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Generic name: botulism immune globulin [BOT-ue-lizm-im-MYOON-GLOB-yoo-lin]
Drug class: immune globulins

What is BabyBIG?

It is made of human plasma. It contains antibodies that help protect your body against infection due to botulism toxins type A and B.BabyBIG treats infant botulism that is caused by toxin types A or B. It is prescribed for children younger than one year.This medication guide does not list all possible uses of BabyBIG.

Side effects of BabyBIG

During the treatment, your baby will be under constant supervision.If your baby shows any of the following signs of an allergy: hives, difficulty breathing, swelling of your lips, face, or throat, and/or difficulty swallowing, seek emergency medical attention.

If your baby is suffering from:

  • Tenderness, redness, or warmth in the arms and legs, or a blue or purple appearance;
  • Blue lips, pale skin, difficulty breathing, and fussiness are all symptoms of a lack of oxygen.
  • Fewer wet diapers, less urination than usual
  • Yellowed skin, dark-colored urine;
  • Low sodium levels in the body can cause confusion, weakness, nausea, and loss of motor skills.
  • Swelling around the spinal cord or brain; fever; neck stiffness; sensitivity to lights; weakness; sleepiness; and vomiting

Some of the common side effects associated with babybig include:

  • Mild skin rash on the face, chest, stomach, or back of the baby;
  • Chills and body aches
  • Wheezing

There may be other side effects.Need medical advice regarding side effects? Visit your physician. The FDA can be contacted at 1-800-FDA-1088 to report side effects.


BabyBIG should not be given to your baby if they have an immune globulin A deficiency (IgA) or if they are anti-IgA.After receiving BabyBIG, your baby should not be vaccinated with a "live vaccine" (mumps, rubella poliovirus, yellow fever varicella, rotavirus) for at least three months.

Before you take this drug

BabyBIG should not be given to your baby if they have ever experienced an allergic reaction to immune globulins or if they are immune globulin A deficient with antibodies to IgA.

Tell your doctor if your baby has had any of the following:

  • Kidney disease
  • Diabetes;
  • A vaccine;
  • Dehydration
  • Treatment with medicines that weaken your immune system

BabyBIG may be made with viruses or other infectious agents. Plasma is treated and tested to reduce the chance of contamination. However, there is a very small risk that it may transmit a disease. You should ask your doctor if there are any risks.

How to take BabyBIG work?

Follow all instructions given by the caregivers for your child to ensure that you are able to provide your baby with the best care possible.BabyBIG is administered as an intravenous infusion. This infusion will be given to your baby in a hospital or clinic setting.BabyBIG treatment is typically given only once.During the infusion, your baby's blood pressure, oxygen level, breathing, and other vital indicators will be closely monitored.Your baby may require blood tests to ensure that BabyBIG has not caused any harmful effects.

What happens if I miss the dose?

BabyBIG does not require a daily dosage schedule because it is only used in a single dose.

What happens if I overdose?

BabyBIG will only be administered by healthcare professionals in a medical environment. An overdose is therefore unlikely.

What should be avoided?

You should not give your baby a live vaccine for 3 months following the BabyBIG vaccination. These include measles (MMR), rubella, mumps (MMR), yellow fever (YF), or varicella (chickenpox). The vaccine might not be as effective during this period, and your baby may not be fully protected from disease.

Interaction with other drug

Other drugs, such as vitamins and herbal products, may also affect BabyBIG. Inform your doctor of all the medicines you are taking and those that you stop or start using.