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Name of the generic: Amoxicillin, rifabutin, and omeprazole Rifabutin a-MOX-iSIL-in, oh MEP-ra- and-RIF-aBUE-tin RIF-a-BUE-tin
Drug-class: H. pylori eradication agents

What is Talicia?

Amoxicillin can be described as a penicillin antibiotic. Omeprazole is an inhibitor of the proton pump that reduces stomach acid. Rifabutin can be described as an antibiotic that fights bacteria. Talicia can be described as a mix of medications used to treat Helicobacter pylori (H. pylori) infection in adults. Talicia can also be used for reasons not mentioned in this guideline for medication.

Side effects of Talicia:

Contact emergency medical assistance when you are experiencing symptoms warning signs of an allergic response (hives, breathing problems, and swelling in your throat or face) or an extreme skin reaction (fever and sore throat, burnt eyes, irritation, and red or purple skin itching, blistering, and peeling).

Talicia may cause serious side effects. Contact your doctor immediately in the event that you experience:

  • Intense stomach pains; diarrhoea that is bloody or watery (even when it happens months after the previous dose);
  • A feeling of lightheadedness, as if you're passing out;
  • Easily bleeding, the unusual appearance of red or purple spots beneath your skin
  • Eyes, redness or pain in the eye, or redness, problems with vision Eye pain, vision problems, and spots on your eyes could become more sensitive.
  • Flu-like symptoms: chills, fever, sweating, fatigue, body aches, vomiting, chest pain, cough, feeling weak;
  • Kidney problems: you're urinating more than usual, have a fever, nausea, vomiting, and urine that is bloody and causes confusion, swelling, rapid weight gain, or
  • Lupus-like symptoms include muscle or joint pain, flu-like symptoms, chest pain, and a red or patchy colour of the skin that gets worse in the sun.

Common adverse effects of Talicia could include:

  • Orange, red, or brown discoloration on your skin, sweat, tears, urine, or stool;
  • Indigestion, stomach pain, nausea, vomiting, and diarrhoea;
  • Headache;
  • Colourless urine;
  • Sore throat;
  • The rash
  • Vaginal irritation and discharge

This is not a comprehensive list of all the side effects. Other side effects could occur. Contact your physician for advice regarding medical effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


Inform your doctor if you have ever experienced any allergic reactions to antibiotic medication.

Discuss with your doctor all your medications as well as any new medications you decide to start or stop taking. Numerous drugs can interact, and some medications should not be combined.

Before you start taking this medicine

It is not recommended to use Talicia if you are allergic to amoxicillin (Amoxil, Augmentin), omeprazole (Prilosec), or rifabutin (Mycobutin). A variety of drugs interact and create dangerous side effects. Certain medications are not recommended to be used with Talicia. Your doctor could alter your treatment regimen when you are also using:

  • Delavirdine;
  • Rilpivirine (Juluca); or
  • Voriconazole

Speak to your doctor if you have ever suffered from:

  • An allergic reaction to antibiotics;
  • Lupus;
  • The liver condition;
  • Kidney disease kidney disease

Talicia could cause harm to a baby who is not yet born. Use effective birth control to avoid pregnancy, and inform your doctor if you're pregnant. This medication may reduce the effectiveness of hormonal birth control methods such as contraception injections, implants, skin patches, and vaginal rings. To ensure that you are not pregnant while taking Talicia, use barrier methods of birth control, such as condoms, diaphragm caps, cervical caps, and a contraceptive sponge. This medication can affect fertileness (the ability to have babies) in men. It might not be safe to breastfeed while taking this medication. Talk to your doctor about any risks. Talicia is not a drug that is approved to be used by anyone younger than 18 years of age.

What to take Talicia?

Follow the directions on the prescription label and read the medication guide or instructions sheets. Follow the medication exactly as prescribed. Drink your food with you, and drink a whole glass (8 ounces) of water. Take the capsule in its entirety and don't crush, chew, break, or even open it. For a period of up to 14 days from the last time you used this medication, it can influence the results of specific medical tests, such as the urine test for drug screening. It is possible that you'll get inaccurate results. Inform the lab staff that you take this medication. Inform any physician who treats patients that you're using this medication. Make sure to take this medicine for the prescribed duration, even if symptoms improve quickly. Not taking your medication regularly can increase the chance of developing an infection that cannot be treated with medication. Talicia is not able to treat viral diseases like the flu or a typical cold. Keep this medicine in its original bottle at room temperature,  away from heat and moisture. Make sure the bottle is tightly sealed when not in use.

What happens If I miss a dose?

You should take the medication as quickly as you are able, but avoid any missed doses if you are nearing the time to take the next dose. Don't take two doses at a time.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222. The signs of an overdose are sleepiness as well as blurred vision, nausea, vomiting, dry mouth, sweating, and rapid heartbeats.

What should be avoided?

Do not consume Talicia along with alcohol. The use of antibiotics can trigger diarrhoea, which could be a sign of a new infection. If you are experiencing diarrhoea that's watery or bloody, consult your doctor prior to taking anti-diarrhoea medications. Avoid wearing soft contact lenses. The rifabutin contained in this medication could cause your tears to discolour and may permanently stain contact lenses.

Interaction with other drugs

There are times when it's not recommended to take certain medications simultaneously. Certain drugs may affect the levels in your blood of other medications that you are taking, which can cause more side effects or make the drugs less effective.

Inform your doctor about the medicines you are currently taking. Numerous medications can affect Talicia, specifically:

  • Allopurinol;
  • Clopidogrel;
  • Digoxin;
  • Methotrexate;
  • John's wort;
  • Tacrolimus;
  • An antibiotic (clarithromycin, rifampin, or telithromycin);
  • Antifungal medicine: fluconazole, itraconazole, ketoconazole, posaconazole, and voriconazole;
  • Antiviral medicine to treat HIV/AIDS—fosamprenavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, or tipranavir; or
  • Warfarin, Coumadin, and Jantoven are all blood thinners.

This is not a complete list, and a variety of other medications could influence Talicia. This includes prescription as well as over-the-counter medications, vitamins, and herbal supplements. There are many possible interactions between drugs that are included here.