The Web Health


Sudafed PE Sinus Headache

Generic name: acetaminophen and phenylephrine [a-SEET-a-MIN-oh-fen-and-FEN-il-EFF-rin]
Brand names: Acetaminophen Congestion and Pain, Alka-Seltzer Plus Cold and Sinus, Excedrin Sinus Headache, Mygrex, Sudafed PE Pressure Plus Pain, etc. display the 20 different brands.
Classification of drugs: upper respiratory combinations

What is Sudafed PE Sinus Headache?

Acetaminophen is an anti-inflammatory and a fever-reducer. Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Blood vessels that are dilapidated can lead to nasal congestion (a stuffy nose). Sudafed PE Sinus Headache is a combination medication used to treat headaches, body aches, fever, congestion of the nose, and sinus congestion due to allergies, the common cold, or the flu.

Side effects of Sudafed PE sinus headache

See a doctor immediately. If you experience one of the following symptoms of an allergic reaction: hives; trouble breathing; and swelling of your lips, face, and tongue. In rare instances, acetaminophen could trigger an extreme skin reaction that could result in death. This could occur even if you've used acetaminophen previously and did not experience any reaction. Stop taking Sudafed PE for sinus headaches. Call your doctor immediately when you notice the appearance of a rash or skin redness that grows and causes peeling and blistering. If you have this type of reaction, then you should not take any medication that contains acetaminophen. The medicine could cause serious adverse effects. Stop taking the medication and contact your doctor immediately. If you suffer from:

  • Rapid, slow, or unbalanced heart rate;
  • Confusion, hallucinations;
  • Tremor, seizure (convulsions);
  • Minimal or no urination
  • Nausea, stomach pain, the sensation of itching, and a loss of appetite dark urine, stools with a clay-colored color, jaundice (yellowing of the eyes or skin), or
  • Extreme hypertension (severe headache, blurred vision, a buzzing in your ear, anxiety, confusion, chest pain, shortness of breath, seizures).

Common adverse results of Sudafed PE sinus headache can include:

  • Dizziness, weakness;
  • Mild headache;
  • Mild nausea, diarrhea, or upset stomach;
  • Nose that is runny;
  • Feeling anxious or restless. feeling anxious, restless, or nervous
  • Sleep problems (insomnia).

This is not an exhaustive list of side effects. Other side effects could occur. Consult your physician for advice on medical adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Related drugs

epinephrine topical, pseudoephedrine, phenylephrine nasal, mometasone nasal, sodium chloride nasal, Afrin, and Nasonex 24HR Allergy


Do not take this medicine. If you've had an MAO inhibitor within the last 14 days. A potentially dangerous drug interaction could occur. MAO inhibitors comprise isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Don't take any more than recommended. Acetaminophen overdose could damage your liver and result in death. Call your doctor immediately if you experience nausea, discomfort in your stomach area, itching, lack of appetite, dark urine, stools with a clay-colored color, or jaundice (yellowing of your eyes or skin).

In rare instances, acetaminophen can cause an extremely severe skin reaction. Take a break from this medication and consult your physician right away in the event of the appearance of a rash or skin redness that can cause blisters and peeling.

Before you take this drug

It is not recommended to use Sudafed PE for sinus headaches in the event that you're allergic to acetaminophen (Tylenol) or phenylephrine.

Do not take this medicine if you have previously used an MAO inhibitor within the past 14 days. A potentially dangerous drug interaction could occur. MAO inhibitors comprise isocarboxazid, rasagiline, linezolid, phenelzine, selegiline, tranylcypromine, and selegiline.

Consult a pharmacist or doctor about whether it is safe to take this medication if you suffer from any other medical condition, particularly:

  • Liver disease, cirrhosis, or an underlying background of alcoholism, or if you consume more than 3 alcoholic drinks daily;
  • High blood pressure, heart disease, coronary artery disease;
  • Thyroid hyperactive;
  • Pheochromocytoma (an adrenal gland tumor) or
  • If you are taking an antidepressant.

It isn't known if Sudafed PE Sinus Headache can cause harm to a newborn baby. Do not take cold or cough medicines without consulting your doctor when you are pregnant.

Acetaminophen and phenylephrine can be absorbed into breast milk and harm the baby who is nursing. Decongestants can also affect the production of breast milk. Do not take cold or cough medicine without consulting a physician if you're expecting. Always consult with a physician before giving a cold or cough medicine to children. Death can occur due to the use of cough and cold medicine when children are very young.

How to take Sudafed PE sinus headache?

Follow the directions on the label or as directed by your physician. Do not take longer than recommended. The typical cold medicine is used for a brief period of time until symptoms are gone. Take no more than is recommended. A high dose of acetaminophen could damage your liver or cause death.

Dissolve one packet of powder in at least 4 ounces of water. Mix the mixture well and drink it all immediately. Drop the tablets into the glass of water (at least 4 ounces or one-half cup). Mix the mixture well and drink it all immediately.

Stop taking the medicine and contact your doctor if you have a fever after three days of use, if you are still experiencing discomfort after seven days (or five days in the case of children), if your symptoms worsen, if you notice an underlying skin rash or headache that continues to recur, or if you notice any swelling or redness. If you are in need of surgery or medical tests, inform your doctor or surgeon if you have taken this medication within the last few days. Keep at room temperature, away from heat and moisture.

What happens if I miss the dose?

As Sudafed PE for sinus headache can be taken as needed, you might not be on a regular dosing schedule. If you take the medicine regularly, you should take the dose you missed as soon as you remember. Do not take your missed dose if you are close to when your next dose is due. Don't take extra medicine to make up for the missed dose.

What happens if I overdose?

Seek medical attention in an emergency situation or contact the Poison Helpline at 1-800-222-1222. Acetaminophen in excess can be fatal.

The first symptoms of an acetaminophen-related overdose include a loss of appetite, nausea, vomiting, stomach pain, sweating, and a feeling of weakness or confusion. The symptoms that follow may include discomfort in your stomach, dark urine, and the appearance of yellowing on your skin or the whites of your eyes.

What should be avoided?

This medication can affect your ability to think and react. Be cautious when driving or doing any activity that requires you to stay aware.

Consult a physician or pharmacist before taking any cold, allergy, pain, or sleep medicine. Acetaminophen (sometimes abbreviated as APAP) is found in a variety of combination medicines. Combining certain medicines can result in excessive amounts of acetaminophen, which could result in an overdose that is fatal. Check the label to find out if the medicine has acetaminophen in it or APAP. Do not drink alcohol. It could increase the risk of liver damage when taking acetaminophen.

Interaction with other drugs

Other drugs can interact with phenylephrine or acetaminophen, such as prescription and over-the-counter medications, vitamins, and herbal products. Inform your healthcare providers about all medications you are currently taking and any medications you begin or stop taking.




Prescription only

Pregnancy & Lactation

CSA Schedule*
Related Drugs
Related Stories