The Web Health

Subscribe

Stimate (nasal)

Generic name: desmopressin (nasal) [DEZ-mo-press-in]

Brand names: DDAVP nasal, DDAVP nasal nasal, Noctiva nasal, Stimate nasal
Drug class: antidiuretic hormones

In the U.S., Stimate has been discontinued. There may be equivalents if generic versions have been approved by the FDA.

What is Stimate nasal?

Stimate, a synthetic form of the hormone found in the pituitary, is manufactured by humans. This hormone regulates water use, blood pressure, and kidney function. Stimate can be used to treat central cranial diabetes insipidus and increased thirst or urination due to head surgery or trauma.

Stimate medication is used to treat bleeding in patients with hemophilia A and von Willebrand disease type I. Noctiva can be used to treat excessive nighttime urination among adults aged 50 and older. Noctiva is not recommended for treating night-time bedwetting. This medication guide does not list all possible uses of Stimate.

Side effects of Stimate nasal

If you experience any of the following signs and symptoms of an allergic reaction: difficulty breathing, hives, facial, throat or lips swelling and difficulty swallowing - seek medical assistance immediately!

Stimate can cause serious side effects. If you experience:

  • Signs of low sodium: headache, confusion, hallucinations, muscle pain, weakness, or drowsiness. Also, nausea, irritability, restlessness, or feeling restless are all possible symptoms.
  • Rapid weight gain and swelling of the ankles or feet;
  • A seizure (convulsions);
  • Nasal problems: runny or stuffy nasal congestion.

Children and older adults are more susceptible to low sodium.

Stimate can cause the following side effects:

  • Stuffy nose, runny nose, sinus pain, sneezing, and discomfort in the nose
  • Sore throat and cough
  • Dizziness;
  • Increased blood pressure
  • Nausea, stomach cramps;
  • Back pain, headaches, or both?
  • Flushing (warmth, redness, or tingling feeling)

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.

Similar/related drugs

Tranexamic Acid, Desmopressin, DDAVP, Vonvendi, Cyklokapron, Hemlibra, and Antihemophilic Factor

Warnings

Limit your water intake and other fluids. Too much water may cause you to lose sodium and electrolytes, resulting in a dangerous electrolyte balance.

When certain medications are taken together, serious drug interactions may occur. You should tell your doctor if, in addition to the diuretic and steroid medications you are taking, If you experience any of the following symptoms of low sodium: headache, confusion or muscle pain, nausea, loss of appetite, or feeling drowsy, call your doctor immediately.

Before you take this drug

If you have an allergy to Stimate, then it is best not to use Stimate.

You may not be allowed to use Stimate, depending on your health condition.

  • A history of hyponatremia (low sodium levels within your body);
  • Uncontrolled high blood pressure
  • Congestive heart failure;
  • Kidney disease ranging from mild to severe;
  • SIADH (syndrome resulting from inappropriate antidiuretic hormone secretion);
  • Fever, infection, nausea, diarrhea, or any other condition that can cause excessive thirst, dehydration, or electrolyte imbalance

Stimate can interact with some medicines that may cause harmful or unwanted effects. If you use the following medications, your doctor may have to alter your treatment plan:

  • A "loop" (water pill) diuretic: bumetanide, ethacrynic acid, furosemide, or torsemide
  • Subcutaneous, oral, inhaled or injectable steroids such as Budesonide, Dexamethasone, Fluticasone, Mometasone or Prednisone may all help.

If you have nasal or sinus issues (such as a deviated septum), Stimate will be less effective.

Tell your doctor if:

  • Nasal problems, such as a stuffy or runny nose,
  • A psychological disorder that results in extreme or unusual thirst
  • An infection or illness accompanied by fever, vomiting, or diarrhea
  • Congestive heart disease.
  • Kidney disease or inability to urinate
  • A head injury or brain tumor;
  • Cystic Fibrosis

This medicine is not known to harm an unborn child. Inform your physician immediately if you are pregnant or planning to become pregnant. Stimate is not recommended to treat the excessive urination associated with pregnancy.

You may not be able to breastfeed your baby while taking this medication. You should ask your doctor if there are any risks. Do not give this medicine to an infant without consulting with a healthcare provider first.

How to take Stimate nasal?

Stimate may be tested in urine by your doctor to ensure that it is the right medication for you. Read all of the instructions or guides included with your medication and follow them carefully. At times, doctors will change the dose; you must always take it exactly as prescribed. Prime the nasal spray by spraying it four to five times into the air before your first use. Prime the nasal spray again if it hasn't been used for more than three days.

If you experience diarrhea or vomiting that continues, a fever, or excessive sweating, call your doctor. This medicine can cause you to become dehydrated, leading to low pressure and a serious electrolyte imbalance. Your doctor may recommend frequent medical tests and adjust your dosage based on the results. You may need to undergo blood or urine testing before you can start using Stimate again if you have stopped using it.

While using Stimate, limit your water and fluid intake. Too much water could lead to sodium loss. This can lead to an electrolyte imbalance that is life-threatening. Children and older adults who use Stimate should be especially careful about fluid intake. You should follow your doctor's advice about how much liquid you should consume. Store away from moisture or heat at room temperature. When not in use, keep the bottle upright.

Noctiva that has not been opened should be stored in the fridge. Keep the medicine at room temperature after opening and use it within 60 days. Keep the DDAVP nasal tube in your refrigerator. Don't freeze. You can store the bottles closed at room temperature for up to three weeks if refrigeration isn't available. Keep track of the number of sprays that you have used per bottle. Each bottle of desmopressin nasal contains a certain number of sprays.

Even if the medicine is still inside, throw away the spray after you have used the prescribed number of sprays. Pour it out into a fresh bottle. Use this medicine before the date of expiration printed on the label. If Stimate does not stop your bleeding, you should seek medical help.

What happens if I miss the dose?

If you are almost due for your next dose, skip the missed dose. Never take two doses of the same medicine at once.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention. Overdose symptoms include headaches, confusion, drowsiness, or rapid weight gain.

What should be avoided?

Avoid drinking large amounts of liquids before bedtime to help prevent nighttime urination.

Interaction with other drug

Inform your doctor of all the other medications you are taking. Stimate may have interactions with other medications, including:

  • Any other nasal medication
  • Antidepressants are a type of medication.
  • Medications for bladder or urinary problems
  • Cold or allergy medication;
  • A diuretic, or "water pill".
  • Heart or blood pressure medications;
  • Medicine to treat mood disorders, bipolar disorder, or schizophrenia.
  • A steroid medication;
  • Seizure medicine—carbamazepine, lamotrigine,
  • Nsaids are nonsteroidal anti-inflammatory medications (nonsteroidal anti-inflammatory drugs), such as ibuprofen, naproxen, celecoxib (Aleve), diclofenac (indomethacin), meloxicam, and others.

This list is incomplete. Other drugs, such as prescription and non-prescription medicines, vitamins, and herbal products, may also affect Stimate. This list does not include all drug interactions.