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Sustol (injection)

Generic name: granisetron (injection) [gra-NIS-e-tron]
The brand name is Sustol.

Drug class: 5HT3 receptor antagonists

What is Sustol?

Sustol stops the actions of body chemicals that trigger vomiting. Sustol can be used to treat nausea and vomiting that could be caused by medicines used to treat cancer (chemotherapy) or after taking the drug. Sustol may be combined with other anti-nausea medicines. Sustol can also be employed for other purposes that are not covered in this guideline.

Side effects of Sustol

See a doctor immediately. Get medical attention immediately if you notice symptoms that are warning signs of an allergic response, such as difficulty breathing, hives, and swelling of your lips, face, and tongue.

Certain side effects can be experienced for up to two weeks after being given Sustol.

Sustol could cause severe adverse effects. Consult your doctor immediately in the event of:

  • Swelling, pain, bleeding, and skin changes an unsettling lump in the area where the injection was administered;
  • Extremely constipation;
  • Headache that causes chest pain, extreme dizziness, fainting, rapid, or pounding heartbeats;
  • Serotonin levels that are elevated within the body cause anxiety High fever, fast heart rate excessively active reflexes, nausea diarrhea, lack of coordination, and fainting.

Common adverse effects of Sustol could be:

  • Headache;
  • Stomach pain, constipation;
  • Fever or
  • Atypical liver test results

This is not a comprehensive list of possible side effects, and other side effects could occur. Consult your physician for advice regarding medical adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Warnings

Before you start treatment with Sustol, be sure to inform the doctor of all of your medical issues, particularly heart issues. Also, ensure that your doctor is aware of every medication you're taking.

Before taking this medication

It is not recommended to take Sustol if you have an allergy to it. To be sure Sustol is suitable for you, inform your doctor if:

  • Kidney disease;
  • Coronary disease;
  • A heart rhythm disorder
  • An individual or family experience of the syndrome of long qt;
  • An electrolyte imbalance (such as low levels of magnesium, potassium, or magnesium in the blood);
  • If you've undergone an operation for your stomach or your intestinal tract, for example,
  • If you're allergic to medications such as sustol (dolasetron, ondansetron, aloxi, anzemet, lotronex, zofran, or others).

It isn't known if Sustol could harm an unborn baby. Consult your physician if you are expecting. It is unclear if it is known if granisetron is absorbed into breast milk or whether it can harm nursing babies. Inform your doctor if you are breastfeeding.

How to take Sustol?

Sustol can be injected under the skin or into a vein via an IV. A healthcare professional will administer this injection. Sustol is typically administered at least 30 minutes prior to the beginning of chemotherapy. If used to stop nausea and vomiting that can be caused by surgery, you'll get Sustol prior to or following the surgery. Your physician will decide the frequency of treatment with Sustol and for how long.

What happens if I miss the dose?

Because you'll receive Sustol in a medical setting, you will not be able to miss the dosage.

What happens if I overdose?

Because Sustol is prescribed by a health specialist in a medical setting, it is highly unlikely for an overdose to occur.

What should be avoided?

Follow the instructions of your physician regarding any restrictions on your food, drink, or activities.

Interaction with other drugs

Sustol may cause a serious heart issue, particularly in the event that you are taking certain medications in conjunction, such as antidepressants, antibiotics, heart rhythm medicines, antipsychotic medications, and other medicines to treat malaria, cancer, HIV, or AIDS.

Sustol intake while taking other medications can result in excessive levels of serotonin accumulating within your body. This is an issue known as "serotonin syndrome," which could be fatal. Consult your physician if you are also taking:

  • Lithium;
  • Ritonavir;
  • John's wort;
  • An antidepressant
  • Migraine medication;
  • A drug called a narcotic (opioid) medication, a muscle relaxer, or
  • Other medications to treat nausea

This list isn't complete. Other medications may be incompatible with granisetron, such as prescription and over-the-counter medicines, vitamins, and herbal products. Not all interactions are included in this guideline. Inform your doctor of any medications you take as well as the medicines you begin or stop taking while you're taking Granisetron.