupristin are used to treat serious skin conditions or other organ systems. Dalfopristin and quinupristin can also be used for other purposes that are not mentioned in this guide.

Adverse negative effects dalfopristin and quinupristin

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, such as hives, difficulty breathing, and swelling of your lips, face, and tongue. Dalfopristin and quinupristin could cause serious adverse side effects. Consult your doctor immediately in the event that you experience:

  • Extreme stomach pains; diarrhea that is bloody or watery.
  • Swelling, pain, bruising, or extreme irritation of the IV needle.
  • Jaundice (yellowing of the eyes or skin).
  • A seizure (convulsions).
  • Irregular heart rate.
  • A sudden weakness or numbness sudden weakness or numbness; extreme headache rapid speech loss and difficulties with balance.

Common negative side effects of dalfopristin and quinupristin could be:

  • Slight irritation on the needle of an IV.
  • Kidney disease.
  • The liver condition.

This isn't an exhaustive list of possible side effects, and other side effects could be experienced. Consult your physician to seek medical advice on the effects. You can report any side effects to the FDA at 1-800-FDA-1088.


Follow all the instructions on your prescription label and on the label of your package. Be sure to inform your health professionals about your medical ailments and allergies, as well as the medicines you are taking.

Before you take this drug

It is not recommended to use quinupristin or dalfopristin if you are allergic to them.

To ensure that dalfopristin or quinupristin are safe for you, inform your doctor when you've had:

  • The occurrence of an allergy reaction to antibiotics.
  • The liver condition.
  • kidney disease.

It isn't known if the combination of dalfopristin and quinupristin can cause harm to a baby who is not yet born. Inform your doctor if you are expecting or planning to be pregnant. It isn't known if dalfopristin or quinupristin are absorbed into breast milk or whether they can affect nursing infants. Consult your physician if you are breastfeeding.

How to take dalfopristin and quinupristin?

Dalfopristin and quinupristin are injectable into a vein via an IV, often using an infusion pump, or via an IV centrally, or "PICC" line.

The medication is typically administered in a hospital. But you might be shown how to administer an IV at home. Do not inject yourself with this medication if you do not know how to apply the injection correctly and properly get rid of needles, IV tubing, and other equipment employed. Dalfopristin and quinupristin are to be administered slowly, and infusions can last for at least one hour. Contact your doctor immediately. If you're experiencing issues with your IV or if your medication isn't flowing freely from the bag into the tubing. The combination of quinupristin and dalfopristin is typically used for a minimum of seven days. Follow the directions on the prescription label. Don't use this medication in smaller or larger quantities or for longer periods than prescribed. Make sure to take this medication for the entire prescribed duration. The symptoms might improve before the infection has completely gone. In addition, skipping doses could increase your risk of developing new infections that are resistant to medications. Dalfopristin and quinupristin do not help treat the symptoms of a viral disease like the flu or the commonly occurring cold. If you store this medication at home, place the IV bag in a fridge and use it prior to its expiration date on the label of the medicine. Do not put it in the refrigerator.

Details on dosage

Usual Adult Dose for Skin or Soft Tissue Infection:

Complex: 7.5 mg/kg IV every 12 hours, infused over an hour

Usual Adult Dose for Bacteremia:

Vancomycin-resistant Enterococcus faecium infection: 7.5 mg/kg IV every 8 hours, administered for 1 hour
The indication for this condition is no longer recognized by the FDA. The data submitted did not verify the clinical benefits of this condition.

Usual Pediatric Dose for Skin or Soft Tissue Infection:

More than 12 years old No data is available.
from 12 to 18 years old: 7.5 mg/kg every 12 hours. infused over an hour

What happens if I miss a dose?

Contact your doctor for advice if you missed the dose of dalfopristin or quinupristin.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222. Overdoses can result in vomiting and breathing problems, as well as tremors and the loss of equilibrium and coordination.

What should be avoided?

Diarrhea can be caused by antibiotics, which could be an indication of a new infection. If you experience diarrhea that is bloody or watery, contact your doctor. Take no medication against diarrhea unless advised by your healthcare provider.

Interaction with other drugs

Numerous drugs are in a relationship with dalfopristin or quinupristin. The interactions with quinupristin are not all included in this article. Inform your doctor of your current medications and any that you decide to start or stop taking, particularly:

  • Methylprednisolone.
  • Carbamazepine.
  • Antiviral medicine for treating HIV/AIDS includes delavirdine, indinavir, nevirapine and ritonavir.
  • Cancer medicine—docetaxel, paclitaxel, vinblastine, vincristine.
  • Heart or blood pressure medication—diltiazem, nifedipine, verapamil.
  • Preventing organ transplant rejection medications (cyclosporine, tacrolimus).
  • A sedative—diazepam (Valium), midazolam.
  • "statin" cholesterol medications—atorvastatin, lovastatin, simvastatin, Zocor, Vytorin, Crestor, and others.

The list below isn't exhaustive, and a variety of other medications can interact with dalfopristin or quinupristin. This covers prescription and OTC medications, vitamins, and herbal products. Make a list of all your medications and give it to any doctor who cares for you.