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Generic name: metolazone [me-TOL-a-zone]
Drug class: thiazide diuretics

What is Zaroxolyn?

Zaroxolyn is a diuretic thiazide (water pill) that helps prevent your body from taking in excessive amounts of salt, which could result in water retention.

Zaroxolyn helps treat the problem of liquid retention (oedema) in patients suffering from chronic heart disease or kidney disease, such as the nephrotic syndrome. It is also used to manage the high pressure in blood vessels (hypertension).Zaroxolyn can also be used for reasons not mentioned in this guideline.

Side effects of Zaroxolyn

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as hives, difficulty breathing, or swelling of your lips, face, or tongue.

Zaroxolyn can cause serious adverse reactions. Consult your physician immediately if you suffer from:

  • Chest pain;
  • Beats of your heart, or the sound of fluttering your chest
  • Bleeding or bruising;
  • Feeling lightheaded, like you're about to go into a coma.
  • Liver problems: nausea nausea, stomach pain in the upper part of the stomach, itching, nausea, fatigue, and loss of appetite dark urine; clay-coloured stool; jaundice (yellowing of the eyes or skin);
  • Low potassium: leg cramps, constipation, irregular heartbeats, fluttering of the chest, an increase in thirst or urination you may also experience numbness, tenderness in the muscles, or a feeling of limpness.
  • Low levels of sodium within the body—headaches, confusion in speech, slurred words, severe fatigue, vomiting, lack of coordination, and feeling unstable;
  • Other indications of an imbalance in electrolytes include dry mouth, nausea, vomiting, weakness, fatigue, or lack of energy, muscle pain, a lack of or no urine, or feeling agitated and agitated.
  • Severe skin reaction: an extreme skin reaction that causes fever, sore throat, swelling on your tongue or face, burning in your eyes, and pain in the skin that is followed by an irritated or purple rash that can spread (especially in the face and the upper part of the body) and can cause blisters and peeling.

Common adverse reactions to Zaroxolyn could be:

  • Dizziness, spinning sensation;
  • Drowsiness, tiredness;
  • Depression;
  • Muscles or joint discomfort;
  • Tingling sensation or numbness
  • Nausea and stomach pains, or nausea, loss of appetite,
  • Diarrhea, constipation.

This is not a comprehensive list of all the side effects. Other effects may also be present. Contact your doctor to seek medical advice on the effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Similar or related drugs

amlodipine, lisinopril, metoprolol, losartan, furosemide, hydrochlorothiazide, and spironolactone


Zaroxolyn should not be used when you are not able to urinate or you suffer from a serious liver condition.

Before you take this drug

Zaroxolyn should not be used if you have an allergy to the drug or are suffering from

  • Severe liver disease
  • If you're not able to urinate.

To ensure that zaroxolyn is suitable for you, inform your doctor that you have:

  • The imbalance of electrolytes (such as too low levels of magnesium, potassium, or magnesium in the blood);
  • A heart rhythm disorder
  • An introduction to the sulfa-containing medicines;
  • Liver disease;
  • Kidney disease;
  • Diabetes;
  • Gout
  • Systemic lupus erythematosus.

Utilizing Zaroxolyn during pregnancy can cause adverse reactions in the baby's newborn, like blood cell issues as well as jaundice (yellowing of the eyes or skin). Inform your doctor whether you are expecting or pregnant while taking Zaroxolyn.

Metolazone may be absorbed in breast milk and could cause harm to a nursing infant. Do not breastfeed while taking this medication.Zaroxolyn is not a prescription drug to be used by anyone younger than 18 years of age.

How to take Zaroxolyn?

Read the information on the label that comes with the prescription. Your doctor may change your dosage to ensure you receive the most effective outcomes. Don't take this medication in smaller or larger quantities or for longer periods than prescribed.

Zaroxolyn is typically taken every day.

You might need to cut down on the amount of salt you consume when taking this medication. Make sure you follow the prescriptions of your doctor.While taking Zaroxolyn, there is a chance that you'll need regular blood tests. Your urine and blood may be tested in the event that you've been vomiting or dehydrated.

Zaroxolyn can produce unusual results when you undergo certain tests for medical conditions. Inform any physician who treats you that you're taking this medication.

If you require surgery, be sure to inform your surgeon beforehand that you're taking Zaroxolyn. You might have to stop taking the medicine for a brief period of time.If you're being treated for high blood pressure, you should continue taking this medication even if you are feeling well. High blood pressure can have no signs. It is possible that you will need blood pressure medication throughout your life.The tablets should be stored at room temperature away from heat, light, and moisture.

What happens If I miss a dose?

It is important to take your missed dose as fast as you are able to remember. Be sure to avoid missing doses If it's close to the date for your next dose. Avoid taking any extra medicine in order to replace the dose that was missed.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

The symptoms of an overdose can include dizziness or drowsiness. It can also cause thirst, dry mouth, muscle weakness, feeling lightheaded, and feeling faint.

What should be avoided?

Alcohol consumption with Zaroxolyn could cause side effects.

Avoid becoming too hot or dehydrated during workouts in hot weather or by drinking insufficient fluids. Follow your doctor's advice on the types and amounts of liquids you must consume. In some instances, drinking too much fluid could be as harmful as drinking too little.

Interaction with other drugs

Combining this medication with other medications that can cause you to feel lightheaded may make it worse. Talk to your doctor prior to taking Zaroxolyn along with a narcotic pain medication such as muscle relaxers or medication to treat anxiety or seizures.

Inform your doctor about all the medicines you are currently taking and any new medications you begin or stop taking, particularly:

  • Other blood pressure medications;
  • Digoxin, digitalis;
  • Furosemide or other diuretics (water pills);
  • Insulin or oral diabetes medicine;
  • Lithium;
  • Methenamine;
  • Vitamin D (at high doses);
  • A blood thinner (Warfarin, Coumadin, Jantoven);
  • The nsaids (nonsteroidal anti-inflammatory drugs): ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac (indomethacin), diclofenac, and more;
  • Salicylates—aspirin, Nuprin Backache Caplet, Kaopectate, kneerelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others;
  • Steroid medication includes prednisone and other steroids.

This list isn't exhaustive. Other medications can be incompatible with metolazone, such as prescription and over-the-counter medicines, vitamins, and herbal products. The interactions of all potential drugs are included in this medication guideline.



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