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Generic name: calaspargase pegol [kal-AS-par-jase-PEG-ol]
The class of drug: miscellaneous antineoplastics

What are Asparlas?

Asparlas helps treat chronic lymphoblastic leukemia in infants and young adults aged 1 month to 21 years old.Asparlas are also used for reasons not mentioned in this guideline.

Side effects of Asparlas

Seek medical attention immediately. If you notice symptoms that indicate an allergic reaction, such as itching, hives itching, a sensation of lightheadedness, wheezing or breathing difficulties, or swelling of your lips, face, and tongue,You will be closely monitored for a minimum of 1 hour following each injection to ensure there aren't any allergic reactions.

Asparlas may cause serious side effects. Contact your physician immediately in the following cases:

  • Simple bleeding, unusual bruises;
  • High blood sugar—increased thirst, more frequent urine production, dry mouth, the odor of fruity breath;
  • Pancreatitis—severe discomfort in your upper stomach, which spreads into your lower back, as well as nausea;
  • Problems with the liver: loss of appetite and abdominal discomfort (upper right side) dark urine, jaundice (yellowing of the eyes or skin),
  • Indications of a blood clot: headache and sudden numbness, blurred vision or chest pain, redness, or swelling in the ankle or leg.

The cancer treatment may be delayed or discontinued permanently when you experience certain adverse effects.

Common asparlas side effects may include:

  • Pancreatitis;
  • Problems with blood clotting;
  • Abnormal tests of liver function.

This list does not comprise all potential side effects. Other effects may also be present. Consult your physician to seek medical advice on the effects. Please call 1-800-FDA-1088 if any adverse reactions arise and report them promptly to FDA.


You shouldn't make use of Asparlas if you've ever had Pegaspargase and it triggered the allergic reaction of bleeding clots in the blood, pancreatitis or bleeding, or liver issues.

Before you take this drug

It is not recommended to make use of Asparlas in case you are allergic to it or:

  • If you suffer from a liver condition,
  • You have experienced a severe allergy to the pegaspargase
  • You have experienced an apex blockage, pancreatitis, or a serious bleeding issue caused by taking asparaginase.

Speak to your doctor if you were ever diagnosed with:

  • Pancreatitis;
  • Heart-related problems;
  • A blood clot;
  • Liver disease.

Asparlas can affect a newborn baby. Use effective birth control to stop pregnancy while taking this medication as well for a minimum of 3 months following the last dose.Asparlas can have a potential interaction when used in combination with contraceptives for birth. To avoid pregnancy while taking this medication, you should use an effective, non-oral method for birth control (injection implant, infusion patches, skin patches, vaginal ring) as well as a barrier form that provides birth control (condom diaphragm, diaphragm cervical cap, and contraceptive sponge).Avoid breastfeeding while taking this medication, and at least 3 months following the last dose.

How to take Asparlas?

Asparlas is administered as an infusion into the vein. The healthcare professional will give the injection.Asparlas is typically given at least once every 21 days. Your physician will decide the length of time you will be treated by Asparlas.Asparlas doses are determined by the surface area of your body (height as well as weight). The dose you require could change as you lose or gain weight, or if you're still expanding.You'll require regular medical tests.

What happens if I miss the dose?

Consult your physician for further instructions in the event that you don't make an appointment to see your Asparlas.

What happens if I overdose?

For medical emergencies, seek emergency medical help or contact the Poison Help Line at 1-800-222-1222 for help.

What should be avoided?

Follow the instructions of your physician regarding any restrictions on your food, drink, or activities.

Interaction with other drug

Other medications that can affect Asparlas include prescription and non-prescription medicines, vitamins, and herbal products. Inform your physician about the medicines you are currently taking and any medication you begin or stop taking.