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Generic name: coagulation factor Xa [koe-AG-ue-LAY-tion-FAK-tor-Xa]
Classification of drugs: anticoagulant reversal agents

What is Andexxa?

Andexxa is a protein that can reverse the effects of anticoagulant drugs that are prescribed to prevent or treat blood clots. Reversing anticoagulant medications is required when you experience dangerous bleeding that isn't controlled or under control because of the way this medicine operates.Andexxa is used to manage bleeding that is not controlled when people take one of the anticoagulants, rivaroxaban (Xarelto) or apixaban (Eliquis).Andexxa has been approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical trials, healthy volunteers showed positive responses to Andexxa; however, further research is required.Andexxa could also be used to treat conditions not covered in this medication guide.

Side effects of Andexxa

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, like hives, trouble breathing, or swelling of your lips, face, or tongue.

Andexxa may cause serious side effects. Contact your physician immediately. If you suffer from:

Burning or pain after you urinate;Cough with chest pain, mucus, and the feeling of having a short breath;Fever, chills, Continued bleeding after treatmentThe effects of anticoagulant medications can increase the risk of blood clot stroke, stroke, or even death. Contact a medical professional immediately when you experience any of these symptoms following having been treated by Andexxa, particularly in the event that you haven't been taking anticoagulant medication for a while.Symptoms of a blood clot: sudden weakness or numbness; problems with speech or vision; swelling or redness of the leg or arm; Symptoms of a heart attack: chest pressure or pain, pain that spreads into your shoulder or jaw, nausea, sweating

Common adverse consequences associated with the coagulation factor xa could include:

Lung problems;Uncomfortable urination;Inflammation, pain, swelling, or irritation around or around the needle.This list doesn't represent an exhaustive compilation of side effects. Other side effects could occur. Consult your physician to seek medical advice on the effects. Call 1-800-FDA-1088 if you experience an adverse reaction and they can assist in reporting it to the FDA.


Andexxa is used to counter the effects of anticoagulants that can increase your chance of developing a blood blockage, heart attack, stroke, or even death. Look out for signs like chest pain, sudden weakness or numbness, problems with vision or speech, and swelling or redness on a leg or arm.

Before you take this drug

It is not recommended to treat Andexxa. If you've had any allergic reactions the clotting factor medication.In the event of an emergency, there is a chance that you will not be able to inform your carers about any health issues. It is important that the doctor who cares for you afterwards knows the medicine you took.In the event of a crisis, there is a chance that you will not be able to inform carers whether you're breastfeeding or pregnant. It is important that the doctor who is caring for your baby or your pregnant mother knows that you've received this medication.

How to take Andexxa?

Andexxa is administered as an injection into the vein. The healthcare professional will give the injection.Andexxa should be administered slowly. The infusion could take up to 2 hours to be completed.After your bleeding is under control, you may have to start taking anticoagulants in order to prevent the formation of blood clots. Follow the directions of your doctor attentively.

What happens if I miss the dose?

Since you'll be receiving Andexxa in a clinical setting, it is unlikely you will miss a dose.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact for help at the Poison Help Line at 1-800-222-1222.

What should be avoided?

Follow the doctor's advice regarding any restrictions on your food, drink, or activities.

Interaction with other drugs

Other medications can impact Andexxa, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Discuss with your doctor all the medications you currently use and any medication you begin or stop taking.