What is Veklury?
Veklury is a prescribed antiviral medication used for the treatment of COVID-19.Veklury consists of ramdev sivir, which is an analog of nucleotides that works by targeting the SARS-cov-2 viral RNA polymerase, which stops the replication of the virus SARS-cov-2 responsible for COVID-19.
What is Veklury?
Veklury is used in the treatment of COVID-19 among adults and children (who have a minimum age of 28 days and older and weigh seven pounds or more) who are admitted to a hospital or who aren't in a hospital but suffer from moderate to mild COVID-19 and are at a high chance of progressing to severe COVID-19. This could mean death or hospitalisation.It is not clear whether this medication has been proven safe or effective for children who are younger than 28 days of age or with a weight of less than seven pounds (3 kg).
COVID-19 is a virulent infection that is the result of a coronavirus, SARS-cov-2. It is possible to contract COVID-19 by taking in breath-containing droplets that have been exhaled from the person who is infected by COVID-19. It is more likely that this will occur if you are in an intimate relationship with someone suffering from COVID-19.
COVID-19-related illnesses range from mild (including certain cases with no symptoms) to extremely severe, with the possibility of death. Patients with long-term medical conditions such as lung disease, heart disease, or diabetes are more likely to suffer more severe problems and appear to be at a higher risk of being admitted to hospitals by COVID-19.Some symptoms associated with COVID-19 include cough, fever, and breath shortness, which can manifest between 2 and fourteen days following exposure.
Warnings
Veklury is intended for use by people suffering from COVID-19. It is necessary to remain under the supervision of a doctor during treatment with this medication.
Before you take this drug
It is not recommended to take Veklury when you are allergic to the ingredient remdesivir.To ensure that Veklury is safe for you, inform your doctor if you have ever suffered from liver disease.
Pregnancy
Inform your doctor if you are expecting or planning to be pregnant. It isn't known the potential harm this medicine could cause the unborn baby if it is taken in the initial trimester. Inform your doctor right now if you're pregnant or are about to begin to become pregnant.
Pregnancy Registration: There is a pregnancy registry for those who are receiving Veklury during pregnancy. The aim of this registry is to gather details about your health and that of your child. Discuss with your healthcare professional how you can join this registry.
Breastfeeding
Inform your doctor if you are nursing or planning to breastfeed. Veklury may be transferred into the breast milk. Discuss with your healthcare professional the best method to feed your infant.
How to take Veklury?
Veklury is administered as an infusion into the vein. The healthcare professional will give the injection.The doctor will run tests for blood to confirm that there are no problems that hinder you from using Veklury.Veklury should be administered slowly, and the infusion could take between 30 and 120 minutes.If you are admitted to a hospital, you can receive an infusion every day for up to 10 consecutive days.
If you're not in the hospital, you'll receive an infusion every day for three days.You'll need regular blood tests to monitor the function of your liver.You are required to remain under the supervision of a doctor when you receive treatment using Veklury for COVID-19.
Details on dosage
Usual Adult Dose of Veklury for COVID-19:
Loading dose (Day 1): 200 mg IV as a single dose
Dosage for maintenance (from the 2nd day): 100 mg IV at least once per day.
Duration of therapy:
Hospitalized patients who require invasive mechanical ventilation and/or extracorporeal membrane oxygenation (ECMO) for 10 days in total
Hospitalized patients who do not require invasive mechanical ventilation, or ECMO, for more than 5 days could extend to 5 days (for an overall total of 10 days) in the event that there is no improvement in the clinical condition observed.
Non-hospitalized patients: 3 days
Use: To treat the coronavirus infection 2019 (COVID-19) in patients who have positive results from the direct coronavirus severe acute syndrome 2 (SARS-cov-2) tests for virality who:
-Hospitalized, or
Not hospitalized, suffer from moderate or mild COVID-19, and are at a high risk of progression to severe COVID-19, which could lead to death or hospitalization.
Usual Paediatric Dose of Veklury for COVID-19:
Age 12 or over and who weighs at least 40kg:
Loading dose (Day 1): 200 mg IV as a single dose
Maintenance dosage (from day 2): 100 mg IV every day
Aged 28 days or over and weighing 3kg to less than 40kg:
Loading dose (Day 1): 5 mg/kg IV as a single dose
Maintenance dosage (from the 2nd day): 2.5 mg/kg IV every day, once
Duration of therapy:
Patients admitted to hospitals who require the use of invasive mechanical ventilation and/or ECMO for 10 days in total
Patients admitted to hospitals not in need of the use of invasive mechanical ventilation or ECMO for 5 days can be extended 5 days (for an overall total of 10 days) in the event that there is no improvement in clinical condition observed.
Non-hospitalized patients: 3 days
Use: To treat the symptoms of COVID-19 in patients who have positive results from a direct SARS-cov-2 test for viruses who:
-Hospitalized, or
Not hospitalized, suffer from moderate to mild COVID-19, and are at a high chance of developing severe COVID-19, which could lead to hospitalization or even death.
What happens if I miss the dose?
Because you'll be receiving Veklury in a medical setting, you're not likely to be able to miss the dose.
What happens if I overdose?
Because Veklury is administered by a medical professional in the medical environment, you'll be immediately treated when an overdose happens.
What should be avoided?
Follow the instructions of your physician regarding restrictions on drinks, food, or any activity.
Side effects of Veklury
See a doctor immediately. If you are experiencing symptoms that you are experiencing an allergic reaction, Veklury: hives; difficulty breathing or swelling of your lips, face, or tongue.
Certain side effects can be experienced during or following the injection. Contact your physician immediately if you suffer from:
- Extremely headache severe headache, pounding neck or ear;
- Either slow or fast heartbeats that pound
- Wheezing, trouble breathing
- Facial swelling;
- Nausea;
- Fever chills, shivering, or fever;
- Itching, sweating,
- An euphoric feeling, similar to when you're about to pass out.
Common Veklury side effects could include the following:
- Nausea;
- Unusual liver function tests.
This isn't a complete list of possible side effects, and others could happen. Contact your physician for advice regarding medical effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.
Interaction with other drug
Inform your doctor if you also use chloroquine or chloroquine hydroxychloroquine. These other medications may make Velury less effective.
Other medications may be incompatible with remdesivir, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Discuss with your physician the medicines you are currently taking as well as any medications you are about to start or stop taking.
