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Symbyax

Generic name: fluoxetine and olanzapine [floo-OX-eh-teen-and-oh-LAN-za-peen]
The class of drug: psychotherapeutic combinations

What is Symbyax?

Symbyax is a mixture consisting of fluoxetine and olanzapine. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant. Olanzapine can be described as an antipsychotic drug. mSymbyax can be used as a treatment for depression caused by bipolar disorder (manic depression).Symbyax can be used when at least two other medications have been tried without success.

Warnings

It is not recommended to take Symbyax in conjunction with pimozide or thioridazine or if you are taking other medicines that contain fluoxetine or the olanzapine form in a non-combination version. Do not take Symbyax if you've used an MAO inhibitor in the last 14 days, like linezolid and isocarboxazid, as well as methylene blue injection, or phenelzine, rasagiline, and selegiline, as well as tranylcypromine. Symbyax is not a prescription drug for older adults suffering from dementia-related psychosis. Symbyax is not a product that has been approved for use by anyone less than 10 years old. A few young people may have thoughts of suicide after they first start taking antidepressants. Keep an eye on fluctuations in mood and symptoms. Inform your doctor if you notice any changes or worsening symptoms.

Before you take this drug

It is not recommended to take Symbyax when you are also taking pimozide, thioridazine, or other forms of olanzapine or fluoxetine (such as Prozac, Rapiflux, Sarafem, Selfemra, or Zyprexa).

Don't use Symbyax when you've taken an MAO inhibitor within the last 14 days. A risky drug interaction may occur. MAO inhibitors are isocarboxazid, linezolid, Methylene Blue injection, rasagiline, phenelzine, and tranylcypromine. Don't use an MAO inhibitor for more than 5 weeks after stopping Symbyax.

Symbyax could cause an increase in the likelihood of dying in people who suffer from dementia-related psychosis. However, it is not approved for use in this manner.

To ensure that Symbyax is uitable for you, inform your doctor if you suffer from:

  • Alzheimer's disease:
  • Liver disease;
  • Narrow-angle glaucoma;
  • Heart issues;
  • Excessive blood pressure, high blood pressure, or
  • Low white blood cell (WBC) count;
  • A seizure;
  • Bleeding issues;
  • Breast cancer;
  • A stroke, which includes "mini-stroke" or "TIA";
  • Diabetic, high cholesterol, or triglycerides
  • Colon obstruction and serious constipation
  • Electroconvulsive Therapy (ECT);
  • An enlarged prostate or
  • Trouble eating.

Check with your physician if you also take stimulant medicines, opioid medications, herbal products, or medicines to treat mental illness, depression, Parkinson's disease, migraine headaches, serious infections, or for the prevention of vomiting and nausea. These medications can interact with fluoxetine or the olanzapine drug and trigger a severe serotonin-related disorder.

A few young people may have thoughts of suicide while first starting an antidepressant. Your doctor should monitor your progress on a regular basis. Family members or other carers should be on the lookout for changes in your symptoms or mood.

Talk to your doctor about Symbyax when you are expecting. Taking an SSRI antidepressant at the end of your pregnancy can result in serious medical issues for the infant. But you could experience the possibility of relapses in depression when you discontinue using your medication for depression. Inform your doctor immediately if you find yourself pregnant. Do not begin or stop using Symbyax unless on the advice of your doctor. If you're expecting, then your name might be added to the pregnancy registry to monitor the effects of fluoxetine and olanzapine on the child. It might be difficult to become pregnant when you are taking Symbyax.

If you're nursing, consult your physician to determine whether you are experiencing signs of drowsiness, fussiness, problems with feeding, weight loss, or any unusual movement of the baby's muscles. Baby. mSymbyax is not a product that has been approved to be used by anyone younger than 10 years old.

How to take Symbyax?

Use Symbyax exactly as directed by your physician. Follow the instructions on the prescription label and go through all medication guides and instructions. The doctor might modify your dosage.

It is not recommended to stop taking Symbyax abruptly. Follow your doctor's advice on tapering your dose.

Use Symbyax every day at the same time, whether with or without eating.

