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What is Strensiq?
Strensiq is an enzyme replacement medicine that is used to treat hypophosphatasia (HYE-poe-FOS-fa-TAY-zha).The rare and elusive genetic condition that results in an insufficient amount of an enzyme that aids your body in processing calcium as well as phosphorus This can cause the growth, development, and abnormality of teeth and bones, which can result in fragile or soft bones as well as growth issues and tooth loss.
Warnings
Follow the instructions on the label of your medication and the packaging. Inform your health care providers about your medical issues, allergies, and any medications you take.
Before you take this drug
You shouldn't use Strensiq if you have an allergy to alpha-asfotase.Before you start using Strensiq, consult your doctor about any of your allergies or medical conditions.
Your name might be recorded in a patient's registry when you're using Strensiq. This will allow you to monitor and assess any negative long-term consequences of this medication.It isn't known if Strensiq could harm an unborn baby. Inform your doctor if you are expecting or planning to be pregnant.It is unclear if asfotase is present in the milk of a nursing baby or whether it can harm the infant. Consult your physician if you are breastfeeding a child.
How to take Strensiq?
Strensiq is typically prescribed three to six times per week. Follow the instructions of your doctor for dosage with care. Don't use this medication in greater or lesser quantities or for longer periods than suggested.
Follow all instructions on the label of your prescription and also read the medication guides or instruction sheets. Make sure you use the medicine precisely as directed.Strensiq is injected beneath the skin. The healthcare professional may instruct you on how to use the drug on your own.Be sure to read and adhere to any instructions for use that come along with your medicine. Talk to your pharmacist or doctor to clarify any instructions.
Make an injection only once you're ready to administer it. Don't use any medicine that changes color or has particles. Consult your pharmacist about the latest medication.It is possible to require two vials and two separate syringes in order to get one dose of this medication. Follow the dosing instructions given by your doctor with care.Your physician will tell you the best place on your body for you to administer Strensiq. You should use a different spot every time you administer an injection. Don't inject the same area twice in one row.Strensiq dosages are based on weight (especially in teenagers and children). Your dose needs may change if you gain or lose weight.
You might require regular eye exams.This medication can alter the results of some medical tests. Be sure to inform any doctor treating patients that you're using Strensiq.Place this medicine in the original container in a refrigerator away from sunlight. Do not shake or freeze this medication.
It is possible to take the medication from the refrigerator and allow it to be at room temperature prior to injecting the dose. Don't leave the medicine in your refrigerator for more than an hour.The contents of each bottle are intended for one usage only. Dispose of it after one use, regardless of whether there's still some medicine in it.Make use of a needle and syringe just once, and then put them in a puncture-proof "sharps" container. Make sure you follow local or state laws regarding how to dispose of the container. Keep it out of the reach of pets and children.
Details on dosage
Usual Adult Dose of Strensiq for Hypophosphatasia:
Usual dosage 2 mg/kg subcutaneously three times per week or 1 mg/kg subcutaneously on six occasions each week.
Maximum dose: 9 mg/kg per week
Comments:
For patients with perinatal or infantile-onset hypophosphatasia (HPP), an increase to 3 mg/kg three times per week may be necessary for insufficient efficacy (e.g., no improvement in respiratory status, growth, or radiographic findings).
Injection site reactions can affect the tolerance of the six-times-a-week dosage regimens.
Use: To treat patients with perinatal, infantile, or young-onset HPP.
Usual Pediatric Dose of Strensiq for Hypophosphatasia:
Usual dosage 2 mg/kg subcutaneously 3 times a week or 1 mg/kg subcutaneously on 6 occasions each week.
Maximum dose: 9 mg/kg per week
Comments:
For patients with perinatal or infantile-onset hypophosphatasia (HPP), an increase to 3 mg/kg three times per week may be necessary for insufficient efficacy (e.g., no improvement in respiratory status, growth, or radiographic findings).
Injection site reactions can affect the tolerance of the six-times-a week dosage regimens.
Use: To treat patients suffering from perinatal or infantile HPP as well as young-onset HPP.
What happens If I miss a dose?
Consult your physician for the appropriate treatment when you have missed a dose of Strensiq.
What happens if I overdose?
Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.
What should be avoided?
Do not inject this medication into areas of the skin that are swollen or red.
Side effects of Strensiq
Seek medical attention immediately. If you notice symptoms of an allergic reaction, Strensiq symptoms include hives, nausea, dizziness, and vomiting; difficulty breathing; a choking feeling; or swelling of your lips, face, or tongue.
See your doctor right away. If you suffer from:
- Vision change;
- Urinating more or less frequently than normal
- Uncomfortable or difficult to urinate;
- Pink, red, or brown urine
- Intense pain in your back or lower back.
Common Strensiq side effects are:
- Itching, pain, bruises, redness, pitting, hardening, or other skin conditions in the area where the medication was injected
This is not a comprehensive list of all the side effects. Others could happen. Contact your physician for advice regarding medical effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.
Interaction with other drugs
Other drugs can be incompatible with asfotase, which includes prescription and over-the-counter medications, vitamins, and herbal products. Inform your physician about all the medicines you are currently taking as well as any medications you are about to start or stop taking.