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What is Caffeine and ergotamine (oral/rectal)?
Caffeine causes blood vessel narrowing (vasoconstriction). Ergotamine works by narrowing the blood vessels in and around the brain. A combination medicine containing caffeine and ergotamine can be used to prevent or treat a headache of this type. This medication is only for a headache that has already started. This medication will not reduce or prevent migraine attacks. It is not recommended to use caffeine or ergotamine to treat tension headaches, migraines, or headaches that are different than usual. This medication guide does not list all possible uses for caffeine and ergotamine.
Side effects of Caffeine and ergotamine (oral/rectal)
If you observe any of the following symptoms of an allergic reaction: hives, difficulty breathing or facial or throat swelling - seek medical assistance immediately!
Caffeine and ergotamine can cause serious side effects. Call your doctor immediately if:
- Experience severe abdominal or back discomfort? You could be experiencing significant distress.
- Bloody or tarry stool, vomiting blood, or vomit that looks like coffee grounds
- Leg pain, cramps, or swelling in the hips or legs;
- Blue-coloured toes or fingers, or numbness or tingling in the hands and feet;
- Muscle pain or weakness in your arms or legs
- Fast heart rate or slow heart rate
- A severe headache can cause blurred vision or pounding in the neck and ears.
- If you experience sudden weakness or numbness (especially on one side of your body), a severe headache, slurred words, or problems with balance or vision, then it is important to seek medical attention.
- You may experience painful sores in your rectum as a result of using rectal suppositories.
Overuse of caffeine and ergotamine can lead to serious side effects. Caffeine and ergotamine should not be used daily.
Side effects of caffeine and ergotamine include:
- Numbness, tingling, burning pain;
- Dizziness, spinning sensation;
- Weakness;
- Itching swelling
- Nausea, vomiting,
- Rectal ulcer or sore.
There may be other side effects. Call your physician if experiencing side effects. For medical advice regarding side effects. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Similar/related drugs
Botox, prednisone, diclofenac, celecoxib, sumatriptan, metoclopramide, and Indomethacin
Warnings
Certain medicines may cause dangerous side effects if they are combined with caffeine or ergotamine. This medicine should not be used if you suffer from coronary artery disease or hypertension. You may also have circulation problems, liver and kidney disease, or sepsis. Inform your doctor of all the medications you are taking, as well as any new ones. Some drugs are not to be taken together, and others can cause drug interactions. Do not use if you are pregnant or could become pregnant.
Before you take this drug
If you are allergic or have any of the following:
- Heart disease.
- High blood pressure
- Blood circulation problems
- Sepsis is a severe reaction caused by an infection.
- Liver disease
- Kidney disease
- If you think that you may be pregnant,
When caffeine and ergotamine are combined, many drugs can cause dangerous blood flow decreases. Side effects can be dangerous if there is a severe reduction in blood flow. Certain drugs shouldn't be taken with caffeine or ergotamine. If you use:
- Zileuton;
- An antidepressant—fluoxetine, fluvoxamine, nefazodone;
- An antibiotic—clarithromycin, erythromycin, metronidazole, telithromycin;
- Antifungal medicine: clotrimazole, fluconazole, itraconazole, ketoconazole,
- Antiviral medicines to treat HIV/AIDS: indinavir (nelfinavir), ritonavir (saquinavir), and nelfinavir (nelfinavir).
Avoid caffeine and ergotamine while pregnant. They can harm an unborn child or cause birth defects. While using this medication, use birth control to avoid pregnancy. Tell your doctor if you're pregnant.
This medicine should not be used while breastfeeding.
How to take Caffeine and ergotamine (oral/rectal)?
Do not exceed the recommended dose. Do not exceed the recommended dosage. The use of migraine headache medication in excess can worsen headaches. If the medication is not working as well to treat your migraine attacks, tell your doctor. This medication is not intended for daily use.
