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Xenleta (oral/injection)

Generic name: lefamulin (oral or injection) [ le-FAM-ue-lin ]
The brand name is Xenleta.
Classification of drugs: miscellaneous antibiotics

What is Xenleta?

Xenleta is a treatment for certain kinds of pneumonia in adults.

Xenleta could also be used to treat conditions that are not covered in this guide.

Side effects of Xenleta

See a doctor immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as hives, difficulty breathing, or swelling of your lips, tongue, throat, or face.

Xenleta could cause serious adverse side effects. Contact your doctor immediately if you suffer from:

  • Intense stomach pains, diarrhea that is bloody or watery (even when it happens months after the last dose),
  • Low potassium level: leg muscle cramps constipation, irregular heartbeats, fluttering of your chest, thirst, or increased need to urinate tingling or numbness, muscular weakness, or a feeling of limpness

Common negative effects of Xenleta include:

  • Nausea, vomiting, diarrhea;
  • Sleep problems (insomnia);
  • Low potassium
  • Headache;
  • Abnormal liver function test results abnormal liver function tests
  • Swelling, pain, bruises, or irritation in the area where the medicine was injected.

This is not a comprehensive list of possible side effects, and others could happen. Contact your doctor for advice regarding medical effects.If you have any concerns, report the reaction to FDA by calling 1-800-FDA-1088.

Warnings

Discuss with your doctor the medicines you are currently taking as well as any new medications you decide to start or stop taking. A variety of drugs interact, and certain drugs shouldn't be taken together.

Before you take this drug

It is not recommended to take Xenleta if you have an allergy to it.

A variety of drugs interact and result in dangerous consequences. Certain medications should not be taken with Xenleta. Your doctor could alter your treatment plan if you also take other medications to treat asthma, infections, heart conditions, high blood pressure, mental illness, depression, malaria, cancer, or HIV.

Inform your doctor if you were ever diagnosed with:

  • Heart rhythm disorders (especially when you are taking medications in order to manage them);
  • Long QT syndrome;
  • Liver disease
  • Kidney disease (or those who are taking dialysis).

It is possible that you will need to take an unfavorable pregnancy test prior to beginning this treatment.

Xenleta could cause harm to a baby who is not yet born. Use effective birth control to stop pregnancy while using Xenleta and for a minimum of two days following your last dose. Consult your physician when you begin to become pregnant.

You shouldn't give birth within two days of using Xenleta. If you are using a breast pump during this period, throw away the milk you've collected. Don't give it to your infant.

How to take Xenleta?

Follow the directions on the label of your prescription and read the medication guide or instructions sheets. Follow the medication exactly as prescribed.

Oral Xenleta is taken through the mouth.

Take Xenleta orally in the absence of a stomach at least one hour prior to or two hours after the meal.Use the Xenleta oral with an entire glass (6 to 8 ounces) of water. Suck the tablet completely and make sure you don't crush, chew, or tear it.

Xenleta injections are administered as injections into veins. Your healthcare professional will administer the first dose and instruct you on how to make use of the medicine on your own.

Be sure to read and adhere to any instructions for use that come with your medication. Consult your physician or pharmacist to clarify any instructions.Xenleta injections must be mixed with the aid of a liquid (diluent) prior to use. If you decide to inject yourself, make sure you understand how to prepare and maintain the drug.

Only inject once you're ready to administer it. Don't use any medicine that changes color or has particles. Contact your pharmacist to inquire about a new medication.Xenleta injections should be administered slowly. The injection can take up to 60 minutes to finish.You'll require frequent blood tests to monitor your liver's functioning.

Make sure to take this medication for the prescribed amount of time, even if symptoms improve quickly. Inadequate doses could increase your chances of getting an infection that is intolerant to medications. Xenleta does not treat viral diseases like influenza or a typical cold.Keep the tablet in the room at room temperature, far from heat and moisture.Keep the Xenleta injection in the refrigerator. Do not freeze. The bags containing the diluent should be kept at room temperature.Every bottle is intended for only one use. It is discarded after one use, regardless of whether there is any remaining medicine inside.After mixing the Xenleta injection with the diluent, you can store the mix for 24 hours at room temperature or for up to 48 hours in the refrigerator.

What happens if I miss a dose?

Utilize the medication as soon as you can; however, take a break from any missed doses if the coming dose falls to be taken in just less than eight hours. Don't use two doses in one go.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line at 1-800-222-1222.

What should be avoided Xenleta?

Antibiotic medicines can trigger diarrhea, which can be an indication of an infection that has just begun. If you are experiencing diarrhea that is bloody or watery, consult your physician prior to applying anti-diarrhea medicines.Don't take care not to share Xenleta with anyone else, even if they suffer from similar symptoms.

Interaction with other drugs

There are times when it's not safe to take certain medications together. Certain medications can alter the blood levels of other medications that you take, which can create side effects or render the medication less effective.

Xenleta may cause serious heart issues. Your risk may be increased if you utilize other medications to treat asthma, infections, heart conditions, high blood pressure, depression, mental illness, cancer, malaria, or HIV.Numerous drugs can impact Xenleta. This includes prescription as well as over-the-counter medications, vitamins, and herbal remedies. Not all interactions are mentioned here. Discuss with your physician all the medications you currently take and any medications you begin or stop taking.

 

DRUG STATUS

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Prescription only

Pregnancy & Lactation

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