Aptivus

What is Aptivus?

Aptivus is an anti-viral medication that prevents the human immunodeficiency virus (HIV) from multiplying within your body.Aptivus is used in conjunction with another medication called Ritonavir for the treatment of HIV, which is the virus that causes acquired immunodeficiency disorder (AIDS).Aptivus isn't a treatment for HIV and AIDS.

Warnings

You shouldn't take Aptivus if you suffer from severe or moderate liver disease.Discuss with your doctor all the medications you are currently taking as well as any new medications you decide to start or stop taking. Numerous drugs can interact, and certain medications should not be combined.Certain patients taking Aptivus and ritonavir have experienced serious medical issues, including bleeding from the liver and damage to the brain. Stop taking these medications and seek emergency medical attention if you experience the following symptoms: upper stomach pain that is right-sided, nausea, hunger loss dark urine, stools that are clay-coloured, jaundice Ocular yellowing or skin yellowing), and abnormal bleeding. abruptly extreme headache or issues with vision or speech.

Before you take this drug

You shouldn't take Aptivus in the event that you are allergic to tipranavir or suffer from:

• moderate to severe liver disease ranging from moderate to severe.

Certain medications can trigger unwanted or hazardous effects when taken in conjunction with Aptivus. Your doctor might alter the treatment plan when you are also using:

• Alfuzosin;
• Cisapride;
• Lurasidone;
• Pimozide;
• Rifampin;
• Sildenafil (revatio for pulmonary arterial hypertension);
• John's wort;
• Ergot medicine: dihydroergotamine, ergotamine, ergonovine, and methylergonovine;
• Heart medication: amiodarone, flecainide, propafenone, quinidine;
• A sedative—oral midazolam, triazolam;
• "statin" cholesterol medicine atorvastatin, lovastatin, and simvastatin.

Speak to your doctor if you have ever suffered from:

• Liver disease (especially hepatitis b or c);
• Diabetes;
• A hemorrhagic disorder like haemophilia
• An allergy to sulfa-containing drugs

Speak to your physician if you are expecting a baby, and take your medication correctly to prevent an infection. HIV could be transmitted to your child if the virus is not managed during pregnancy. Your name could be included on a registry that tracks the effects of antiviral medication on infants.Aptivus can make contraceptives less efficient. Discuss with your doctor the possibility of using non-hormonal birth control (condom diaphragm or diaphragm with menstrual spermicide) to stop pregnancy.Women suffering from HIV or AIDS shouldn't breastfeed their babies. Even if the baby is born with no HIV or AIDS, the virus could be passed on to the child by the milk you give it.Aptivus should never be given to children younger than 2 years.

Similar or related drugs

Biktarvy, Descovy, Truvada, Tenofovir, Atripla, Complera, and Stribild

How to take Aptivus?

Follow your physician's exact dosage instructions. Follow the directions on the prescription label and go through all medication guides and instructions sheets. Follow the medication exactly as prescribed.Aptivus can be taken with the drug ritonavir (Norvir). Make use of tipranavir and ritonavir frequently for the best results.You should take your medicine along with food if you are taking tipranavir with the tablets of ritonavir.It is possible to take the medicine either with or without food if you are taking the tipranavir capsules with ritonavir or liquid.Suck the capsules up whole. Don't chew or open the capsule.Make sure to measure Aptivus's liquid with care. Utilise the dosing syringe that comes with a dosage measuring device (not the kitchen spoon).Inform your doctor if your child taking this medication has any changes in weight or height. Tipranavir dosages are determined by the body's area (height as well as weight) in children. Any changes in your body could alter the dosage.You'll need to take regular medical tests.If you require surgery, inform your surgeon beforehand that you're taking this medication.Utilise all HIV medications according to the directions, and carefully read the drug guides you are given. Do not alter your dosage or dosing schedule unless you have the advice of your physician. Anyone suffering from HIV must remain under the supervision of a physician.Keep an open container filled with Aptivus capsules in the refrigerator. Don't freeze. When you open the bottle, you can store the capsules at room temperature.Keep Aptivus liquid at room temperature, away from heat and moisture. Do not keep the liquid in a refrigerator.Dispose of any capsules or liquids that you do not use within 60 days from the first time you opened the medicine bottle.

