Amlodipine and celecoxib

What is Amlodipine and celecoxib?

Amlodipine acts as a calcium channel-blocking drug. Celecoxib is an anti-inflammatory nonsteroidal drug (NSAID).Amlodipine and celecoxib are combination medications for adults suffering from osteoarthritis as well as excessive blood pressure (hypertension).Amlodipine and celecoxib could also be used to treat conditions that are not mentioned in this guide.

Side effects of Amlodipine and celecoxib

Contact emergency medical assistance when you are experiencing symptoms or warning signs of an allergic response (hives or breathing difficulties and swelling of your throat or face) or an extreme skin reaction (fever and throat soreness, burnt eyes, irritation, and red or purple skin eruptions with peeling and blisters).Take immediate medical care. If you're experiencing indications of an attack on your heart or stroke: chest pain spreading into your shoulder or jaw A sudden feeling of weakness or numbness in one area of your body, speech slurred, leg swelling, and feeling tired

Amlodipine and the celecoxib combination could have serious negative side effects. Take off celecoxib and amlodipine and consult your physician immediately if you suffer from:

• Nausea or weakness; sensation of tingling;
• Acute or new chest pain,
• The initial sign of an itchy rash, no matter how minor;
• Rapid weight increase, feeling short of breath;
• Swelling in your hands, feet, legs, or arms;
• Symptoms of stomach bleeding: bloody or tarry stool, and vomiting blood or vomiting that appears like coffee grounds
• Issues with the liver, such as stomach discomfort (upper right side) or dark urine jaundice (yellowing of the eyes or skin),
• Low red blood cells (anemia)—pale skin and fatigue; sensations of being lightheaded; cold hands and feet

Common adverse reactions to amlodipine and celecoxib can include:

• Stomach discomfort, heartburn, gas, diarrhoea, nausea, stomach pain, heartburn, gas, diarrhoea;
• Drowsiness, feeling tired;
• Swelling;
• Increased urination
• Joint pain;
• Rash;
• Flushing (sudden redness or warmth in the area of your face);
• Headache, dizziness,
• Symptoms of the cold, like nasal stuffiness, sneezing, and a sore throat.

This is not a comprehensive list of possible side effects, and other side effects could occur. Contact your physician to seek medical advice on adverse effects. If you experience any adverse reactions to the FDA by calling 1-800-FDA-1088.

Similar/related drugs

Amlodipine, Lisinopril, Metoprolol, Losartan, Aspirin, Prednisone, and Ibuprofen

Warnings

Celecoxib may increase the chance of suffering fatal coronary heart attacks as well as strokes. Avoid using this medication prior to or following heart bypass surgery (coronary bypass grafts for the artery, or CABG). Celecoxib can cause diarrhoea or stomach bleeding and may cause fatal bleeding.

Prior to use this drug

Celecoxib could increase your chance of having a fatal stroke or heart attack, even if you do not have an underlying risk factor. Don't take amlodipine or celecoxib prior to or after the procedure for heart bypass (coronary bypass graft for artery bypass, also known as CABG).Celecoxib may cause stomach or intestinal bleeding, which can lead to death. These issues can happen at any time, even without warning, when you are taking amlodipine or celecoxib, especially among older adults.

This medicine if you're allergic to the drugs amlodipine (Norvasc) or celecoxib (Celex) or:

• An allergy to the sulfa-containing drugs
• A past history of an asthma attack or a evere allergic reaction following an allergic reaction after taking aspirin or an NSAID

Inform your doctor if you were ever diagnosed with:

• It could be a stomach ulcer or bleeding from your stomach or in your intestines.
• Bleeding issues;
• Heart issues, coronary artery disease;
• Kidney or liver disease
• If you smoke or drink alcohol,

If you are expecting, then you shouldn't take celecoxib unless your doctor advises that you should. Taking an NSAID in the last 20 weeks before birth may cause kidney or heart issues in the baby and possibly complications in the pregnancy.This medication may alter the fertility (ability to have children) of women. Consult your physician about this possibility.It might not be safe to breastfeed while taking this medication. Consult your physician about any potential risks.

How to take Amlodipine and celecoxib?

Follow the directions on the prescription label and go through all medication guides or instructions. Your doctor might modify your dose. Choose the dose that works for treating your condition.It is possible to take this medication in combination with food or not.The blood pressure of your patients should be regularly monitored.It is possible that you will experience an increase or worsening in chest pain as you begin to take this medication or after you increase your dosage. Contact your physician if the chest pain you experience is intense or continues to persist.Use amlodipine and celecoxib even if you feel good. Do not alter your dosage or schedule of dosing without consulting your physician.Keep it at room temperature, free of heat and moisture.

Details on dosage

Usual Adult Dose for Hypertension:

The first dose is: amlodipine (5 mg) and celecoxib (200 mg) once daily orally.
The maximum dose is: amlodipine 10 mg; celecoxib 200 mg once daily orally.
Comments: Allow 7–14 days between the titrations. If a faster titration rate is needed clinically, be sure to monitor closely.

Usual Adult Dose for Osteoarthritis:

The first dose is: amlodipine (5 mg) and celecoxib (200 mg) once daily orally.
Dosage maximum: Amlodipine 10 mg; Celecoxib 200 mg, taken orally every day.
Comments: Allow 7–14 days between the titrations. If a more rapid titration is required clinically, follow closely.

Usual Geriatric Dose for Hypertension:

The first dose is: amlodipine 2.5 mg; celecoxib 200 mg once daily orally.
Dosage maximum: Amlodipine 10 mg; Celecoxib 200 mg, taken orally every day.
Comments: Allow 7–14 days between the titrations. If a more rapid titration is needed clinically, be sure to monitor closely.

Usual Geriatric Dose for Osteoarthritis:

Dosage for the first time: amlodipine 2.5 mg and celecoxib 200 mg, taken orally every day.
Dosage maximum: amlodipine 10 mg; celecoxib 200 mg once daily orally.
Comments: Allow 7–14 days between the titrations. If a faster titration rate is needed clinically, be sure to monitor closely.

What happens if I miss the dose?

Do not take the medicine for as long as you can. However, do not take your missed dose if it's nearing the time to take the next dose. Don't take two doses at a time.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.Overdose symptoms can consist of nausea, vomiting, and stomach discomfort; dizziness; rapid heartbeats; warmth or redness in your legs, arms, or feet; as well as feeling faint.

What should be avoided?

Beware of taking aspirin and similar non-steroidal antidepressants without consulting your physician.Beware of drinking alcohol. It can increase the risk of bleeding in your stomach.Talk to your doctor or pharmacist prior to using any other medications for swelling, pain, fever, or flu symptoms. These medicines may contain ingredients that are similar to celecoxib (such as aspirin, ibuprofen, ketoprofen, and naproxen).

Interaction with other drugs

Inform your doctor about all other medications, including:

• Any other blood pressure medication, such as diuretics or "water pills,"
• Any kind of steroid medication;
• An antidepressant
• Heart medicine
• A blood thinner – warfarin, Coumadin, Jantoven

The list below is not exhaustive, and a variety of other medications could influence celecoxib and amlodipine. This includes over-the-counter and prescription medications, vitamins, and herbal products. The list of possible drug interactions is not exhaustive. are included here.