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Repatha Prefilled Syringe

Generic name: evolocumab [E-voe-LOK-ue-mab]

Brand names: Repatha Prefilled Syringe, Repatha Pushtronex, Repatha SureClick, Repatha Autoinjector
Drug class: PCSK9 inhibitors

What is a Repatha Prefilled Syringe?

Repatha Syringe Prefilled works by helping your liver reduce the levels of "bad cholesterol" (low-density lipoprotein, or LDL) circulating in the blood.Repatha prefilled syringes can be used in conjunction with a low-fat diet and other medications to lower cholesterol. This is for people who have homozygous familial hypercholesterolemia or heterozygous high cholesterol. Repatha Prefilled Syringe is used in conjunction with a low-fat diet and other cholesterol-lowering medications for people who have homozygous or heterozygous familial hypercholesterolemia (inherited types of"high cholesterol").A Repatha prefilled syringe can also be used to lower the risk of stroke or heart attacks in patients with heart or blood vessel problems due to plaque buildup or hardening of the arteries.Repatha prefilled syringes can be used in other ways not mentioned in this guide.

Side effects of Repatha Prefilled Syringe

If you experience any of the following: hives; severe itching; difficulty breathing; swelling in your face, lips, or throat;

Repatha prefilled syringes can cause serious side effects. If you experience:

  • High sugar: increased thirst, increased urination, dry mouth, and a fruity breath smell.

Repatha prefilled syringe side effects may include:

  • Redness, pain, or bruising at the site of injection;
  • Backache
  • Flu symptoms
  • Cold symptoms include a stuffy or runny nose.

There may be other side effects. For medical advice on side effects, call your doctor. To report adverse effects, you can contact the FDA at 1-800-FDA-1088.


You should read the entire label and package instructions before taking your medicine. Tell your doctor about any medical conditions you may have, including allergies and medications.

Before you take this drug

Repatha Prefilled Syringe should not be used if you have an allergy to it.

Inform your doctor if you experience any of these symptoms:

  • Liver or kidney disease
  • A latex allergy.

You may find your name on a registry if you are pregnant to track the effects evolocumab has on the baby.Repatha prefilled syringes may cause problems if breast-feeding is being done. You should consult your doctor if you are concerned about any risks.This medicine should not be given to children without consulting a doctor. Repatha prefilled syringes are not for children under 13 years of age. This medicine is not recommended for children under 13 years old if they have certain medical conditions.

How to take Repatha Prefilled Syringe?

Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the label.A Repatha-prefilled syringe is injected into the skin. You may be taught how to use the medication properly by a healthcare provider.Repatha Prefilled Syringe comes in three different forms: a prefilled syringe or autoinjector (SureClick) and a Pushtronex body infusor cartridge. Please read and follow the instructions for use that come with your medicine. If you have any questions, ask your doctor or pharmacist, or call the manufacturer at 1-844-737-2842.Pushtronex is an on-body infusor that slowly delivers the Repatha Prefilled Syringe. Wear the device for approximately 9 minutes in order to receive the full dose. You can walk, bend, and reach while wearing the on-body infusor.Your healthcare provider will show you the best spots on your body where you can inject Repatha prefilled syringes or place the on-body infusor. Each time you inject, use a new location. Don't inject in the same spot twice.

Each prefilled single-use syringe or cartridge is only intended for a single use. Even if some medicine is left in the syringe, throw it away after use. You must follow any local or state laws regarding the disposal of used needles and/or syringes. Use a "sharps container" that is puncture-proof. Be sure to follow local or state laws on how to properly dispose of the container. Keep the container out of reach of pets and children.Repatha Syringe Prefilled should be stored in the original carton in the fridge, away from heat and light. Do not freeze. Do not freeze any of these medicines.Before injecting, remove the medication from the refrigerator. Let it come to room temperature between 30 and 45 minutes. Never heat an injection device or syringe.Repatha Prefilled Syringe can also be stored in its original carton at a cool room temperature away from heat and light. If the medicine is stored at room temperature, it should be used within 30 days.Handle this medication with care. A broken injection device may result from dropping it. Even if there is no visible break, do not use a device that you have dropped on a hard surface. For new medication, call your pharmacist.This medicine should not be shaken. If the color of your medicine has changed or if it has particles, do not use it. For new medication, call your pharmacist.Do not stop using Repatha Prefilled Syringe without consulting your doctor, as your LDL cholesterol level may rise.Repatha Prefilled Syringe is part of a comprehensive treatment program that also includes diet, statin medications, and regular blood tests. You should follow your doctor's advice.

What happens if I miss the dose?

If you miss the dose, use it within seven days. Skip the dose if your missed dose is more than seven days late. If you miss a dose, return to your original schedule. Use the medication again when it is time for your next scheduled dosage.Use only one dose at a time.

What happens if I overdose?

For poison assistance, call 1-800-222-1222 or get immediate medical help.

What should be avoided?

Repatha Prefilled Syringe should not be used on skin that has been bruised, sore, scarred, or hardened.

Interaction with other drug

Repatha Prefilled Syringe may be affected by other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor of all the medicines you are currently taking and those that you will begin or stop using.