Details on dosage

Usual Adult Dose for HIV Infection:

Tipravir 500 mg and ritonavir 200 mg are taken orally once every day.
Use: When combined with ritonavir or other antiretrovirals, to aid in treating HIV-1 infections in patients who have had therapy experience and are infected with HIV-1 strains that are more resistant than 1 protease inhibitor.

Usual Paediatric Dose for HIV Infection:

Between 2 and 18 years old:
Based upon weight, tipranavir is 14 mg/kg and ritonavir is 6 mg taken orally every day, twice.
Based on BSA: tipranavir 375 mg/m2 plus ritonavir 150 mg/m2 oral every day, twice
Maximum dose: tipranavir 500 mg/dose plus ritonavir 200 mg/dose
Comments:
Special attention is required for dose calculation as well as transcription of medication orders, information on dispensing, and dosing directions to decrease the risk of medication errors or overdose.
The dose for children should not be greater than the dose for adults.
Use: In conjunction with ritonavir and other antiretrovirals for treating HIV-1 infections in patients who have had therapy experience and are infected with HIV-1 strains that are resistant to more than one protease inhibitor.

What happens if I miss the dose?

Do not take the medicine for as long as you can. However, avoid your missed dosage if it's nearing the time to take the next dose. Don't take two doses at a time.Make sure you refill your prescription before you are out of medication completely.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

If you are also taking doanosine, you should do it two hours prior to or after taking Aptivus.Do not take vitamin E supplements if taking the liquid version of Aptivus.The use of this medication will not hinder the spread of your disease. Don't engage in sexual activity that is not protected or share toothbrushes or razors. Discuss with your physician safe methods to avoid HIV transmission through sex. Sharing needles with medicine or drugs is never a good idea, even for a healthy individual.

Side effects of Aptivus

See a doctor immediately. If you are experiencing symptoms of an allergy reaction with Aptivus: hives, breathing difficulties, or swelling of your lips, face, or tongue,Some patients taking Aptivus with ritonavir may have serious medical issues, including bleeding and liver damage to the brain.
Stop taking this medicine and seek medical attention if you suffer from:

• Upper stomach pain, right side nausea, vomiting, or loss of appetite. Black stools, dark urine, and jaundice (yellowing of the eyes or skin)
• Abnormal bleeding, sudden and severe headache, or issues in vision or speech.

Contact your doctor immediately. If you suffer from:

• Extreme skin severe rash blisters and peeling, redness or sunburn
• The skin and muscular or joint pains, swelling, or a tightness in your throat.
• Increased thirst, more frequent consumption of food, thirst, dry mouth

Aptivus may affect the immune system and cause adverse reactions (even weeks or even months after taking the medication). Consult your physician if you suffer from:

• Indications of an infection that is new, like night sweats, fever, swelling of the glands, cold sores, cough, wheezing, diarrhoea, and weight loss;
• Difficulty swallowing or speaking difficulties with balance, weak eye movement, or prickly sensation problems swallowing or speaking;
• Swelling in your throat or neck (enlarged thyroid), menstrual cycles, impotence

Common side effects associated with aptivus include:

• Nausea, vomiting, diarrhea, and  stomach pain;
• The skin rash (especially when it is in the case of children);
• Headache, fever, fatigue feeling,
• Modifications in the appearance or shape of your body fat (especially on your arms and legs, face, neck, breasts, and waist).

This is not a comprehensive list of all side effects. Other effects may also be present. Consult your physician to seek medical advice on the effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Interaction with other drug

Certain drugs can be incompatible with tipranavir and certain drugs shouldn't be taken at simultaneously. Inform your doctor about all the medications you are currently taking as well as any medication you are about to start or stop taking. This includes over-the-counter and prescription medicine, vitamins, and herbal supplements. There are not all interactions included in this list.