Urofollitropin

What is Urofollitropin?

Urofollitropin is the purified version of a hormone known as FSH, which stands for follicle-stimulating hormone (FSH). This hormone is essential in the formation of the follicles (eggs), which are created by the ovaries of women.

Urofollitropin is utilized in conjunction with other drugs to treat infertility among women suffering from FSH deficiency. Urofollitropin can also assist the ovaries in producing more eggs to be used in "in vitro" fertilization.

Urofollitropin is not the sole ingredient that causes ovulation (the production of an egg through the ovaries). It is necessary to take other drugs to induce the process of ovulation.Urofollitropin is also employed for other purposes that are not covered in this guideline for medication.

Side effects of Urofollitropin

See a doctor immediately. If you notice any of the following symptoms that indicate an allergic reaction, symptoms of hives: difficulty breathing or swelling of your lips, face, or tongue.

Women who are taking urofollitropin may develop the condition known as ovarian hyperstimulation syndrome (OHSS), which is most often seen following initial treatment. OHS can be life-threatening. Stop using urofollitropin, avoid sexual contact, and consult your physician immediately when you exhibit any of the following signs of OHSS:

• Stomach pain, bloating;
• Nausea, vomiting, diarrhea;
• Rapid weight loss, particularly on your face and midsection;
• Minimal or no urination little or no urination
• Discomfort when breathing the air, a rapid heart rate while breathing, and feeling breathless (especially when you lie down).

Make sure to contact your doctor anytime if you are experiencing indications of signs of a stroke or a blood clot, for example:

• Suddenly numbness or weakness (especially in one part or the other) and sudden extreme headache and slurred speech. Difficulties with balance or vision;
• Chest pain, a sudden and sudden cough, wheezing or sneezing up blood,
• Pain, swelling, warmth, or redness on either leg or the other

Common adverse effects of urofollitropin could include:

• Stomach cramps, bloating, or stomach pain;
• Headache, general pain;
• Nausea;
• Trouble breathing
• Flashes that flash hot
• Mild pelvic pain and the pain that occurs after an egg is removed to fertilize in vitro.

This list does not encompass all possible adverse reactions; other side effects could occur and should be discussed with your physician or reported directly to the FDA at 1-800-FDA-1088.

Warnings

This medicine is used if you suffer from primary ovarian failure or vaginal bleeding that is abnormal, insufficiently controlled thyroid, adrenal gland problems, ovarian cyst cancer of the breast, the uterus, cancer of the ovary, a pituitary tumor, or infertility that is not due to the absence of ovulation.

Do not take urofollitropin if you are expecting.

Stop taking urofollitropin. Do not engage in sexual relations, and contact your physician immediately when you notice one of these symptoms, such as stomach pain, nausea, bloating, diarrhea, vomiting, rapid weight gain, very little or no urine or discomfort when you breathe, a rapid heart rate, or breathing problems.

Before you take this drug

Urofollitropin should not be used when you have an allergy to urofollitropin and similar medicines (such as follitropin, Lutropin alfa, menotropin, or follitropin) or are suffering from:

• A condition known as primary ovarian failure
• Cancer of the breast, uterus, or ovary
• An untreated, uncontrolled condition of your adrenal or thyroid gland.
• Infertility not caused by ovulation problems;
• Abnormal vaginal bleeding that hasn't been examined by a doctor;
• An ovarian cyst
• An abnormality in your pituitary gland.
• If you are pregnant.

Your doctor will run the tests for blood and pelvic examinations to determine if there are no issues that could hinder you from using the hormone urofollitropin.

The fertility of your male sexual partner is also a must prior to treatment with the hormone urofollitropin.

To ensure that urofollitropin is safe for you, consult your physician if you suffer from:

• Asthma;
• A history of stomach surgery;
• An ovarian cyst, also known as "torsion" (twisting) of your ovary.
• Risk factors that could lead to the development of blood clots (such as smoking, diabetes, heart disease, coronary artery disease, obesity, or having an ancestral background of coronary artery diseases)

The use of urofollitropin could increase the chances of having multiple pregnancies (twins, quadruplets, triplets, etc.). Multiple pregnancies can be risky for the mother as well as the baby. Follow the advice of your physician regarding any medical attention you require while pregnant.

Urofollitropin could also increase the risk of miscarriage, tubal pregnancy, stillbirth, early labor, birth defects, and fever following childbirth if you fall pregnant after having been treated with this medication. Consult your physician if you're worried about these dangers.Urofollitropin could increase your chance of developing uterine cancer. Consult your physician about the risk you are most at risk for. Inform your doctor of any unusual vaginal bleeding promptly.

