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Acetic Acid Irrigation 

Dosage Form: Irrigation
Class of Drugs: Topical anti-infectives

What is Acetic Acid irrigation?

0.25 percent Acetic Acid Irrigation USP is a safe aqueous solution that is non-pyrogenic and contains glacial acetic acid (USP) to irrigate the urinary bladder via the transurethral method (not to be used for the TUR). Each 100 mL contains 250mg of glacial acetic acid in a solution of water suitable for injection.The solution is hypotonic and has 42 MOsmol/L (calc.) with respect to the extracellular fluid compartment in the human body (280 MOsmol/liter), and it has a pH of 3.1 (2.8 up to 3.4).

Apart from the active ingredient, acetic acids The solution does not contain antimicrobials, bacteriostats, or additional buffers and is intended to be used as a one-dose irrigation. If smaller quantities are needed, then the portion that is not used should be removed.The remedy is a urinary bladder antimicrobial and acidification of the irrigant.Glacial Acetic Acid USP is chemically referred to as acetic acid (C2H4O2), an insoluble liquid that is miscible with water. Its basic formula for its structure is:


The chemical formula for water injection is called H2O.

The semi-rigid containers are made using a polyolefin that has been specially designed. It's a copolymer made of propylene and ethylene. It does not require barriers to vapours in order to maintain the right concentration of drugs.A solution that comes into contact with a plastic container can release some chemical elements from the plastic in small amounts. Nevertheless, biochemical tests proved positive for the safety of the materials used in plastic containers.

Temperatures above 25 degrees Celsius (77 degrees Fahrenheit) when stored or transported could result in small losses in the moisture content. More extreme temperatures cause more losses. These tiny losses will not cause any clinically significant change within the period of expiration.


  1. The use of this remedy in patients who suffer from lesions of the mucosa in the urinary bladder can cause irritation caused by the lesions. The absorption of the solution through open lesions in the mucosa of the bladder can lead to systemic acidosis.
  2. The contents of an unopened container must be disposed of promptly in order to reduce the risk of bacterial growth or pyrogen creation.
  3. You can dispose of any leftover water irrigating solution because it has no preservation agent.
  4. Avoid heating above 66°C (150 °F).

Before you take This Drug

The irrigation of the bladder by acetic acid solutions at a concentration of 0.25 percent was found to provide antimicrobial benefits against various microorganisms (especially ammonia-forming bacteria) that are often able to get access to the urinary tract for patients requiring prolonged indwelling of urethral catheters. The antimicrobial effect of the solution is contingent on the use of a catheter in the indwelling system at a suitable quantity (continuous as well as intermittent) in order to keep an effluent's pH at a minimum of 5.0. Maintaining a low pH in bladder urine is also helpful in reducing the development of calcium encrustations inside the indwelling catheter.

How to Take Acetic Acid Irrigation?

0.25 percent acetic acid irrigation USP is suggested for use as a continuous or intermittent bladder rinse that helps in preventing the growth and spread of urinary pathogens susceptible to infection (especially ammonia-producing bacteria) to treat patients that require the long-term use of an indwelling urinary catheter. Additionally, it can be utilised to provide periodic watering of the

Details on dosage

0.25 percent acetic acid irrigation USP is administered through gravity drip using an administration device that is connected to a urinary catheter that is designed to provide regular or irregular two-way flow. A dispensing kit that is disposable must be employed. A piston or bulb syringe can be utilized for the frequent irrigation of the inside catheter.

If you are using intermittent or continuous irrigation, the frequency of administration is approximately proportional to the flow of urine and must be adjusted so that it maintains the pH of urine effluents between 4.5 and 5.0. Nitrating and other pH papers can be utilized to measure the pH of the urine every day, at least four times. The rate of drip should be adjusted according to need in order to maintain the desired ph. An increase in flow lowers pH and reverses If you are using intermittent or continuous irrigation, patients require about 500–1000 mL every day for 24 hours.To ensure that indwelling tubing has patency, around 50 mL are needed for every irrigation. It can be administered with a piston or a bulb syringe to be injected and aspirated at the frequency you desire.

The parenteral product must be examined visually to detect discoloration or particulate matter before administration, if the solution and container allow. See PRECAUTIONS.

What Happens  if I Overdose?

The risk of absorption through the system is low in the absence of open cysts of the bladder mucosa that are not being detected. If this is the case, stop the irrigator and evaluate the patient for any possible signs of the presence of systemic acidosis, intravascular bleeding, or circulatory overload. Then, implement suitable countermeasures if needed. See Warnings, Precautions, and Adverse Reactions.

The oral LD50 of mice is 5 grams/kg.

What Should be Avoided?

If there is pain or hematuria that should be observed during irrigation, the procedure should be stopped and the patient should be re-evaluated.Don't use it until the solution is clear, the seal is in place, and the container is unharmed. Don't throw away any unneeded portions.

Nursing mothers: Beware needs to be maintained during the time Acetic Acid Irrigation USP is given to nursing mothers.

Pregnancy: Teratogenicity Effects Pregnancy Categorized C. Studies on reproduction in animals have never been conducted using acetic acid irrigation (USP. There is no information on the possibility that acetic acid irrigation, USP, can cause harm to a fetus when given to an expecting woman or impact reproduction. Acetic Acid Irrigation USP is recommended for pregnant women only when absolutely necessary.

Pediatric Use: The safety and efficacy of this product haven't been confirmed. The limited usage of this drug in children's patients has not allowed for the proper dosages and limits for its use.

Interaction with other drugs


It is not recommended when it comes to irrigation during transurethral surgery procedures.

Carcinogenesis Mutagenesis impairment or impairment of fertility: Research studies using acetic acid irrigation, USP, have not been conducted to assess carcinogenic or mutagenic risk or the consequences on fertility.