It could take up to four weeks before symptoms improve. Use the medication exactly according to the directions, and inform your doctor if you feel your symptoms don't improve.

Storage: Store Symbyax in a cool, dry place away from heat and moisture.

Details on dosage

Usual Adult Dose of Symbyax for Depression:

Initial Dose: 25 mg of fluoxetine and 6 mg of olanzapine, orally, at least every day, once
Dosage for maintenance Adjust the dose as is clinically required within an interval of:
Fluoxetine: 25–50 mg taken orally every day.
Olanzapine: 3–12 mg once orally every day.
Maximum dose: 50 mg of olanzapine orally every day.
Duration It is widely accepted that treatment-resistant depression, or Bipolar I disorder, which includes the depressive episodes that are associated with Bipolar I disorder, can be described as a chronic disease that requires ongoing treatment.

Use: A quick treatment for depression resistant to treatment and depressive episodes related to bipolar I disorder

Usual Adult Dose for Bipolar Disorder:

Initial Dose: 25 mg of fluoxetine and 6 mg of olanzapine, orally, at least every day, once
Dosage for maintenance: adjust as needed within the interval of:
The dosage range is 25 to 50 mg taken orally every day.
-Olanzapine: 3–12 mg taken orally, once per day.
Maximum dose: 50 mg of olanzapine (12 mg orally every day).
Duration It is widely accepted that treatment-resistant depression, or Bipolar I disorders, as well as the depressive episodes that are associated with Bipolar I disorder, can be described as chronic diseases needing ongoing treatment.

Treatment: A short-term treatment for depression that is resistant to treatment and depressive episodes related to Bipolar I Disorder

Usual Geriatric Dose for Depression:

Initial Dose: fluoxetine 25 mg/olanzapine 3 mg up to fluoxetine 25 mg/olanzapine 6 mg orally, once per day.
The dose for maintenance should be adjusted with care according to the clinical need, but within the range of
The dosage range is 25 to 50 mg taken orally every day.
"Olanzapine": 6–12 mg once orally every day
Maximum dose: 50 mg of olanzapine (12 mg orally every day).
Duration The general consensus is that treatment-resistant depression, or Bipolar I disorders, which include the depressive episodes that accompany Bipolar I disorder, are both chronic diseases that require ongoing treatment.

Treatment: A short-term treatment for depression that is resistant to treatment and depression episodes that are related to bipolar I disorder

Usual Geriatric Dose for Bipolar Disorder:

Initial Dose: fluoxetine 25 mg-olanzapine 3 mg-olanzapine to fluoxetine 25 mg-olanzapine 6, mg orally twice per day.
Dosage maintenance be adjusted with care when clinically required to stay within the range of
Fluoxetine: 25–50 mg taken orally every day.
"Olanzapine": 6 to 12 mg once orally every day.
Maximum dose: 50 mg of olanzapine, 12 mg taken orally every day.
Duration It is widely accepted that treatment-resistant depression, or Bipolar I disorders, as well as the depressive episodes that are associated with Bipolar I disorder, can be described as chronic conditions needing ongoing treatment.

Use: A quick treatment for depression resistant to treatment as well as depression-related episodes that are associated with bipolar I disorder

Usual Paediatric Dose for Depression:

Between 10 and 17 years of age:
Initial Dose: 25 mg of fluoxetine and 3 mg of olanzapine, orally, three times every day.
Dosage for maintenance Adjust the dose as is clinically required to be within an interval of:
Fluoxetine: 25–50 mg taken orally daily.
Olanzapine: 6–12 mg daily orally
Maximum dose: 50 mg of olanzapine, 12 mg taken orally daily.
Duration The general consensus is that bipolar I disorder, including the depressive episodes that are associated with it, is an ongoing illness that requires continuous treatment.

Treatment: A quick treatment for depression-related episodes that are associated with bipolar I disorder

Usual Paediatric Dose for Bipolar Disorder:

Between 10 and 17 years of age:
Initial Dose: Olanzapine 25 mg, Fluoxetine 3 mg, taken orally, once every day.
Dosage for maintenance: Adjust the dose as clinically required to be within the interval of:
Fluoxetine: 25–50 mg taken orally daily.
Olanzapine: 6–12 mg taken orally daily.
Maximum dose: 50 mg of olanzapine, 12 mg taken orally every day.
Duration It is widely accepted that bipolar I disorder, including the depressive episodes that accompany it, is an ongoing illness that requires continuous treatment.

