The Web Health



Generic Name: Belumosudil BEL-ue MOE-soo dil [BEL-ue-MOE-soo-dil].
Brand Name: Rezurock.
Dosage Format: Oral tablet (200 mg).
Drug Class: Selective immunosuppressants

What is belumosudil?

Belumosudil is a treatment for chronic host-graft disease after at least two other therapies failed to treat it. not work. Belumosudil is intended for children and adults who are at least 12 years old. Belumosudil can also be used for reasons not mentioned in this guideline for medication.

Side effects of Belumosudil

See a doctor immediately. Get medical attention immediately if you notice warning signs of an allergic response, such as symptoms of hives, difficulty breathing, or swelling of your lips, face, or tongue.

Belumosudil may cause serious side effects. Consult your doctor immediately. If you suffer from:

  • Severe ongoing nausea, vomiting, or diarrhea.
  • Issues with the liver: loss of appetite, nausea, gastric symptoms such as stomach pain (upper right side) and dark urine, jaundice (yellowing of the eyes or skin).
  • Symptoms and signs of infection symptoms of infection: fever, colds The symptoms of infection include chills, fever, body aches, uncharacteristic fatigue, bleeding or bruising, or painful urination. the cough with mucus, chest pains, or feeling short of breath.

Common negative side effects of belumosudil include:

  • Stomach pain, nausea, and diarrhea.
  • Infections, bleeding.
  • High blood pressure.
  • The cough and the shortness of breath.
  • Bone or muscle pain.
  • Swelling.
  • Headache.
  • Feeling tired or weak.

This list does not constitute an exhaustive compilation of side effects associated with therapy. Other things could happen. Contact your physician to seek medical advice on adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


Take only according to the directions. Inform your doctor if you are taking other medications or have any other medical conditions or allergies.

Before you take this drug

Inform your doctor if you have ever suffered from kidney or liver problems. You might need to undergo a pregnancy test that is negative prior to commencing this treatment. Women and men who are taking belumosudil must use effective birth control in order to avoid pregnancy. Belumosudil can harm an unborn baby if the father or mother are using the drug.

Use the birth control for at least one week following the last dose. Inform your doctor immediately when you become pregnant. It is possible for pregnancy to be at lower risk when either the father or mother is taking this medication. Women and men alike are advised to use birth control to stop pregnancy since the medication can cause harm to a baby who is not yet born. Avoid breastfeeding during the course of this medication and for at least one week following your last dose.

How to take belumosudil?

Follow the instructions on the prescription label and review all medication guides and instructions. Make sure you use the medicine exactly as prescribed.

Belumosudil should be taken at least every day, along with an entrée. Be sure to follow your doctor's dosage instructions with care. Take a glass of water on a daily routine..

Take the tablet in one swallow and don't crush, chew, or break it. You'll need regular blood tests to determine the liver's function. Keep tightly sealed to keep at room temperature, far from heat and humidity. Place the tablets in their original containers together with the pack or canister of preservative that absorbs moisture.

Details on dosage

Typical Pediatric Dose for Graft Versus Host Disease:

200 mg orally, once a day, up to the time of progression to persistent GVHD that calls for new treatment in the system.
Use: To treat adults suffering from chronic graft versus host disease (chronic GVHD) after the failure of at least two previous lines of systemic therapy.

The Standard Pediatric Dose for Graft Versus Host Disease:

200 mg orally, once a day, for a period of time until the onset of chronic GVHD that calls for a new systemic treatment
Use: To treat children aged 12 and over with chronic graft-versus-host disease (chronic GVHD) after failure of at least two previous treatments with systemic therapy.

What happens if I miss a dose?

You can take the dose you missed the same day that you remembered it. The next dose should be taken at the normal time and adhere to your daily schedule. Don't take more than one dose in a single day.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any limitations on foods, drinks, or activities.

Interaction with other drugs

Inform your doctor about any current medications you are taking. There are many drugs that can affect belumosudil, particularly:

  • Phenobarbital or another barbiturate drug.
  • John's wort.
  • An antibiotic—rifabutin, rifampin, or rifapentine.
  • Cancer medicine—apalutamide, enzalutamide, and mitotane.
  • HIV or AIDS medicine—efavirenz, nevirapine.
  • A proton pump inhibitor stomach acid medicine—esomeprazole, lansoprazole, omeprazole, Nexium, Prevacid, Prilosec, Protonix, and others.
  • Seizure medicine—carbamazepine, oxcarbazepine, phenytoin, primidone.
  • Steroid medicine—dexamethasone, prednisone.

This list isn't complete, and other medications may influence belumosudil. This covers prescription and OTC medications, vitamins, and herbal products. The interactions of all drugs are listed here.