What is Umbralisib?
Umbralisib is a treatment for specific types of lymphoma in adults.Umbralisib can be given when the other chemotherapy treatments failed, had no effect, or were discontinued.
Umbralisib can also be used for other purposes that are not mentioned in this guide.
Side effects of Umbralisib
Contact emergency medical assistance. If you notice symptoms warning signs of an allergic response (hives or breathing difficulties or swelling of your throat or face) or an extreme skin reaction (fever and sore throat, eye burning, irritation or red or purple itching, blisters, and peeling),
Get medical attention when you experience a severe reaction to a drug that affects the body in a variety of ways. Symptoms may include an itch on your skin and fever, swelling of the glands, muscle aches, extreme weakness, unusual bruising, or a discoloration of your eyes or skin.
Umbralisib may cause serious side effects. Consult your physician right away in the event that you experience:
- An extreme skin rash as well as sores or blemishes on your lips or skin;
- Persistent or severe chronic diarrhea or stools containing blood or mucus, or a severe stomachache;
- Issues with the liver, such as stomach symptoms: stomach pain (upper right side), fatigue, itching, the dark color of urine, stools with clay, jaundice (yellowing of the eyes or skin), or
- Low blood cell counts -- fever fatigue, chills, achy mouth sores, skin sores, bruising that is easy, unusual bleeding pale skin, cold feet and hands being lightheaded or breathless.
Common side effects of umbralisib can include:
- Low blood cell count;
- Nausea, vomiting, stomach discomfort, and lack of appetite
- Symptoms of the cold, like nasal stuffiness, sneezing, and sore throats;
- Bone or muscle pain
- Being fatigued; feeling tired;
- Abnormal kidney function tests for abnormal kidney function
This isn't a complete list of possible side effects, and other side effects could be experienced. Contact your physician for advice regarding medical effects. You can report any side effects to the FDA at 1-800-FDA-1088.
Similar or related drugs
Rituximab, Revlimid, Rituxan, Lenalidomide, Ruxience, and Truxima
Warnings
Umbralisib influences the immune system. It is possible to contract infections more frequently and even deadly or life-threatening illnesses. Call your doctor in the event of chills, fever, cough, or any other flu-like symptoms.
Contact emergency medical assistance. Get medical attention immediately if you notice symptoms of a serious skin reaction, like an itch on your skin and blisters, peeling, or sores on your mouth or skin.
Prior to use this drug
Consult your physician if you are suffering from an infection or have previously had:
- An intestinal or stomach disorder;
- Liver issues
- An allergy to aspirin or food dyes with yellow
You might need to undergo an unfavorable pregnancy test prior to commencing this treatment.Men and women who are taking umbralisib must make use of effective birth control in order to stop pregnancies. Umbralisib can harm an unborn child if the mother or father are using the drug.
Continue using birth control for at least one month following your last dose. Contact your doctor immediately if you experience a pregnancy in the presence of both the mother and father while taking umbralisib.
This medicine can impact the fertility (ability to have children) of males. It is nevertheless important to utilize birth control to stop pregnancy, as umbralisib may affect the unborn baby.Don't breastfeed during the course of this medication and at least one month following the last dose.
How to take Umbralisib?
Follow the directions on the prescription label and read the medication guide or instructions sheets. Your doctor may alter the dosage. Follow the medication exactly as prescribed.Eat with food and at the same time throughout the day.Suck the tablet completely, and make sure you don't crush, chew, or break it.
If you have a stomach ache within a few minutes of taking umbralisib, don't take a dose. Make sure you wait until your next scheduled dose time before you can start taking the medicine.Umbralisib can affect the immune system. It is possible to contract infections more frequently, and even severe or fatal infections. Your doctor should check on you regularly.
There are other medications to fight serious infections. Continue to take these medications for the time your physician has prescribed.Do not alter your dosage or stop taking umbralisib without your doctor's guidance.Keep it at room temperature, far from heat and moisture.
Details on dosage
Usual Adult Dose for Lymphoma:
800 mg orally every day
Comments:
Patients must be given prophylaxis against Pneumocystis jirovecii pneumonia (PJP) in the course of treatment.
Consideration should be made to give antiviral prophylactics during treatment in order to prevent the spread of cytomegalovirus (CMV) infectivity, which includes CMV reactivation.
The treatment should continue until the disease progresses or there is unacceptable toxicity.
Uses:
For treatment of patients in adulthood with marginal zone lymphoma (MZL) who have had at least one anti-CD20-based regimen
For the treatment of adults suffering from relapsed or refractory follicular lymphoma (FL) with a history of having had at least three previous treatment regimens
Usual Adult Dose for Follicular Lymphoma:
800 mg orally every day
Comments:
Patients should receive treatment for Pneumocystis Jirovecii pneumonia (PJP) while receiving treatment.
It is recommended to give antivirals prophylactically during treatment in order to prevent the spread of cytomegalovirus (CMV) infectivity, which includes CMV reactivation.
The treatment should continue until there is no more toxicity.
Uses:
for the treatment of adults with relapsed or refractory margin lymphoma of the zone (MZL) patients who've had at least one previous anti-CD20 regimen
For treatment of adults suffering from relapsed or refractory follicular lymphoma (FL) with a history of having had at least three previous treatment regimens
What happens if I miss the dose?
Utilize the medicine as soon as you are able, but avoid your missed dose in case you have been more than twelve hours behind on the dose. Don't use two doses in one go.
What happens if I overdose?
Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.
What should be avoided?
Follow the instructions of your physician regarding any limitations on foods, drinks, or activities.
Interaction with other drugs
Other medications can affect the effects of umbralisib. These include prescription and over-the-counter medicines, vitamins, and herbal products. Discuss with your doctor your current medications as well as any medications you are about to start or stop taking.