Treatment: A quick treatment for depression-related episodes that are associated with bipolar I disorder

What happens If miss a dose?

You should take the medication as quickly as you can. However, avoid any missed doses if it's nearing the time to take the next dose. Don't take two doses at once.

What happens If I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided?

Alcohol consumption can cause an increase in certain adverse effects associated with Symbyax. Avoid operating machinery or driving until you are aware of how Symbyax can affect your body. Be careful not to get up too quickly from a seated or lying position, as you may experience dizziness. The feeling of dizziness or excessive drowsiness may result in fractures, falls, or other injuries.

Side effects of Symbyax:

Seek medical attention immediately. If you show symptoms that you are experiencing an allergic reaction to Symbyax, such as a skin rash or itching, breathing problems, and swelling of your lips, face, or tongue, Get medical attention. If you experience symptoms of a severe reaction to a drug that affects the body's many organs, Signs could include an itch or fever, swelling of the glands, flu-like symptoms, unusual bruising, and jaundice (yellowing of the eyes or skin).

Long-term usage of Symbyax can trigger a severe disorder of movement that may not be reversible, especially in women or older people. Inform your doctor immediately if you experience uncontrollable muscle movement in your tongue, lips, eyes, face, or legs.

If you notice any new or more severe symptoms to your physician, for example, mood or behaviour changes, anxiety, panic attacks, and trouble sleeping, or if you experience being uncontrollably angry, irritable, and aggressive, active, restless (mentally as well as physically), or more depressed, or if you are thinking about suicide or harming yourself,

See your doctor right away. If you suffer from:

  • Bleeding or bruising that is unusual;
  • Vision change;
  • Heartbeats that are fast or rapid, feeling like your chest is fluttering, as well as breathlessness and dizziness that is sudden (like you're about to pass out);
  • Signs of dehydration Feeling very thirsty or hot, unable to urinate, sweating excessively, or having hot or sweaty skin;
  • Extreme nervous system reactions Very rigid (rigid) muscles and sweating; high fever and confusion; rapid or irregular heartbeats; or the sensation that you may faint;
  • Blood sugar levels are high. more thirst, more frequent urination, food cravings,  the smell of fruity breath, as well as confusion and nausea;
  • lower sodium Low sodium level headache or confused speech; confusion; extreme weakening; vomiting; lack of coordination in the legs; or
  • lower white blood cell count, chills, fever, skin sores, mouth open sores, irritation of the throat, cough, and trouble breathing.

 

Get immediate medical attention. If you experience signs associated with serotonin syndrome, for example, hallucinations, agitation, sweating, chills, shivering, rapid heart rate, stiffness of muscles and twitching, loss of coordination, nausea, vomiting, or diarrhoea,

The most common Symbyax-related side effect is:

  • Blurred vision, drowsiness, dry mouth;
  • Increased appetite, weight gain
  • Difficult to concentrate, tired;
  • Swelling of your feet or hands
  • Tremor; or
  • Abnormal test of cholesterol or liver function.

This isn't a complete list of possible side effects, and other side effects could occur. Consult your physician to seek medical advice on adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Symbyax may cause serious heart conditions. The risk of developing heart problems is higher if you take certain other medications for asthma, heart conditions, high blood pressure, mental illness, depression, malaria, cancer, or HIV.

Making use of Symbyax together with other medications that cause you to feel drowsy or cause your breathing to slow can make these effects worse. Talk to your doctor prior to using opioids, sleeping pills, muscle relaxers, cold or allergy medicine, or medicines that treat anxiety and seizures.

Talk to your physician prior to using a nonsteroidal anti-inflammatory medication (NSAID) like ibuprofen, aspirin (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, and meloxicam, among others. Utilising an NSAID along with Symbyax can cause bleeding or bruises easily.

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