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Name of the generic: Diclofenac diclofenac dye-KLOE’-fen-ak diclofenac [dye-KLOE-fen-ak]
Names of brands: Cambia, Cataflam, Lofena, Zipsor, and Zorvolex
Class of drug: Nonsteroidal anti-inflammatory drugs

What is Zorvolex?

Zorvolex is an anti-inflammatory medication that is nonsteroidal (NSAID) and is prescribed for treating mild to moderate pain as well as symptoms and signs of osteoarthritis.

Zorvolex powder (Cambia) is used to treat the symptoms of a migraine attack. Cambia can only treat the symptoms of a migraine that have already started. It won't stop headaches or decrease the frequency of attacks.Zorvolex can be used for other purposes not covered in this medication guide.

Side effects of Zorvolex

Contact emergency medical assistance. If you notice symptoms warning signs of an allergic response (hives and breathing problems or swelling of your throat or face) or a severe reaction to your skin (fever and burning eyes, sore throat, and skin irritation, as well as an ailment that is purple or red with peeling and blisters),

Stop taking Zorvolex and seek medical attention in the event of a serious drug reaction that could affect the body in a variety of ways. Symptoms may include the appearance of a skin rash or fever, swollen glands, muscle aches, extreme weakness, unusual bleeding, or an increase in the color of your eyes or skin.

Take immediate medical care. If you are experiencing indications of a stroke or heart attack, chest pain spreading into your shoulder or jaw A sudden feeling of weakness or numbness in one area of your body, slurred speech, or feeling breathless.

Zorvolex can cause serious adverse effects. Stop taking Zorvolex and contact your physician immediately in the event that you experience:

  • The very first indication of any rash on the skin, regardless of how minor;
  • Flu-like symptoms;
  • Heart conditions: swelling; rapidly gaining weight; sensation of being short of breath;
  • Kidney issues: no or little urination; hard or painful to urinate; swelling in your legs or arms; being tired or sluggish;
  • Liver issues: nausea, diarrhea, and stomach discomfort (upper right side) fatigue, itching, dark urine, jaundice (yellowing of the eyes or skin) problems,
  • Indications of stomach bleeding: bloody or black stools, the spouting of blood, or vomiting that resembles coffee grounds.

Common adverse effects of Zorvolex could be:

  • Indigestion, gas, nausea, vomiting, and stomach pain;
  • Diarrhea, constipation;
  • Headache, dizziness, or drowsiness;
  • Abnormal lab tests;
  • Itching, sweating;
  • Stuffy nose;
  • Elevated blood pressure;
  • The pain or swelling of your legs or arms.

This isn't an exhaustive list of all the side effects. Other side effects could occur. Contact your physician for advice regarding medical effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


Zorvolex could increase your risk of having a fatal coronary heart attack or stroke. Don't use Zorvolex prior to or following the heart bypass surgery (coronary bypass graft for the artery, also known as CABG). This medication can also trigger stomach or intestinal bleeding, which could be fatal.

Before you take this drug

Zorvolex may increase the chance of having a fatal heart attack or stroke, even if you do not possess any risks. Don't take this medication immediately prior to or after the procedure for coronary bypass grafts (also known as CABG).

Zorvolex may cause stomach or intestinal bleeding, which could be fatal. These problems can develop at any time while taking this medicine and are more common among older adults.You shouldn't make use of Zorvolex in the event that you are sensitive to it or if you've ever experienced an asthma attack or a severe allergic reaction following the use of aspirin or an NSAID.

Don't use Cambia to treat cluster headaches. Don't use Zipsor if you're sensitive to beef protein.

Speak to your doctor if you have ever suffered from:

  • The heart condition, high blood pressure;
  • The bleeding or ulcers in your stomach;
  • Asthma;
  • Kidney disease or liver failure,
  • If you smoke.

Zorvolex can alter ovulation and may make it harder to become pregnant when you're taking this medication.

If you are expecting and you are taking Zorvolex unless your physician tells you not to, Taking an NSAID in the final twenty weeks of pregnancy may result in serious kidney or heart issues in the baby and possibly complications in the pregnancy.It might not be safe to breastfeed while taking this medication.Consult your physician regarding the potential dangers.Zorvolex is not permitted for use by anyone less than 18 years old.

How to take Zorvolex?

Different kinds of diclofenac contain different levels of Zorvolex. They also have different applications. If you switch brands, your dosage requirements could be different. Follow the instructions of your doctor about the dosage of medicine you should take. Consult your pharmacist if you have any questions regarding the type of diclofenac you get from the pharmacy.Follow the instructions on the prescription label, and make sure you read the entire medication guide. The doctor could alter the dosage. Make sure you take the dosage that is effective in treating your condition.Take your tablet whole and don't crush, chew, or break it.Consume Zorvolex on an empty stomach at least one hour prior to or two hours after the meal.

Does Zorvolex Powder (Cambia) by mixing 1–2 ounces of water. Don't use any other kind of liquid. Mix this mixture well and drink it all immediately. This medicine powder is best when you drink it on a full stomach.Consult your physician if your headache doesn't completely disappear when you take Cambia.If you take Zorvolex for a long time, it is possible that you will require frequent medical tests.Place in a cool, dry place free of moisture and heat. Close the bottle when not being used.

What happens if I miss a dose?

Do the dose you missed as quickly as you can remember. Avoid your missed dose if you are close to the time of the next dose. Don't take additional medicine to make up for the missed dose.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

Avoid this

Beware of drinking alcohol. This can increase your chance of bleeding from your stomach.Do not take aspirin or any other non-steroidal antidotes except if your physician has told you to.

Consult a physician or pharmacist before taking other medicines to treat swelling, pain, fever, and other symptoms of the cold or flu. They could contain ingredients like Zorvolex (such as aspirin, ibuprofen, ketoprofen, and naproxen).

Interaction with other drugs

Talk to your doctor prior to taking Zorvolex when you are taking any antidepressant. Taking certain antidepressants together with an NSAID can cause bleeding or bruising.

Inform your doctor about any other medications you take, including:

  • Blood pressure or heart medication such as diuretics or "water pills";
  • Other variants of Zorvolex in different forms (Arthrotec, Flector, Pennsaid, Solaraze, Voltaren Gel);
  • One of them is warfarin, Coumadin, Jantoven,
  • Other nsaids: aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), indomethacin, Meloxicam, and many more.

This list isn't exhaustive. Other drugs can interact with Zorvolex, such as medications that are prescribed and available over the counter, vitamins, and herbal products. There are many possible interactions between drugs that are listed here.



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