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Generical name: sodium oxybateSOE-dee-um-OX” SOE-dee-um OX-i-bateSOE-dee-um”
Dosage form: oral solution, 0.5 g per mL.
The class of drugs: miscellaneous anxiolytics, anxiolytics, hypnotics, and sedatives

What is Xyrem?

Xyrem helps stop the onsets that are a result of cataplexy (episodes of muscle weakness that start abruptly and last for only an indefinite period of time).Xyrem can also be used to treat excessive morning insomnia in children and adults seven years old or older with narcolepsy (a condition that can lead to extreme sleepiness, a sudden and excessive desire to sleep in everyday activities, and cataplexy).Xyrem is part of a class of medicines known as central nervous system depressants. The sodium oxybate medication is used to treat cataplexy and narcolepsy by reducing the activity of the brain.Xyrem can only be purchased through an exclusive program. It is necessary to be registered within the programme and fully understand the potential risks and benefits of this medication.

Side effects of Xyrem

See a doctor immediately in the event that you exhibit symptoms that you are experiencing an allergic reaction to Xyrem, such as asthmatic breathing difficulties and swelling of your lips, face, and tongue.
The sodium oxybate compound can cause serious adverse side effects. Consult your physician right away if you suffer from:

  • Breathing that is weak or shallow; breathing that stops for a short period of time;
  • Sleepwalking;
  • Hallucinations, paranoia, and confusion more tiredness and confusion
  • Depression, anxiety, and other unpleasant or unusual thoughts, feelings of guilt, or low self-esteem;
  • Suicidal ideas or actions.

Common Xyrem side effects could comprise:

  • Sleepwalking;
  • Weight loss and weight loss; appetite loss;
  • Headache;
  • Drowsiness, dizziness;
  • Bedwetting;
  • Nausea, vomiting,

This isn't an exhaustive list of possible side effects, and other side effects could occur. Consult your physician for advice regarding medical adverse effects.It is possible to report any adverse allergic reactions or symptoms to FDA by calling 1-800-FDA-1088.


Sodium oxybate may cause breathing to slow or stop even in regular doses, or if you're also taking stimulant medications.Misuse of Xyrem may result in breathing issues, seizures, loss of consciousness, or even death. Xyrem is available only through a pharmacy that is certified. Don't allow anyone else to take your medicine.The risk of fatal side effects could occur when you mix the medicine with alcohol or other substances that can cause drowsiness or slow respiration.Do not take other medications that cause you to sleep or cause your breathing to slow down. This includes cold or allergy medicines as well as opioid pain medication, sedatives, muscle relaxants, seizures medicine, or medicines to treat anxiety, depression, anxiety, or mental illnesses. Your doctor might need to modify the treatment regimen if it is necessary to take one of these medications.

Before you take this drug.

Don't consume alcohol or other sleeping pills in conjunction with Xyrem.Don't give Xyrem to anyone suffering from an uncommon metabolic condition known as succinicsemialdehyde-dehydrogenase deficiency.

To ensure that this medication is suitable for you, inform your doctor if you've previously had:

  • Respiratory or lung problems;
  • Sleep apnea (breathing stops while sleeping);
  • Depression or suicidal ideas;
  • Mental illness or unusual behaviour (anxiety, agitation, and paranoid hallucinations);
  • An addiction to alcohol or drugs;
  • The heart fails (also known as hypertension);
  • If you're following a diet that has low salt levels,
  • If you take divalproex sodium
  • Kidney or liver illness

It is possible that you will need to adhere to a low-salt diet when you're taking Xyrem, especially if you suffer from elevated blood pressure, kidney problems, or heart problems.Inform your doctor if you are breastfeeding or pregnant.

How to take Xyrem?

Take Xyrem orally according to the prescription of your doctor. Follow all instructions on your prescription label, and review all medication manuals or instructions sheets. It is possible for sodium oxybate to cause breathing to slow or stop even when you are taking regular doses or when you're also taking stimulant medications.Xyrem could be the drug that creates a habit. Intoxication can result in dependence, overdose, or even death. Keep the medication in a place where other people cannot access it. Giving away or selling this medication is against the law.Take Xyrem for at least two hours following a meal or snack. It is crucial to take this medication at the same time every night.