FDA pregnancy category X While urofollitropin is a good medicine to aid in the process of becoming pregnant, it can cause harm to a newborn baby as well as cause birth defects. Don't use urofollitropin when you are expecting. Tell your doctor immediately if you find yourself pregnant while you are taking treatment.

It isn't known if urofollitropin can be found in the milk of a nursing mother or whether it can harm the baby who is nursing. While taking this medication, breastfeeding should not be attempted.

What is the best way to use urofollitropin?

Follow the directions on the prescription label. Do not take this medicine in smaller or larger amounts or for longer than the recommended time.Urofollitropin is injected into either the skin or muscles. It is possible to be taught how to administer injections at home. Don't inject yourself with this medication when you don't know how to inject the medicine, and dispose of the used needles and syringes.The medicine comes with instructions on safe and effective use. Follow these instructions carefully. Consult your physician or pharmacist for more information.

Urofollitropin is a medicine in powder form that needs to be mixed with liquid (diluent) prior to use. If you're using infusions from home, make sure that you know how to mix and store the medication.Make sure to gently swirl the medicine after mixing. Don't shake the medicine bottle, as you could ruin the medication. Make sure to prepare your dose when you are ready to administer an injection. Avoid using it when the medication is cloudy, changes color, or has particles. Consult your pharmacist about the latest medication.

Following the injection, discard any of the mixed medicine that has not been utilized immediately. Do not keep it for later use.To achieve the best results from fertility treatment, be sure to follow the instructions of your doctor meticulously.

Utilize the disposable needle and syringe for only one time. Be sure to follow any local or state laws regarding disposing of used needles and syringes. Make sure you use puncture-proof "sharps" disposal containers (ask your pharmacist for one and what to do with them). Make sure this container is out of reach of animals and children.

To ensure that the medication is working, you'll require frequent blood tests and ultrasound examinations. It may also be necessary to keep track of your temperature on a daily chart.Storage of unmixed powder at room temperature, away from heat, moisture, and lightyou can also keep the powder in the refrigerator. Don't freeze it.

Infertility is usually treated using a combination of medications. Follow all medications as prescribed by your physician. Review the medication guideline or patient's directions that are included with every medication. Do not alter your dosage or your medication schedule without a physician's approval.

Details on dosage

Usual Adult Dose for Follicle Stimulation:

Induction of ovulation:
Initial dose: 150 international units a day for 5 days, either subcutaneously (SC) or intramuscularly (IM).
Maximum dose: 450 international units per day.
Time of treatment The duration of therapy is 12 days.
Comments:
When pre-ovulatory conditions are met, When pre-ovulatory conditions are met, inject human chorionic gonadotropin (hcg) to stimulate oocyte maturation and ovulation.
If the monitor indicates an increased chance of developing ovarian hyperstimulation (OHSS) on the final day of treatment,
Encourage daily intercourse the day before hcg and continue until ovulation is obvious.
Discourage intercourse if the risk of OHSS is higher.
Aided reproduction:
The initial dose is 225 units of international daily for 5 days, administered subcutaneously.
Menotropin: If given in combination, the combined dose must not exceed 225 international units (150 international units of urofollitropin and 75 units of menotropin from the international market), which is equivalent to 75 international units of urofollitropin as well as 150 units of menotropin in the international market.
Maximum dose: 450 international units per day.
If menotropin is used in conjunction with urofollitropin, the combined dose of menotropin and urofollitropin should not exceed 450 units of international units per day.
Therapy duration Duration of therapy: 12 days
Comments:
Begin on the day of cycle two or three; apply every day until follicular growth is achieved, as measured by ultrasound or analysis of blood estradiol levels.
Continue to treat until sufficient growth of the follicular follicle is apparent, and then give the hcg.
-Refrain from hcg when surveillance suggests a higher chance of OHSS during the final day of treatment.
Uses:
Induction of ovulation in females who previously had pituitary suppression via intramuscular or subcutaneous administration
The development of multiple follicles is part of an assisted reproductive technology (ART) cycle in women who are ovulatory and have previously been treated for pituitary suppression.

What happens if I miss a dose?

Consult your physician for treatment. If you have missed the dose of urofollitropin,

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Follow your doctor's advice regarding any restrictions on your food, drink, or activities.

Interaction with other drugs

Other medications can be incompatible with urofollitropin. This includes medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your health professionals about any medications you are taking currently and all medicines that you decide to stop or modify your use of.