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Name of the generic: Sugammadex [ soo-GAM-ma-dex ]
Brand name: Bridion
Dosage in the form of an intravenous solution (100 mg/mL)
Drug class: Miscellaneous central nervous system agents

What is Sugammadex?

Sugammadex is a remedy for the negative effects of certain drugs that are administered during surgery to relax your muscles. Sugammadex is administered after surgery to assist in the restoration of the function of muscles that had been restricted during surgery by other medications. Sugammadex can also be used for other purposes not covered in this medication guide.

Side effects of Sugammadex

See a doctor immediately if you are experiencing symptoms that indicate an allergic reaction, such as hives, skin eruptions, and redness, difficulty breathing or swelling of your lips, face, or tongue.

Inform your caregivers immediately in the event that you are suffering from:

  • Flushing (warmth, redness, warmth, or tingly sensation);
  • Itching;
  • Eyes, itching, or discomfort;
  • Extreme weakness, or weak or slow breathing.

The most common side effects of sugammadex are:

  • Heartbeats that are slow
  • Nausea, vomiting;
  • Pain;
  • Headache Or
  • A feeling of lightheadedness, as if you're about to pass out.

This isn't a complete list of all the side effects. Other side effects could occur. Contact your doctor to seek medical advice on the effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Similar or related drugs

pyridostigmine, Mestinon, neostigmine, Bridion, edrophonium, Prevduo, glycopyrrolate/neostigmine


Before receiving sugammadex, inform your doctor of all medical conditions or allergies, as well as all medications you take. Also, ensure that your doctor knows that you are breastfeeding or pregnant.

Before taking this medication, you must consult your physician.

Sugammadex is not a good option when you are allergic to it. To be sure sugammadex is suitable for you, inform your doctor if you suffer from:

  • renal disease (or if you're taking dialysis);
  • Liver disease;
  • A bleeding or blood clotting disorder, such as haemophilia
  • lower levels of platelets in the blood low levels of platelets in the blood
  • A breathing disorder.

It isn't known if sugammadex could cause harm to a baby who is not yet born. Consult your physician if you are expecting.

Sugammadex can make hormonal contraceptives less efficient. At least seven days after receiving sugammadex, you should use a non-hormonal backup birth control (condom or diaphragm containing the spermicide) to avoid pregnancy. Contraceptives containing hormones (birth control pills,injections,implant sjections implant, patches for the skin, as well as vaginal rings) are not always enough to avoid pregnancy at this point.

It's not clear if sugammadex is absorbed into breast milk or if it is harmful to the nursing infant. Consult your physician if you are breastfeeding a child.

How to take sugammadex?

Sugammadex is administered into a vein via an IV. A doctor will administer this medication by injection.

Your blood pressure, breathing, kidney function, oxygen levels, and other vital indicators will be closely monitored during the time you take Sugammadex.

Details on dosage

Usual Adult Dose for Reversal of Nondepolarizing Muscle Relaxants:

Reversal of routine (rocuronium or vecuronium):
4 mg/kg IV once when the recovery has reached 1 to 2 posttetanic counts (PTC) and there is no Twitch response to train-of-four (TOF) stimulation.
2 mg/kg IV once when the patient has recovered and regained second twitch responses to TOF stimulation.

Instant reversal (rocuronium):
16 mg/kg once intravenously

Dosing is based on body weight. The recommended dosage does not depend on the regimen of anesthetic.
The degree of satisfaction with recovery must be assessed through skeletal muscle tone tests and respiratory tests, as well as the response to stimulation of the peripheral nerve.
The effectiveness of the dose of 16 mg/kg in the wake of vecuronium-induced neuromuscular blockade has not yet been studied.

Applications: To reverse various degrees of neuromuscular blockade that are triggered by rocuronium bromide in patients who are undergoing surgery.

What happens If I miss a dose?

Because sugammadex is only a single dose, it doesn't require a daily dosage schedule.

What happens if I overdose?

Because sugammadex is administered by a medical specialist in a medical setting, there is no risk of overdose.

What should be avoided?

Follow the doctor's advice regarding any restrictions on your food, drink, or activities.

Interaction with other drugs

Discuss with your physician the current medications you are taking, particularly:

  • Toremifene;
  • A blood thinner -- warfarin (coumadin, jantoven);
  • Hormonal birth control—birth control pills, injections, implants, skin patches, vaginal rings, or
  • Medication to stop blood clots: dabigatran (pradaxa), rivaroxaban (xarelto), and many more.

Other medications may be incompatible with sugammadex, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Be sure to inform your health professionals about any medications you take currently and all medicines you stop or start taking.