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Amlodipine and benazepril

Generic name: amlodipine and benazepril [am-LOE-di-peen-and-ben-AY-ze-pril]
Brand name: Lotrel
Dosage form: oral capsule (10 mg-20 mg; 10 mg-40 mg; 2.5 mg-10 mg; 5 mg-10 mg; 5 mg-20 mg; 5 mg-40 mg)
The class of drugs: ACE inhibitors with calcium channel blocking agents

What is Amlodipine and benazepril?

Amlodipine can be described as an inhibitor of calcium channels. Amlodipine is a relaxer that widens blood vessels and increases blood flow.Benazepril has been identified as an ACE inhibitor. ACE stands for angiotensin-converting enzyme. Benazepril additionally increases blood vessel size and stops the body from holding water.Amlodipine and benazepril are combination medicines that treat the problem of high blood pressure (hypertension).Amlodipine and benazepril can also be used for other purposes that are not mentioned in this guide.Amlodipine and benazepril's adverse consequencesTake immediate medical attention. If you exhibit symptoms that indicate an allergic reaction, such as an allergic reaction that causes hives, extreme stomach pain, breathing difficulties, and swelling of your lips, face, tongue, throat, or face, You are more likely to suffer from a reaction to an allergen if you are African-American.Certain side effects might not be noticed until you've been taking the medication for a few months.

Amlodipine and benazepril could cause serious adverse side effects. Contact your physician immediately. If you suffer from:

  • Feeling lightheaded, like you're about to pass out.
  • Swelling in your hands and feet; weight gain rapid;
  • Acute or new chest pain,
  • Fever and chills throat sore and body aches symptoms of flu symptoms;
  • High potassium—nausea and fatigue, tingling sensations, and chest pain. It can also cause irregular heartbeats, a lack of motion,
  • Stomach pain (upper right side), itching and fatigue, and unusual symptoms bloody colour of urine, jaundice (yellowing of the eyes or skin).

Common side effects of amlodipine or benazepril could include:

  • Cough;
  • Dizziness;
  • Swelling of your feet or hands.

There isn't an exhaustive listing of the various negative effect Other side effects could occur. Consult your physician to seek medical advice on adverse effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.


Avoid using it in the case of pregnancy. If you find yourself pregnant, you should stop taking amlodipine and benazepril and inform your doctor immediately.It is not recommended to use this medication if you've ever suffered from angioedema. Don't take the medication within 36 hours of taking a medication that includes sacubitril (such as Entresto).If you suffer from diabetes, avoid taking benazepril and amlodipine in conjunction with any medication containing an ingredient called aliskiren (a blood pressure medication).

Prior to use this drug

You shouldn't make use of this medication if you are sensitive to amlodipine, benazepril,

  • You've experienced angioedema (hives or extreme swelling of the deep skin tissues, often due to an allergic reaction).
  • You recently had an anti-heart medicine known as sacubitril.
  • You are allergic to other ACE inhibitors, like captopril, enalapril, lisinopril, moexipril, benazepril, quinapril, ramipril, Accupril, Prinivil, Mavik, Vasotec, and many others.

Don't take amlodipine or benazepril for a period of 36 hours prior to or after taking medication that has sacubitril (such as Entresto).If you suffer from diabetes, don't take benazepril or amlodipine with any other medication that has the ingredient aliskiren (a blood pressure medication).There is a possibility that you should not take amlodipine or benazepril along with Aliskiren when you suffer from kidney problems.

Inform your doctor if you have ever suffered from:

  • The heart condition, also known as congestive heart failure,
  • The potassium levels are high in your blood (hyperkalemia);
  • Renal disease (or if you're on dialysis);
  • Liver disease
  • If you're on a diet that has low salt,

Do not take this medicine when you are expecting. If you are pregnant, then stop taking this medicine and inform your doctor now. Benazepril can cause injury or even death to an unborn baby if you use the medication during your third or second trimester.It is not recommended to breastfeed while you take this medicine.

How to take Amlodipine and benazepril?

Follow the directions on the prescription label and review all medication guides and instructions. The doctor might alter your dosage. Follow the medication exactly as prescribed.Amlodipine is a medicine that you can take along with benazepril in combination or without food. The medicine should be taken together throughout the day.Vomiting, diarrhoea, or heavy sweating can cause you to be dehydrated. Drink plenty of water every day while taking benazepril and amlodipine.Your blood pressure needs to be monitored frequently. You may also require regular blood tests.If you require surgery, be sure to inform your doctor that you are currently taking this medication. It is possible that you will need to stop the procedure for a brief period of time.Contact your physician if you have persistent vomiting or diarrhoea or if you're sweating more than normal. It is possible to get dehydrated when taking benazepril and amlodipine. This can result in very low blood pressure as well as electrolyte issues or kidney failure.Continue to take this medication as prescribed, regardless of whether you are feeling well. A high blood pressure can have no signs. You could need medication for blood pressure throughout your life.Place it in a cool, dry place free of heat and moisture.

Details on dosage

Usual Adult Dose for Hypertension:

Dose for the first time: amlodipine 2.5 mg; benazepril 10 mg, taken orally every day.
Dosage for maintenance: amlodipine 2.5 to 10 mg; benazepril 10 to 40 mg once orally every day.
Maximum dose: Amlodipine: 10 mg/day; Benazepril: 80 mg/day
Increase the dose after 2 weeks if needed to reach the blood pressure goal.
Benazepril in combination with amlodipine is not expected to result in an additional reduction in blood pressure for African Americans.

Side effects of Amlodipine and benazepril

Do the medication as quickly as you can. However, avoid any missed dosage if you have been more than twelve hours late for the dose. Don't take two doses in one go.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Consuming alcohol with amlodipine or benazepril could cause adverse reactions.Avoid driving or engaging in hazardous activities until you understand the effects of this medication on your body. Your reaction could be affected.Don't use sodium substitutes or potassium supplements when taking benazepril and amlodipine, unless your doctor has advised you to.

Interaction with other drugs

There are times when it's not recommended to take certain medications in combination. Certain medications can alter the blood levels and the other drugs you are taking, which could create side effects or render the drugs less effective.

Discuss with your doctor your current medications. A variety of drugs can interact with amlodipine and benazepril. These include:

  • Lithium;
  • Probenecid;
  • Simvastatin;
  • A diuretic, or "water pill";
  • Gold injections for the treatment of the symptoms of arthritis;
  • Heart or blood pressure medication;
  • Insulin, or oral diabetes medicine;
  • An antibiotic—clarithromycin, telithromycin;
  • Antifungal medicine: itraconazole, ketoconazole;
  • Antiviral medicine for treating an infection known as hiv/aids; the antiviral medication for treating hiv/aids; the drugs indinavir, ritonavir, and other medications;
  • Medicine to stop organ rejection to transplants: cyclosporine everolimus sirolimus tacrolimus, temsirolimus
  • The nsaids (nonsteroidal anti-inflammatory drugs) are aspirin, ibuprofen, aspirin (advil, motrin), naproxen (aleve), celecoxib, diclofenac, indomethacin, meloxicam, and a few others.

This list isn't complete, and other drugs could influence benazepril and amlodipine. This includes both over-the-counter and prescription drugs, vitamins, and herbal products. There are many possible interactions between drugs that are listed here.