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Name of the Generic: Urokinase

Name of Brands: Abbokinase

Dosage format: Intravenous

Classification of drugs: Thrombolytics

What is Urokinase?

Urokinase, marketed under Abbokinase, is a thrombolytic medication administered intravenously. Its primary function is to dissolve blood clots that have formed within the blood vessels, particularly in cases of pulmonary embolism.


Before considering the use of Urokinase, patients and healthcare providers must carefully assess the potential risks and benefits of the medication. Several factors should be taken into account:


Patients should inform their healthcare provider of any history of allergic reactions to Urokinase or other medications. This includes allergies to foods, dyes, preservatives, or animals.

Pediatric Use:

The safety and efficacy of Urokinase in pediatric patients have not been established through appropriate studies.

Geriatric Use:

There is no available information regarding the effects of Urokinase in geriatric patients.


There are no sufficient studies to determine infant risks when using Urokinase during breastfeeding. The potential benefits should be weighed against the potential risks before breastfeeding while using this medication.

Before You Take This Medication

It's crucial to consider the medical history and existing conditions before using Urokinase:

Bleeding and Blood Vessel Issues:

Patients with bleeding problems, a history of bleeding, blood vessel problems (such as aneurysms), brain diseases, tumors, uncontrolled high blood pressure, recent strokes, recent brain or spine surgeries or injuries, or recent trauma including CPR should avoid Urokinase.

Blood Clotting Disorders:

Patients with blood clotting disorders, diabetic eye problems, heart diseases, heart infections, recent blood vessel injections, severe kidney or liver disease, recent major surgeries or injuries, or high cholesterol history should use Urokinase with caution due to increased risk of bleeding.

How to Take Urokinase?

Urokinase is administered through intravenous injection by a trained healthcare professional. The medication is delivered via a needle placed into a vein. The healthcare provider will determine the dosage and administration schedule.

Details on Dosage

The dosage of Urokinase will be prescribed by a healthcare professional based on the individual's condition, medical history, and response to treatment. It's essential to adhere to the recommended dosage to achieve optimal results and minimize risks.

What Happens If I Miss a Dose?

As Urokinase is administered under medical supervision, missing a dose is unlikely. However, if a dose is missed, following the healthcare provider's instructions for resuming treatment is essential.

What Happens If I Overdose?

Patients should seek immediate medical attention in case of an overdose or if unusual symptoms occur after Urokinase administration. Overdosing on Urokinase can potentially lead to severe bleeding complications.

What Should be Avoided?

Alcohol and Tobacco:

Consumption of alcohol and tobacco in conjunction with Urokinase should be avoided, as they may interact with the medication and cause adverse effects.

Side Effects of Urokinase

Urokinase can cause a range of side effects, which can vary from mild to severe. Patients should be aware of these potential effects and seek medical attention if any unusual symptoms occur.

Mild Effects

Common mild side effects of Urokinase may include:

  • Bleeding gums

  • Nosebleeds

  • Increased menstrual flow or vaginal bleeding

  • Headache

  • Dizziness

Adverse Effects

In some cases, Urokinase administration can lead to adverse effects that require immediate medical attention:

  • Coughing up blood

  • Difficulty with breathing or swallowing

  • Paralysis

  • Prolonged bleeding from cuts

  • Red or black, tarry stools

  • Shortness of breath

The Interaction Between Other Drugs

Urokinase may interact with certain medications, leading to potential complications. Patients must inform their healthcare provider about all their medications, including prescription and over-the-counter drugs, supplements, and herbal products.

Not Recommended to Use With:

  • Defibrotide

Use With Caution:

  • Acenocoumarol

  • Alteplase, Recombinant

  • Various anticoagulants and thrombolytics

Patients should consult their healthcare provider to ensure that Urokinase is safe to use alongside other medications and to prevent potential interactions that could lead to adverse effects.

By understanding the uses, warnings, proper usage, potential side effects, and interactions of Urokinase (Abbokinase), patients and healthcare providers can make informed decisions about its administration, ensuring effective treatment while minimizing risks. It's essential to closely follow medical guidance and promptly report any concerning symptoms to healthcare professionals for timely intervention and care.




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