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Anagrelide

Generical name: anagrelide [an-AH-gre-lide] An-AH-gree-lide
The brand name: is Agrylin.
Dosage form: oral capsule (0.5 mg; 1 mg)
Classification of drugs: Miscellaneous coagulation modifiers

What is Anagrelide?

Anagrelide is a medication used to treat the blood cell disorder known as thrombocythemia (also known as thrombocytosis) that occurs in the body when it produces excessive platelet cells.Anagrelide is also used for reasons not mentioned in this guideline.

Side effects of Anagrelide

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as difficulty breathing, hives, and swelling of your lips, face, tongue, throat, or face.

Anagrelide could cause severe adverse effects. Contact your doctor immediately if you suffer from:

  • Bleeding or easy bruising (nosebleeds and bleeding gums);
  • Indications of stomach bleeding: bloody or black stools, the spouting of blood or vomit that looks like coffee grounds
  • Chest pain, pressure, or
  • Rapid or pounding heartbeats, a fluttering sensation in your chest, and suddenly feeling dizzy (like you're about to pass out);
  • Breath shortness;
  • Swelling in your lower legs;
  • Blue-coloured lip or the skin.

Common adverse effects of anagrelide could include:

  • Rapid heartbeats, chest pains, breathing difficulties;
  • Numbness, tingling, burning pain;
  • Headache, weakness, dizziness;
  • Gastric pain, stomach discomfort, nausea, and lack of appetite;
  • Nausea, vomiting, diarrhoea;
  • Swelling of your feet or hands
  • The fever, cough, unwellness, coughing
  • Back pain
  • Rash, itching.

This list does not encompass every possible side effect.Other side effects could occur. Consult your physician for advice regarding medical effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.

Similar or related drugs

Agrylin, PegIntron, and PegInterferon alfa-2b

Warnings

Follow the instructions on your prescription label and on the label of your package. Inform your healthcare professionals about your medical issues, allergies, and the medicines you are taking.

Before you take this drug

Speak to your doctor if you were ever diagnosed with:

  • Bleeding issues;
  • The long qt disorder (in the case of you or a member of your family);
  • Issues with the lung or heart;
  • Liver disease
  • An unbalanced electrolyte (such as a low level of potassium present in the blood).

It isn't known if anagrelide can harm an unborn baby. Inform your doctor as soon as you suspect or plan on being pregnant.This medication can affect fertility (your capacity to have children).Breastfeeding is not advised when taking anagrelide.Anagrelide is not a drug that is approved for use by anyone less than 7 years old.

How to take Anagrelide?

Your heart's function could need to be monitored with an electrocardiograph or ECG (sometimes known as an EKG) prior to as well as during the course of treatment. You might also require regular tests of your blood while you take anagrelide.Follow the instructions on the prescription label and go through all medication guides or instructions sheets. Your doctor may alter the dosage. Make sure you take the medication exactly as prescribed.If you require surgery, inform the surgeon beforehand that you're taking anagrelide.Maintain at room temperature, far from heat, humidity, and light.

Details on dosage

Usual Adult Dose for Thrombocythemia:

In the beginning: 0.5 mg taken orally four times per day and 1 mg every day for a minimum of seven days.
Maintenance: titrate to your minimum dosage that is effective to decrease and keep the count of platelets to less than 600,000 microliters at a minimum, and then reduce it until normal. Do not increase the dose by more than 0.5 mg/day over a one-week time period.
The dose should not be more than 10 mg per day, or 2.5 mg in a single dosage.

Usual Paediatric Dose for Chronic Myelogenous Leukaemia:

Initial dosage: 0.5 mg orally daily (recommended) up to 0.5 mg orally four times a day.
Maintenance: adjust to the minimum dosage that is effective to maintain and reduce the count of platelets to less than 600,000 microliters, at a minimum, back to the normal level. Do not increase the dose by more than 0.5 mg/day over a one-week span.
The dose should not be more than 10 mg per day (or 2.5 mg in a single dosage).

Usual Paediatric Dose for Thrombocythemia:

Initial dosage: 0.5 mg orally daily (recommended) up to 0.5 mg orally four times per day.
Maintenance: adjust to the minimum dosage that is effective to maintain and reduce the count of platelets to less than 600,000 microliters, and ideally, down until normal. The dosage should be increased by no greater than 0.5 mg/day during any one-week span.
The dose should not be more than the recommended dosage of 10 mg/day, or 2.5 mg in a single dosage.

What happens if I miss the dose?

You should take the medication as quickly as you can. However, do not take any missed doses if you are nearing the time to take the next dose. Don't have two doses at one time.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Take aspirin only until your doctor has advised that you should. Follow your doctor's instructions on the dosage of aspirin to take and how often you should take it.Consult a physician or pharmacist prior to taking any medication for fever, pain, swelling, or symptoms of a cold or influenza. They could contain aspirin or other similar components (such as Ibuprofen, ketoprofen, and naproxen) that can increase the chances of bleeding.

Interaction with other drugs

Anagrelide could cause a serious heart issue. Your risk of developing heart problems is higher if you take various other medications for asthma, infections, heart conditions, high blood pressure, depression, cancer, mental illness, malaria, or HIV.

Inform your physician of all other medicines you take, such as:

  • An antidepressant
  • Medicine to improve blood flow
  • A blood thinner (such as warfarin or coumadin) or any other medication to prevent or treat blood clots
  • The nsaids (nonsteroidal anti-inflammatory drugs) are aspirin, ibuprofen (advil, motrin), naproxen (aleve), celecoxib, diclofenac, indomethacin, meloxicam, and many more.

This list isn't complete. Other medications can affect anagrelide, such as prescription and over-the-counter medicines, vitamins, and herbal products. The interactions of all drugs are included here.

 

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Prescription only

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