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Name of the generic: tolvaptan Tolvaptan tol-VAP-tan tol-VAP-tan
Drug class: Vasopressin antagonists

What is Samsca?

Samsca can be taken orally and decreases the amount of a hormone that regulates the balance between salt and water (sodium) within the body. A high level of this hormone may create an imbalance, resulting in low sodium levels as well as the retention of fluids.Samsca helps treat the condition of hyponatremia (low amounts of sodium present in the blood) in patients with heart insufficiency and other hormonal imbalances.

Samsca enhances the flow of urine without causing the body to lose too much sodium when you flush.This guide to medication contains information on this Samsca version of the drug tolvaptan. Jynarque is a different brand of tolvaptan, which isn't included in this guide.


You shouldn't make use of Samsca when you're dehydrated, cannot go to the bathroom, or cannot discern that you're thirsty.You'll be admitted to a hospital under surveillance whenever you begin or resume treatment.

If you suffer from polycystic renal disease, avoid using Samsca. You must be prescribed a different type that contains tolvaptan (Jynarque) via a specially designed program that monitors the laboratory for your liver.

Samsca is used for treating low sodium levels in the blood; however, it can also be harmful if the problem is reversed too quickly. Contact your doctor immediately when you are experiencing issues with muscles or speech, difficulty swallowing, problems getting your legs and arms moving, as well as confusion or seizures.

Tolvaptan could cause fatal or serious liver issues. Call your doctor immediately if you feel well and you experience upper stomach pain on the right side, vomiting, weight loss, or a yellowing appearance of your eyes or skin.You'll need regular medical tests prior to and throughout your treatments with Samsca.Inform your doctor about your current medications and all the ones you begin or stop taking. A variety of drugs interact, and some medications should not be combined.

Prior to use this drug

It is not recommended to use Samsca. If you have an allergy to tolvaptan, or:

  • If you're in a position to not use the restroom,
  • You're unable to discern you're thirsty;
  • You're dehydrated severely and may feel as if you're about to be ill.

It is not recommended to consume Samsca in the event that your sodium levels need to be raised quickly.

Certain medicines may cause undesirable or hazardous effects when taken in conjunction with Samsca. Your doctor could alter your treatment regimen in the event that you use any of the following:

  • Nefazodone;
  • Is an antibiotic one can use to treat clarithromycin and telithromycin.
  • Antifungal medicine: itraconazole, ketoconazole,
  • HIV/AIDS medication: indinavir, nelfinavir, ritonavir, and saquinavir.

To ensure that Samsca is suitable for you, ask your doctor if you have ever experienced:

  • Kidney disease or urinary tract problems;
  • Problems with the liver;
  • Allergies;
  • If you consume a lot of alcohol,
  • If you are malnourished;
  • If you also take the medication desmopressin (ddavp), diuretics, or "water pill,"

It is not clear if this medication will cause harm to a baby who is not yet born. Inform your doctor if you are expecting.It is not recommended to breastfeed while taking Samsca.

How to take Samsca?

Consume Samsca tablets as recommended by your physician. Follow the instructions on the prescription label and review all medication guides and instructions on the label.Get plenty of fluids while taking Samsca. However, do not drink grapefruit juice or alcohol-based drinks.It is possible to take the tablet without or with food.Samsca is typically taken once each day. Follow the instructions of your physician for dosage extremely carefully.

It is necessary to be monitored in a hospital at any time you begin or resume treatment with Samsca for the purpose of quickly treating any adverse or negative side effects. In the event that you cease taking this medication for any period, you should not begin using it at home.Tolvaptan over a long period of time can cause liver damage. It is recommended not to take this medication for more than 30 days.

It is possible to become dehydrated when you take Samsca, and this can cause serious negative side effects. Contact your doctor if you suffer from persistent diarrhea, vomiting diarrhea, or more sweating than normal.You'll need to take frequent medical examinations.Place it in a cool, dry place far from heat and moisture.

Details on dosage

Usual Adult Dose for Hyponatremia:

Initial dose: 15 mg taken orally at least once per day.
Maintenance dosage: Increase the dose up to 30 mg a day within 24 hours, up to a maximum of 60 mg every day, if needed, to reach the desired level of sodium in the serum.
Maximum dose: 60 mg once a day.
The duration of treatment A maximum of 30 days.

Normal Adult Dose for Hyponatremia Euvolemic:

Initial dosage: 15 mg orally, once a day.
Maintenance dosage: Increase the dose up to 30 mg a day for at least 24 hours, up to a maximum of 60 mg every day, as required to attain the desired amount of sodium in the serum.
Maximum dose: 60 mg once a day.
The duration of therapy is a maximum of 30 days.

During the initiation and titration process, be sure to monitor any changes to serum electrolytes as well as the volume.
Avoid fluid restriction in the very first 24 hours of treatment.
Patients who are taking Samsca must be informed that they are able to continue taking fluids as a response to thirst.
Uses: hypervolemic or euvolemic hyponatremia (serum salt less than 125 meq/L or than a marked hyponatremia that is symptomatic and has not responded to treatment with the restriction of fluids), such as in patients suffering from heart failure as well as the syndrome of inappropriate antidiuretic hormone (SIADH).

What happens if I miss the dose?

Do not take the medication as fast as you can; however, take a break from your missed dosage if you are nearing the time to take the next dose. Don't take two doses at once.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Beware of alcohol-based drinks.

Grapefruit could interact with tolvaptan, which can lead to undesirable reactions. Beware of the use of grapefruit-related products.

Side effects of Samsca

Take immediate medical attention. Get medical attention immediately if you show symptoms of an allergic reaction. Samsca: hives and breathing problems and swelling of your lips, face and tongue.

Contact your doctor immediately. If you are suffering from:

  • Feeling of confusion, weakness, or a lightheaded sensation (like you could be able to pass out);
  • Irregular heartbeats;
  • Unproved weight loss;
  • Signs of dehydration: experiencing extreme thirst or heat,  being unable to urinate, sweating heavily, or having hot or sweaty skin,
  • Liver issues Upper stomach with right-sided nausea, vomiting nausea, loss of appetite The appearance of the skin is becoming yellow or eyesy, and I am not feeling well.

Samsca It is used as a treatment for low blood sodium. However, it can be risky when your sodium levels rise excessively. Contact your doctor or healthcare provider immediately if you exhibit any of the following indications that your hyponatremia is reversing too fast:

  • Difficulties with speech or motor control;
  • Difficulty swallowing
  • Difficulty moving your arms and legs;
  • Mood swings, confusion,
  • A seizure.

Common Samsca adverse reactions could include:

  • Dry mouth;
  • More thirst, or increased urination
  • Fruity breath, hunger;
  • Constipation

This isn't a complete list of all the side effects. Other side effects could be present. Consult your physician to seek medical advice on the effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

It is sometimes not advisable to take certain medicines simultaneously. Certain medications can alter the blood levels of the other drugs that you take, which can create side effects or render the drugs less effective.

A variety of drugs may be incompatible with tolvaptan. Additionally, certain drugs shouldn't be used simultaneously. Discuss with your doctor your current medications as well as any medication you take or stop taking. This includes prescription and over-the-counter medicine, vitamins, and herbal supplements. The interactions between these products are not included in this list.



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