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Name of the generic: amifampridine [AM-iFAM-pri-deen
Name of the brand: The Firdapse
Dosage Form: oral tablet (10 mg)
Drug class: cholinergic muscle stimulants

What is Amifampridine?

Amifampridine is a treatment for the myasthenic condition Lambert-Eaton in adults.Amifampridine is also used for reasons not mentioned in this guideline.

Side effects of Amifampridine

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms or warning signs of an allergic response, such as difficulty breathing, hives, or swelling of your lips, face, or tongue.Amifampridine can trigger seizures even if you have never experienced a seizure before.\Stop using amifampridine immediately, and call your doctor immediately when you're experiencing seizures.

Common side effects of amifampridine can include:

  • Tingling sensation in your feet, hands, face, or any other area of your body.
  • Nausea, nausea, stomach pain, diarrhoea,
  • Headache, back pain;
  • Elevated blood pressure
  • Abnormal tests of liver function;
  • Muscle spasms
  • Symptoms of the cold, like nasal stuffiness, sneezing, and sore throats.

The following isn't an exhaustive list of the possible reactions, as other reactions could be experienced. Speak with your doctor to get medical advice regarding adverse reactions. If you experience any side reactions to the FDA by calling 1-800-FDA-1088.


Amifampridine can trigger seizures even if you've not had any before. Stop taking amifampridine and contact your doctor if you are experiencing seizures.

Prior to use this drug

Amifampridine should not be used in the event that you are allergic to it, or:

  • You've had seizures in the past.
  • You are sensitive to the chemical dalfampridine.

Consult your doctor If you've ever had:

  • A seizure;
  • The liver condition;
  • Kidney disease
  • If you take another form of amifampridine that you can purchase from the pharmacy that compounded it (3,4-diaminopyridine, also known as 3,4-DAP),

Inform your doctor if you are nursing or pregnant.

How to take Amifampridine?

Follow the directions on the prescription label and go through all medication guides or instructions. The doctor might alter your dosage. Follow the medication exactly as prescribed.Amifampridine is a drug that can be taken either with or without food.Don't take more than two tablets at once. Don't take more than 8 tablets within 24 hours.The amifampridine tablet is able to be split in two if required.

Maintain it at room temperature, clear of moisture and heat.Discard any amifampridine that has not been utilised prior to the expiration date. end date on the label of the medicine.

Details on dosage

Usual Adult Dose for Lambert-Eaton Myasthenic Syndrome:

Initial dosage: 15 to 30 milligrammes daily, in split doses (3–4 times a day).
Maximum single dose: 20 mg
Maximum daily dose: 80 mg/day
The dose can be increased by 5 mg over the course of 3–4 days.
If a dose is missed, the patient should not take more than one dose or double it.
Use: To treat Lambert-Eaton myasthenic disorder (LEMS)

Usual Paediatric Dose for Lambert-Eaton Myasthenic Syndrome:

From 6 to 17 years old, weighing less than 45kg:
Initial dosage: 7.5 mg to 15 mg once daily in doses that are divided (2 or 3 times a day).
Maximum single dose: 15 mg
Maximum daily dose: 50 mg
The dose can be increased in 2.5 mg increments from 5 mg to 2.5 mg and divided into 5 doses per day.
Dosage should be increased depending on the response of patients and their tolerance.
A suspension is prepared for patients who require a dose smaller than 5 mg per increment.
Between 6 and 17 year old, weighing up to at least 45kg:Initial dosage Between 15 and 30 mg in split portions (2 or 3 times per day)
Maximum single dose: 30 m
Maximum daily dose: 100 mg
Dose can be increased by 5 mg–10 mg increments and divided into 5 doses per day.
Dosage should be increased based on clinical response and tolerance.
Use: To treat Lambert-Eaton myasthenic disorder (LEMS)

What happens if I miss the dose?

Don't miss the dose you missed, and take your next dose at your regular time. Do not take two doses at once.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Follow the doctor's advice regarding any restrictions on your food, drink, or any activity.

Interaction with other drugs

Amifampridine can trigger seizures, especially if you are taking other medications to treat infections like asthma, depression, mental illness, attention deficit disorder, or severe pain.Amifampridine is a drug that can be affected by a variety of drugs. This includes prescription as well as over-the-counter medications, vitamins, and herbal supplements. The interactions between these products are not mentioned here. Discuss with your physician all the medicines you are currently taking and any medication you begin or stop taking.




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