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Generic Name: Ziv-aflibercept ZIV-a-FLIB-er-sept ZIV-aFLIB-er-sept ZIV-a-FLIB-er-sept
Drug class: VEGF/VEGFR inhibitors

What is Zaltrap?

Zaltrap is made of human antibody fragments. It prevents the formation of blood vessels that are currently being formed in tumors that are rapidly growing.Zaltrap is often used in conjunction with other medicines for treating colon cancer that has metastasized to other regions of the body (metastatic).

Zaltrap is typically prescribed in the event that other medications have failed to perform or have stopped working.


It is not recommended to use Zaltrap when you are suffering from extreme bleeding or hypertension that is not controlled (high blood pressure).Before receiving Zaltrap, inform your doctor that you have high blood pressure, open sores or wounds, or have undergone dental surgery or procedures in the past four weeks.If you require surgery, inform the surgeon in advance that you're using this medicine.

Zaltrap could cause serious and even fatal bleeding. Consult your physician anytime if you experience symptoms of bleeding that are unusual, such as bruising easily, bloody stools, a coughing up of blood, or feeling lightheaded or exhausted.If you require dental or surgical work, be sure to inform your dentist or surgeon beforehand that you're using Zaltrap. It is possible that you will be required to stop using the medication at least four weeks prior to your procedure.

Before you take this drug

To ensure that Zaltrap is appropriate for you, consult your doctor if you suffer from:

  • Bleeding issues;
  • Heart issues, high blood pressure;
  • Open sores or skin wounds;
  • Procedures or dental treatments within the last 4 weeks.

Ziv-aflibercept can cause harm to an unborn baby. You might need to have an ultrasound test before commencing this treatment. Make sure you use effective birth control methods to avoid pregnancy while taking this medication for at least one month following the last dose. Inform your doctor if you fall pregnant.

It is possible for pregnancy to be at lower risk if the mother or father is taking this medicine. Women must continue to use birth control to stop pregnancies because this medication could cause harm to a baby who is not yet born.

You shouldn't breastfeed when Zaltrap is being used, at least for a month following the last dose.

Similar/related drugs

Keytruda, Avastin, Capecitabine, fluorouracil, Xeloda, and Betaseron

How to take Zaltrap?

Zaltrap is administered as an infusion to the vein, typically every two weeks. Your healthcare professional will give the injection.The medicine should be administered slowly, and infusions can last for at least one hour.You'll require frequent tests for medical conditions and blood pressure.

Zaltrap could cause issues in the healing of wounds, which can lead to bleeding or an infection. You will need to stop taking Zaltrap for at least 4 weeks prior to having any procedure or dental work. Avoid taking the medication for at least 4 weeks following surgery or until the surgical wound is healed.

Details on dosage

Usual Adult Dose for Colorectal Cancer:

4 mg/kg IV administered over one hour every two weeks Give this medication prior to any other component in the regimen on the day of treatment.
Therapy duration: up until the disease progresses or if there is unacceptable toxicity.

Use: This drug, in combination with 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI), is indicated for patients with metastatic colorectal cancer (mCRC) that is resistant to or has progressed following an oxaliplatin-containing regimen.

What happens If I miss a dose?

Contact your doctor for advice. If you do not make the appointment for the Zaltrap injection,

What happens if I overdose?

Because the medicine is prescribed by a health expert in a medical environment, it is highly unlikely for an overdose to occur.

What should be avoided?

Follow your doctor's advice regarding any limitations on foods, drinks, or activities.

Side effects of Zaltrap

See a doctor immediately. If you show symptoms that indicate an allergy reaction with Zaltrap, such as hives, breathing difficulties, and swelling of your lips, face, and tongue,

Zaltrap could help you get bleeds. Call your doctor or seek medical attention in an emergency in the event of:

  • Easy bleeding, bruising (nose, vagina, mouth), or bleeding that will not stop;
  • Indications of bleeding within your body, such as lightheadedness with brown or pink urine and bloody or tarry stools that cough up blood or vomit that appears like coffee grounds.
  • Indications of bleeding within the brain the weakness is sudden (especially on the opposite facet of the body), with an intense headache and problems with speech or vision.

Contact your doctor immediately. If you are suffering from:

  • Continuous or intense persistent vomiting as well as severe or ongoing vomiting and diarrhea;
  • The appearance of blisters or ulcers inside your mouth, swollen or red gums, difficulty swallowing
  • Any wound that does not heal;
  • Trouble with concentration, headaches, thought problems, loss of vision, seizures;
  • Symptoms of the presence of a blood clot: chest pain, abrupt numbness, or weakness;
  • Indications of perforation (a tear or hole) in the stomach or intestines, such as fever, persistent stomach pain, or changes in your bowel habits;
  • Indications of the presence of a fistula (abnormal passageway) in your lower body rectal pain and vaginal discharge that smells foul, as well as swelling or pain in your stomach area, issues with urination, or stool movements
  • Signs of dehydration feeling very thirsty or hot, not being able to urinate, sweating heavily, or having hot or dried skin;
  • Symptoms of a kidney disorder eye puffiness, swelling of your feet or ankles, weight increase, urine that appears like it's foaming,
  • Lower white blood cell count (fever, oral sores, and skin sores) irritation of the throat, trouble breathing, cough.

Senior adults are more likely to experience severe diarrhea or become dehydrated.

The treatment for cancer may be delayed or completely stopped when you experience certain adverse consequences.

Common Zaltrap adverse effects could include:

  • Raised blood pressure
  • Low white blood cells;
  • Nasal bleeding or bleeding;
  • Stomach pain, diarrhea;
  • Mouth sores and ulcers loss of appetite, loss of weight
  • Headache, fatigue;
  • Hoarse voice,
  • Abnormal liver or kidney test results.

This isn't an exhaustive list of possible side effects, and others could happen. Contact your physician for advice regarding medical adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Other medications can interfere with ziv-aflibercept. This includes prescription and non-prescription medicines, vitamins, and herbal products. Discuss with your physician all your medications currently in use and any medications you begin or stop taking.