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Generical Name: Dexrazoxane dex-ray-ZOX-ane [dex-ray-ZOX-ane]
The class of Drug: Miscellaneous uncategorized agents

What is Zinecard?

Zinecard is a product used to safeguard organs like the heart from the harmful adverse effects triggered by some cancer drugs.The Totect brand of dexrazoxane is used in men and women to treat a condition called extravasation (es-TRA-va-ZAY-shun). Extravasation occurs when injected medicine is released from blood vessels and flows through the body's tissues. The risk of serious tissue damage is high in the event of extravasation following the injection of certain chemotherapy drugs.

Zinecard can also aid in preventing heart problems related to chemotherapy when women are taking the drug doxorubicin to treat metastatic breast cancer. Zinecard is only given when you've received sufficient infusions of doxorubicin that amount to a particular total dose.Zinecard can be used to treat other conditions that are not covered in this medication guide.

Side effects of Zinecard

Contact emergency medical assistance. If you are experiencing symptoms that indicate an allergic reaction, such as difficulty breathing, feeling lightheaded or achy, and swelling of your lips, face, tongue, or throat,

Zinecard can cause severe adverse reactions. Contact your doctor immediately if you suffer from:

  • Fever, chills, tiredness, mouth sores, and skin sores;
  • Simple bleeding, unusual bruising;
  • Sore throat, cough, trouble breathing, or sore throat
  • There may be swelling, bruising, bleeding, redness, or bleeding from an incision.

Common adverse consequences of Zinecard could include:

  • Nausea, vomiting;
  • Fever;
  • Infection following an operation
  • There was pain where the medicine was injected.

It's not a comprehensive listing of the various negative effect. Other effects may also be present. Consult your physician to seek medical advice on the effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.

Similar or related drugs



Zinecard could cause harm to an unborn child or cause birth problems if the mother or father uses it. Inform your caregivers if you are pregnant or if you're male and your sexual spouse is likely to become pregnant.

It is not recommended to get Zinecard in the event that your treatment is not based on doxorubicin or a similar drug (such as daunorubicin, epirubicin, idarubicin, and mitoxantrone).

Inform your doctor immediately when you show symptoms of infection, such as chills, fever, and sore throats. Also, you may experience bleeding, bruising, skin lesions, or the redness and warmth of any surgical cut.

Before you take this drug

It is not recommended to receive Zinecard in the event that your chemotherapy doesn't include doxorubicin or another similar medication like:

  • Daunorubicin (Cerubidine, Daunoxome);
  • Epirubicin (Elence);
  • Idarubicin (idamycin);
  • Mitoxantrone (Novantrone).

Speak to your doctor if you have ever suffered from:

  • Heart issues;
  • The liver condition
  • Kidney disease.

Zinecard may harm a baby who is not born as well as cause birth defects if the father or mother is taking this medication. Women should use efficient contraception to stop pregnancy when receiving this medication and for at least six months following their last dosage. Men should also use birth control while receiving treatment and for at least 3 months after taking the previous dose. Inform your doctor immediately if you become pregnant during this period.

This medication can affect fertility (the ability to have children) in men. It is nevertheless important to use birth control in order to avoid pregnancy, as Zinecard can cause harm to the baby if there is a pregnancy.

It is not recommended to breastfeed while using Zinecard. Women who are taking Totect are advised not to breastfeed for at least 2 weeks after their last dose.

How to take Zinecard?

Zinecard is injected as an infusion into the vein. The healthcare professional will give the injection.Totect is typically started within six hours of the exovasation and is continued every three days for three consecutive days.

Zinecard is usually initiated 15 minutes prior to the time you receive your doxorubicin injection. Zinecard is not included when you receive your initial dose of doxorubicin; however, it is only given after receiving prior doses of doxorubicin that exceed the amount of a specific total.

Zinecard may contribute to bone swelling due to chemotherapy. There is a chance that you will contract infections more frequently, even severe or fatal infections. Your doctor should test you regularly.

What happens if I miss a dose?

Because Zinecard is prescribed by a medical professional in conjunction with the chemotherapy regimen, it is unlikely to skip the dose.

Contact your doctor for advice. If you missed your appointment for chemotherapy.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

Avoid this

Beware of those with illnesses or suffering from infections. Inform your doctor immediately in the event that you show symptoms of an infection.

Interaction with other drugs

Inform your doctor about all other medicines you take, particularly:

  • Other medications for cancer other cancer medications
  • Dimethyl sulfoxide (DMSO).

This list isn't complete. Other medications can affect Zinecard, including medications that are prescribed and available over the counter, vitamins, and herbal products. There are many possible interactions between drugs that are listed here.