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Generic Name: Lisinopril Lisinopril lyse IN-oh-prillyse-IN”-oh-pril
Dosage Format: Oral tablet (2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg, and 40 mg).
Drug Class: Angiotensin-converting enzyme inhibitors

What is Zestril?

Zestril (lisinopril) is taken on its own or in conjunction with other medicines in order to manage hypertension in children and adults six years of age and older.Zestril is also prescribed to adult patients to manage constricted heart disease and to prolong the time following a cardiac attack.

Zestril belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It is a drug that reduces certain substances that enlarge blood vessels, ensuring that blood flows more easily and the heart is able to pump blood more efficiently.


Do not take Zestril if you are expecting. It could harm the unborn baby. Stop taking this medicine and notify your doctor when you begin to become pregnant.You shouldn't make use of this medicine if you've had any angioedema in the past. Don't take Zestril in the 36 hours prior to or after using a medicine that has sacubitril (such as Entresto).

If you suffer from diabetes, don't use Zestril in conjunction with any other medication containing an aliskiren (such as Amturnide, Tekturna, or Tekamlo).It is also possible to stay clear of taking Zestril with the aliskiren in the event that you suffer from kidney problems.

Before you take this drug

You shouldn't make use of Zestril when you have an allergy to lisinopril or another ACE (angiotensin-converting enzyme) inhibitor such as captopril, fosinopril, enalapril, benazepril, moexipril, perindopril, quinapril, ramipril, or trandolapril.

Don't take Zestril for more than 36 hours prior to or after taking a medicine that includes sacubitril (such as Entresto).If you suffer from diabetes, don't take Zestril alongside any medicine that has the ingredient aliskiren (a blood pressure medication).

Don't take Zestril if you are a victim of angioedema (a severe allergic reaction).To be sure Zestril is appropriate for you, ask your doctor if you have ever experienced:

  • The heart, heart disease, and heart issues like a recent heart attack
  • Low blood pressure;
  • Low white blood cell count;
  • Stomach pain;
  • If you're on a diet that has low salt levels,
  • Diabetes;
  • The liver condition
  • Kidney disease (or those who are taking dialysis).

You might also have to stay away from taking Zestril with Aliskiren if you suffer from kidney problems.

Stop using this medication and inform your doctor if you find yourself pregnant. Zestril can cause harm or even death to the unborn child if you use the medication during the third or second trimester.

Do not breastfeed.

Similar or related drugs

amlodipine, lisinopril, metoprolol, losartan, aspirin, furosemide, and carvedilol

How to take Zestril?

Use Zestril exactly as directed by your physician. Follow the instructions on the label of your prescription and study all prescription guides and instruction sheets. The doctor could modify your dosage.It is possible to use Zestril in combination with food or not.Your blood pressure needs to be monitored regularly, and you could require regular blood tests.Speak to your doctor if you have any planned procedures.

Contact your physician if you are experiencing persistent diarrhea or are sweating more than normal. You are likely to dehydrate when taking Zestril. This can result in high blood pressure levels, electrolyte imbalance, or kidney failure.If you suffer from hypertension, you should continue taking Zestril even if you're feeling good. The presence of high blood pressure is often accompanied by no signs.Close the storage tightly to room temperatures, far from heat and moisture. Don't freeze.

Details on dosage

Usual Adult Dose for Hypertension:

Initial dosage: 10 mg taken daily orally; 5 mg orally every day.
Dosage for maintenance is 20 to 40 mg once orally every day.
Maximum dosage of 80 mg, taken orally at least once per day.
The initial dose is 5 mg orally every day for patients taking diuretics.
The dose of 80 mg is taken, but it does not appear to provide more effect.
If blood pressure cannot be managed using Zestril by itself, a small dose of diuretics can be added (e.g., hydrochlorothiazide, 12.5 mg). Following the addition of a diuretic, it could be feasible to decrease the dosage of Zestril.

Usual Adult Dose for Congestive Heart Failure:

Initial dosage: 2.5 to 5 mg daily, orally
Dosage for maintenance: It is to be increased if tolerated.
Maximum dosage: 40 mg orally every day, once
The diuretic dosage may have to be adjusted to lessen hypovolemia, which could cause hypotension. Hypotension that is evident after the first dose of Zestril does not mean that it is impossible to continue cautious dose titration of the drug.