This medication is extremely fast and is best taken when you're lying in bed, ready to go to sleep.Xyrem Oral solutions can be taken during the night, divided into two doses. The first dose is taken before bedtime. The second dosage must be taken between 2 1/2 and 4 hours later. Make both doses before you prepare to go to sleep. The second dose should be placed near your bed so that you can take it in the morning without waking up. Most likely, you'll have to set an alarm for waking up to take your second dosage.Each dose of Xyrem's oral solution should be mixed with two eight ounces (one quarter of a cup) of water within the dosing cups designed for children, which come in the prescription. Both doses should be taken at the same time. Get rid of all oral solutions that were mixed with water but have not been consumed within 24 hours of mixing.There are withdrawal symptoms that you may experience when you stop taking Xyrem immediately. Consult your physician before stopping the medication.Your doctor should monitor your health regularly.Don't store any medicine leftovers. Consult your pharmacist about a take-back programme, or flush the unneeded medicine into the toilet.Place it in a cool, dry place far from heat and moisture.

Details on dosage

Usual Adult Dose for Narcolepsy:

The initial dose is 4.5 grammes orally daily, divided into two equal doses, with the first dose taken at night, followed by the second dose taken between 2.5 and 4 hours later.
The dose can increase by 1.5 grammes (OR 0.75 grammes/dose) at night or orally each week.
Maintenance dose of 6 to 9 grammes per day
Maximum dose: 9 g/day.

Usual Adult Dose for Idiopathic Hypersomnia:

2 times per night:
Initial dosage: 4.5 g orally per day, divided and administered in 2 equal doses
The dose can be increased to 1.5 grammes (or 0.75 grammes per dose) at night, orally. each week.
Dosage for maintenance: 6–9 g/day
Maximum dose: 9 g/day
A nightly routine:
The initial dose is 3 g daily orally, divided and administered in two equal doses.
The dose can be increased to 1.5 grammes (or 0.75 grammes per dose) at night, orally. regularly scheduled intervals during weeks.The maintenance dose ranges from 3 to 6 grammes per day.
Maximum dose: 6 g/day.

Usual Paediatric Dose for Narcolepsy:

7 years old and over:
Amount less than 20 kilogrammes Dosing guidelines for specific doses do not exist.
Between 20 and 30 kg:
Initial dose: up to 2 g every day, split and administered in two equal doses, with the first dose being taken before night followed by the dose taken between 2.5 and 4 hours after.
Dose for maintenance It can increase by one grammes (OR 0.5 grammes/dose) by taking it orally every night for intervals of 1 to 2 weeks, up to 6 grammes per day.
Maximum dose: 6 g/day
30 to 45 kg or less:
Initial dose: up to 3 g daily, divided into two equal doses. The first dose is taken before night, while the other dose is taken between 2.5 and 4 hours later.
Dose for maintenance It is possible to increase by 1 gramme (OR 0.5 mg/dose) every night, orally. 1-to-2-week intervals, up to 7.5 grammes/day.
Maximum dose: 7.5 g/day
More than 45kg:
Initial dose: Up to 4.5 grammes taken orally every day, divided into 2 equal doses. The first dose is taken before bedtime, while the other dose is taken between 2.5 and 4 hours later.
Maintenance dose Dosage for maintenance: The dose can increase by 1.5 grammes (OR 0.75 grammes/dose) in the evening, taken orally at 1- to 2-week intervals, up to 9 grammes per day.
Maximum dose: 9 g/day.

Do I be concerned if I miss a dose?

If you miss the second dose, take this dose off and don't retake a dose until the next day.Take no at least two doses in one go.

What will happen if I take excessively?

Get medical attention immediately, or contact us for help at the Poison Help Line at 1-800-222-1222. A fatal overdose of Xyrem can cause death.Overdose symptoms can be headaches, sweating, vomiting, extreme anxiety, confusion, loss of balance or coordination, a drop in body temperature and coma, blurred vision, trouble breathing, low heart rate muscles weakening, or seizures (convulsions).

What should be avoided?

Avoid drinking or consuming alcohol. Dangerous side effects or even death could happen.Xyrem can cause drowsiness and may affect your thinking or reactions. You should wait at least 6 hours until you're completely awake before you drive or operate machinery, fly an aircraft, or perform anything that requires you to remain awake in a state of alertness. aware.

Interaction with other drugs

Using Xyrem in conjunction with other medications that cause you to become sleepy or cause breathing to slow down could result in dangerous negative side effects or even death. Ask your doctor prior to taking opioids, a sleeping pill, a muscle relaxer, or medication to treat anxiety or seizures. Your doctor might need to alter your treatment plan if you need to take any of these medicines.Other drugs can be incompatible with sodium oxybate, such as prescription and over-the-counter medications, vitamins, and herbal products. Discuss with your doctor all the other medications you take.




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