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What is Soliqua 100%/33?
Soliqua 100/33 is a combination of lixisenatide and insulin-glargine. Insulin works by lowering the levels of sugar (glucose) in your blood. Insulin glargine, a long-acting form of insulin, begins to work several hours following an injection and continues working for up to 24 hours. Lixisenatide, a diabetes medication that increases the efficiency of your pancreas' insulin production, is used to treat diabetes.
Soliqua 100/33, in conjunction with diet and exercise, is used to improve blood glucose control among adults with type 2 diabetes. Soliqua 100/33 does not treat type I diabetes.
Warnings
If you experience nausea or vomiting and severe pain spreading from your upper stomach to your back, stop using Soliqua immediately and contact your doctor. Do not share an injection pen, syringe, or syringe, even if the needle has been changed.
Before you take this drug
If you've ever had an allergy to insulin, lixisenatide, or both, or if you're allergic to any of these, you should tell your doctor.
- You are experiencing an episode of low blood sugar.
- You can also use a mealtime insulin that is short-acting.
- You can also use lixisenatide (Adlyxin) or a medicine like lixisenatide (albiglutide, dulaglutide, exenatide, liraglutide, Byetta, Bydureon, Saxenda, Tanzeum, Trulicity, and Victoza).
Tell your doctor about any of the following to ensure that Soliqua will be safe for you:
- Pancreatitis, or gallstones.
- Alcoholism;
- Problems digesting food;
- Heart failure;
- Liver or kidney disease
- Low levels of potassium (hypokalemia) in the blood
- Diabetic ketoacidosis (call your doctor for treatment).
Inform your doctor immediately if you are pregnant or nursing. If you're pregnant or plan to become pregnant, follow your doctor's advice about using Soliqua. It is important to control diabetes during pregnancy. High sugar levels can cause complications for both mother and baby.
How to take Soliqua 100/33?
Soliqua 100/33 should be taken exactly as prescribed. Read all the instructions and directions that come with your prescription. Sometimes your doctor will change the dose. Soliqua 100/33 should not be taken in excess of 60 units per day. Soliqua injections are usually given under the skin about an hour before the first meal of the morning. You will be taught how to use the medicine by a healthcare provider.
Please read and follow all instructions for use that come with your medication.If you don't understand the instructions, consult your doctor or pharmacist. Only prepare an injection when you're ready to administer it.If the medicine appears cloudy or has changed colour significantly, or contains particles, do not take it. For new medicine, call your pharmacist. Soliqua should not be injected into skin that has been damaged, tender, or bruised. It also shouldn't be injected into skin that is thickened or scaly.
If you have low blood glucose (hypoglycemia), you may feel very hungry or dizzy. You might also be confused, anxious, or shaky. If you want to treat hyperglycemia quickly, consume or drink sugary foods or drinks (fruit juices, hard candies, crackers, or raisins). In the event of severe hypoglycemia, your doctor may prescribe a glucagon injectable kit. Make sure that your family and friends are familiar with how to administer this injection if you need it in an emergency. Watch for signs of hyperglycemia (high blood sugar), such as increased thirst and urination.
Stress can affect blood sugar levels. Other factors that may influence blood sugar include illness, surgery, or alcohol consumption. Consult your doctor before changing the dose or schedule of your medication. If you experience persistent diarrhea or nausea, call your doctor. Dehydration while taking Soliqua may lead to renal failure. Make sure you drink plenty of water every day. How to store the Soliqua 100/33 Injection Pen that has not been opened (and is not in use): Refrigerate it and keep it away from the light.
Soliqua should not be frozen. If it is, throw the medicine away. Storing an opened (in-use) injection pen Store the pen at room temperature with the cap on (but without the needle), and use it within 28 days. Do not share an injection pen, cartridge, or syringe of Soliqua 100/33 with anyone else, even if you have changed the needle. This can cause an infection or disease to spread from person to person.
Details on dosage
Adult dosage for diabetes type 2:
Insulin glargine (100 units)/lixisenatide (33 mcg/ml; 100/33); the dosage is expressed as insulin glargine units.
Before starting, discontinue the basal insulin or GLP-1 receptor agonist.
For patients who are naive to basal insulin or GLP-1 receptor antagonists, currently on a GLP-1 receptor antagonist, or receiving less than 30 units of basal insulin per day:
Initial dose: 15 subcutaneous units once daily.
Patients receiving 30–60 units of basal insulin with or without a GLP -1 receptor antagonist: Initial Dose: 30 Units Subcutaneously Once a Day
The TITRATE dosage is adjusted in increments between 2 and 4 units/week, based on metabolic requirements, blood glucose monitoring results, and glycemic goals, until the desired fasting plasma sugar is reached.
Maintenance dose: 15–60 units per day.
Maximum dose: insulin glargine 60 units/lixisenatide 20 mcg once a day.
Comments:
Subcutaneously, once daily, within an hour before the first meal.
This drug should be adjusted until the desired fasting blood glucose level is reached.
Additional titration is needed to reduce the risk of hypoglycemia and hyperglycemia, e.g., with changes in activity level, diet, or timing of meals, or during acute illness.
Use: To improve the glycemic level in adults with type 2 diabetes mellitus.
What happens if I miss the dose?
Do not take the missed dose. Use your next dose as usual. Do not take two doses in one go.
What happens if I overdose?
Call the Poison Help Line at 1-800-222-1222 or seek emergency medical care. Overdoses can lead to life-threatening hypoglycemia and hypokalemia (low potassium levels in the blood).
Severe nausea, vomiting, and severe abdominal pain are all symptoms of an overdose.
What should be avoided?
Check the label of your medicine before injecting. Avoid alcohol. Alcohol can cause low sugar levels and interfere with diabetes treatment.
Side effects of Soliqua
If you experience any of the following symptoms of an allergic reaction: itching, severe skin rash, rapid heartbeats, difficulty swallowing, difficult breathing, feeling light-headed, swelling of your lips, face, tongue, or throat, please seek emergency medical attention.
If you experience any of the following symptoms, stop using Soliqua immediately and contact your doctor.
- Pancreatitis: severe pain that spreads to your back and upper stomach; nausea; and vomiting.
- Low sugar; headache; dizziness; rapid heart rate; and feeling anxious.
- Heart problem: swelling, rapid weight increase, feeling of shortness of breath, or
- Low sodium: leg cramps, constipation, increased thirst or urination, numbness, tingling, or muscle weakness.
Soliqua can have a variety of effects, including:
- Low blood sugar
- Nausea, diarrhea;
- Headache
- Cold symptoms like a stuffy nose and sneezing.
There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Interaction with other drug
Inform your doctor if, in addition to pioglitazone and rosiglitazone, you are also taking glimepiride (or metformin). Certain oral diabetes medications can increase the risk of heart problems if you use insulin.
It is possible that lixisenatide will make it more difficult for you to absorb any other medicine taken by mouth. Take any of these medicines at least one hour before you receive your Soliqua injection.
- Anti-biotic
- Acetaminophen; Tylenol
- Birth-control pills (taken 1 hour before or after your Soliqua injection, 100/33).
Other medicines can also affect blood sugar levels and can either increase or decrease insulin glargine or lixisenatide's effects. You may also experience fewer hypoglycemia symptoms if you take certain drugs. This makes it more difficult to detect low blood sugar. Inform your healthcare providers of all the medicines you are taking and those you plan to take. You can include prescription and over-the-counter medicines, vitamins, and herbal products.