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What is Vestronidase Alfa?
Vestronidase Alpha contains an enzyme that occurs in the healthy body. A genetic disorder can cause some people to lack this enzyme. Vestronidase alfa is used to replace the missing enzymevestronidase alfa is used to relieve some symptoms associated with mucopolysaccharidosis VII (MYOO-koe-pol-ee-SAK-a-rye-DOE-sis Seven) also referred to as Sly syndrome.
MPS VI is a metabolic disease in which the body does not have the enzymes required to break down certain substances. The substances that build up can cause enlarged organs and abnormal bone structures, as well as changes to facial features. They may also lead to breathing issues, heart problems, or loss of hearing.
Vestronidase beta may help improve the walking abilities of people who have this condition. This medication does not cure MPS VII.This medication guide does not list all possible uses of Vestronidase Alfa.
Side effects of Vestronidase alfa
If you experience any of the following symptoms of an allergy reaction, seek immediate medical attention: difficulty breathing, hives, swelling in your lips, face, throat, or tongue.
A severe allergic reaction can occur shortly after or during the infusion of Vestronidase Alpha. If you experience any of the following symptoms, tell your carer or seek emergency medical attention immediately.
- Feeling like you could pass out even when lying down
- Cool skin or cold sweating
- Feeling short of breath
- Pale skin;
- Blue lips or fingernails.
Vestronidase Alfa may cause the following side effects:
- Diarrhea;
- You may experience swelling in your feet or hands.
- Itching or rash?
- The IV needle may cause swelling and irritation.
There may be other side effects. For medical advice on side effects, call your doctor. Report side effects by calling the FDA at 1-800-FDA-1088.
Warnings
A severe allergic reaction can occur shortly after or during the infusion. If you experience any symptoms of an allergic reaction that are severe, such as difficulty breathing, sweating, blue fingernails or lips, or pale skin, tell your carers right away or seek emergency medical attention.
Before you take this drug
If you've ever:
- A lung condition or breathing problems.
Inform your doctor of any pregnancy or nursing.
How to take Vestronidase Alfa?
Vestronidase is infused into the vein. This injection will be given by a healthcare professional.Vestronidase is given every two weeks. Vestronidase is given very slowly and can last up to 4 hours.You will receive other medication 30–60 minutes prior to each injection to prevent an allergic reaction.When you receive vestronidase, tell your care providers if there is any pain or swelling in the area around the needle.
After receiving the vestronidase, you will be closely monitored for 60 minutes to ensure that there is no allergic reaction.The dose of Vestronidase Alpha is based on your weight. Your dose needs may change if you gain or lose weight.
Vestronidase alfa dosing information
Usual Adult Dose for Mucopolysaccharidosis Type VII:
Infusion IV of 4 mg/kg every two weeks
Use: For the treatment of Mucopolysaccharidosis VII (MPS VII), also known as Sly syndrome.
Usual Paediatric Dose for Mucopolysaccharidosis Type VII:
Infusion IV of 4 mg/kg every two weeks
Use: For the treatment of Mucopolysaccharidosis VII (MPS VII), also known as Sly syndrome.
What happens if I miss the dose?
If you are unable to attend your appointment, call your doctor and ask for further instructions.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention.
Avoid this
If your doctor prescribes any restrictions on foods, drinks, or activities, follow their instructions.
Interaction with other drug
Vestronidase alfa can be affected by other drugs, such as prescription medicines, over-the-counter medications, vitamins, and herbal remedies. Inform your doctor of all the medicines you are currently taking and those that you will begin or stop using.