Usual Adult Dose for Myocardial Infarction:

Initial dosage: 5 mg in a single dose (within 24 hours after the beginning of the acute myocardial infarction).
The next dose is 5 mg taken orally within 24 hours, followed by 10 mg orally within 48 hours.
The maintenance dose is 10 mg every day. The dosage should be maintained for at least 6 weeks.
The therapy should be started at 2.5 mg in patients who have a blood pressure that is low (less than 120 mm Hg or more than 100 mm Hg) within the first three days following the infarct. If hypotension persists for a long time (systolic blood pressure below 90 mmHg for longer than 1 hour), therapy should be discontinued.
Benefits: reduced mortality from acute myocardial infarction.

Usual Adult Dose for Diabetic Nephropathy:

Initial dosage: 10–20 mg once orally every day.
Dosage for maintenance: 20 to 40 mg once orally every day.
Dosage may be increased each day for 3 days.
It is not an officially recognized indication.

Usual Geriatric Dose for Hypertension:

Initial dosage: 2.5 to 5 mg every day, orally.
Doses for maintenance should be increased by 2.5 mg up to 5 mg daily between 1 and 2 week intervals.
Maximum dosage is 40 mg taken orally every day, once

Usual Pediatric Dose for Hypertension:

Children who are older than or equal to 6 years of age:
The initial dose is 0.07 mg/kg taken orally, once per day (the maximum dosage is 5 mg per day).
Dosage for maintenance: Dosage must be adjusted based on the blood pressure response between one and two week intervals.
Max doses: The dosages greater than 0.61 mg/kg or higher than 40 mg haven't been investigated in pediatric patients.
This drug is not advised for patients in the pediatric age group of less than 6 years old or for patients in the pediatric population with a glomerular filtration rate of less than 30 mL/min.

What happens if I miss a dose?

You should take the medication as quickly as you are able, but avoid your missed dose if it's close to the time of the next dose. Don't take two doses at a time.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Be careful not to get up too fast from a lying or sitting position, as you could be dizzy.Don't take sodium supplements or substitutes for salt unless your physician has instructed you to.

Beware of being dehydrated or too hot when exercising in hot weather or simply by not drinking enough fluids. Follow your doctor's advice on the types and amounts of fluids you must consume. In certain situations, drinking too much liquid can be just as harmful as drinking too little.

Side effects of Zestril

See a doctor immediately. If you are experiencing indications for an allergy reaction with Zestril: severe stomach pain, hives, trohivesbreathing, or swelling of your lips, tongue, throat, or face,

Zestril may cause serious side effects. Contact your doctor immediately if you experience:

  • A feeling of lightheadedness, as if you're passing out;
  • High blood potassium: nausea or the feeling of tingling; weakness in the chest; irregular heartbeats; decreased movement;
  • Low white blood cells Low white blood cell counts fever sores in the mouth, skin sores on the sore throat, cough;
  • Kidney issues The kidneys are enlarged, you're not urinating as often, you're tired, or you feel tired,
  • Liver issues include loss of appetite, abdominal pain (upper right shoulder) fatigue, itching, dark urine, a stool that is colored with clay, and jaundice (yellowing of the eyes or skin).

Common Zestril side effects might include:

  • Headache, dizziness;
  • Low blood pressure; cough
  • Chest pain.

This isn't an exhaustive list of all the side effects. Other effects may also be present. Contact your physician to seek medical advice on the effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Lisinopril may affect your kidneys, particularly when you are also taking certain medications for infection, cancer, or osteoporosis.

Discuss with your doctor all other medicines you take, particularly:

  • Diuretic or "water pill" that may boost blood potassium levels, such as spironolactone, triamterene, or amiloride;
  • The NSAIDs (nonsteroidal anti-inflammatory medicines) aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and other NSAIDs;
  • Insulin or diabetes medication;
  • Medicines to avoid organ transplant rejection, such as the medicine temsirolimus, sirolimus sirolimus as well as everolimus as well as
  • Heart or blood pressure medications

This list isn't exhaustive. Other drugs can interact with Zestril, such as prescription and non-prescription drugs, vitamins, and herbal products. Some interactions with drugs are not listed here. are included here.



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