Use a caffeine and ergotamine tablet:
- As soon as you feel headache symptoms or if the attack is already underway, take 2 tablets of caffeine with ergotamine.
- You can take another tablet if your headache doesn't completely disappear after 30 minutes.
- You can take one tablet every 30 mins, up to 6 tablets in total for a migraine attack.
Call your doctor if you continue to experience migraine symptoms even after taking six tablets. Never take more than six tablets within a 24-hour period. Never take more than 10 tablets in a 7-day period.
You should not swallow a rectal suppository. This product is only to be used in the rectum.
Hands should be washed before and after using the suppository.
Use caffeine and ergotamine suppositories in the rectal area.
- Add 1 suppository to the migraine headache treatment regimen at the first signs of symptoms or when an attack is already underway.
- Remove the wrapping before inserting the suppository. Do not handle the suppository for too long, or it may melt.
- Lay on your back, with your knees pointing up towards your chest. Insert the suppository gently into your rectum, pointed tip facing you.
- Stay in bed for a couple of minutes to let the suppository dissolve. You should experience little to no discomfort. You should avoid using the toilet for at least one hour.
- Use 1 more suppository if your headache has not gone away completely after 1 hour.
Call your doctor if you continue to experience migraine symptoms even after using two rectal suppositories. Use no more than two suppositories for each headache. No more than five suppositories in a 7-day period This medication should not be shared with anyone else, even if the other person has similar symptoms. Store tablets away from moisture, light, and heat at room temperature. Do not freeze rectal supppositories.
Details on dosage
Adult dose for migraine:
Oral: Ergotamine 1 mg; caffeine 100 mg per tablet.
Initial dose: Take 2 tablets orally when you first notice an attack. Add 1 tablet every 30 minutes as necessary, but do not exceed the maximum dose.
Maximum dose: Six tablets for any one attack and 10 per seven-day period.Rectal: Ergotamine 2 mg; caffeine 100 mg per suppository:
Initial dose: 1 tablet rectally when the first signs of migraine appear; an additional tablet may be given after one hour, if necessary.
Maximum dose: two suppositories for each attack; 5 per week-long period.Comments:
Early administration provides maximum efficiency.
This drug should not have a daily, chronic administration.
Use: To prevent or abort vascular headaches such as migraines, migraine variants, or "histaminic cerephalalgia".
What happens if I miss the dose?
You are unlikely to miss a dosage since caffeine and ergotamine are only used when necessary. Take no more than six caffeine and ergotamine tablets per day, or 10 tablets in a week. Use no more than 5 suppositories a week or 2 suppositories for each headache.
What happens if I overdose?
If you feel you've used too much caffeine or ergotamine, seek emergency medical attention. A caffeine and ergotamine overdose can be deadly. Overdose symptoms include blurred vision, headaches, lightheadedness or feeling drowsy, seizures, and signs of reduced blood flow (pain, numbness or tingling in the arms or legs, weak pulses, or a blue appearance).
What should be avoided?
Avoid using caffeine and ergotamine for migraine headaches within 24 hours of taking another migraine headache medication, such as:
- Dihydroergotamine, ergonovine, or methylergonovine;
- Almotriptan is also known as eletriptan or frovatriptan.
Grapefruit and juice can interact with caffeine or ergotamine, causing unwanted side effects. Use grapefruit products sparingly if you are taking caffeine or ergotamine.
Interaction with other drug
Inform your physician of all medications you are currently taking.Caffeine and ergotamine are affected by many drugs, including:
- Nicotine gum or skin patch;
- Antibiotics or antifungal medicines;
- Diet pill, stimulants, or medication to treat Attention Deficit Hyperactivity Disorder (ADHD);
- Heart or blood pressure medication;
- Medicines to treat allergies, colds, and asthma
This list is incomplete, and other drugs can also affect caffeine and ergotamine. These include prescription and over-the-counter medicines, vitamins, and herbal products. This list does not encompass all possible interactions.