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Generic name: repaglinide (oral) [re-PAG-li-nide]
Brand name: Pandin
Oral tablet: (0.5mg, 1 mg, or 2mg)
Class of drugs:Meglitinide

What is Repaglinide?

The use of repaglinide in combination with diet and physical activity can improve the control of blood sugar levels for adults who have type 2 diabetes mellitus. Repaglinide does not treat type 1 diabetes.This medication guide does not list all possible uses for Repaglinide.

Side effects of Repaglinide

If you experience symptoms of a severe allergic reaction, such as hives or difficulty breathing or swelling on your face, throat, or nose, or an extreme skin reaction, including burning eyes or skin, fever, blistering or peeling skin, or skin pain or redness, seek emergency medical attention.

Repaglinide may cause serious side effects. If you experience:

  • If you notice pale, yellowed, or dark urine or if you feel confused or weak, this could be a sign of a fever or confusion.
  • Pancreatitis: severe pain spreading from your stomach to your spine; nausea or vomiting.

Repaglinide can cause the following side effects:

  • Low blood sugar
  • Nausea, diarrhea;
  • Headache, back pain;
  • Joint Pain
  • Cold symptoms like stuffy noses, sneezing, and sore throats.

There may be other side effects. For medical advice on side effects, call your doctor.Call the FDA to report side effects at 1-800-FDA-1088.

Similar/related drugs

Ozempic, Mounjaro, Metformin, Trulicity, Lantus, Victoza, and Tresiba


Repaglinide should be avoided if you suffer from severe liver disease or diabetic ketoacidosis.Repaglinide should not be used with gemfibrozil, NPH insulin, such as isophane, or insulin.

Before you take this drug

Repaglinide should be avoided if:

  • Severe liver disease
  • Diabetic ketoacidosis: Call your doctor to get treated.

Repaglinide can cause interactions with many drugs. Some drugs shouldn't be taken at the same time. If you are also taking

  • Clopidogrel;
  • Cyclosporine;
  • Gemfibrozil;
  • NPH (i.e., isophane) insulin

If you've ever:

  • Liver disease
  • If you are also taking metformin or any other type of diabetes medicine,

If you're pregnant, or if you get pregnant in the future, follow your doctor’s advice about repaglinide.Repaglinide should not be used while breastfeeding.Repaglinide should not be used by those under the age of 18.

How to take Repaglinide?

Follow the instructions in the guide or instruction manual that comes with the medication. Your doctor may change your dose. Take the medicine exactly as directed.Take repaglinide 2–4 times daily within 30 minutes of eating. Please follow your doctor's advice. Repaglinide should not be taken if you miss a meal. Wait until your next meal.You may also need blood tests in your doctor's clinic.If you have hypoglycemia, then you may feel very hungry or dizzy. You might also be confused, anxious, or shaken. If you want to treat hyperglycemia quickly, consume or drink sugary foods or drinks (fruit juices, candy, crackers, or raisins).In the event of severe hypoglycemia, your doctor might prescribe a glucagon injectable kit. Make sure that your close family members or friends are familiar with how to administer this medication in case of an emergency.Watch for symptoms of hyperglycemia, such as an increase in thirst or urine.Stress, illness, surgery, or alcohol consumption can affect blood sugar levels. Consult your doctor before changing the dose of your medication or your schedule.Repaglinide may be part of an overall treatment plan that includes diet, physical activity, weight management, testing for blood sugar, and other medical attention. You should follow your doctor's advice.Repaglinide should be stored at room temperature, away from heat and moisture.

Details on dosage

Adult dosage for diabetes type 2:

Personalize your therapy.
Pre-dose 2, 3, or 4 times per day.
Patients who have not been treated previously with anti-diabetic agents or those whose hemoglobin glycosylation (HbA1c) is below 8%
First dose: 0.5mg orally at each meal.
Patients who have been treated previously with an antidiabetic agent or those whose HbA1c level is 8 or more:
First dose: Take 1 mg orally every meal.
Double the pre-meal dose to 4 mg maximum until a satisfactory response in blood sugar is obtained. Allow at least one week for response assessment after each adjustment.
The recommended dose range is 0.5–4 mg taken orally at each meal.
The maximum daily dose is 16 mg.
In general, fasting blood glucose concentrations (FBG) are used to determine the dose. However, postprandial blood glucose may be prescribed for patients with satisfactory pre-meal glucose but inadequate overall glycemic management (HbA1c).
When hypoglycemia is experienced by patients who are taking this medication in conjunction with metformin or thiazolidinediones, this dose should be decreased.
When used in conjunction with diet and exercise, it can improve the glycemic level of adults who have type II diabetes.

What happens if I miss the dose?

You should take your medication as soon as possible, but only when you're about to have a meal. Skip the dose if you miss a meal and wait for your next meal.

What happens if I overdose?

Call the Poison Help Line at 1-800-222-1222 or seek emergency medical care. Repaglinide can lead to life-threatening hypoglycemia. Call the Poison Help Line at 1-800-222-1222.Severe hypoglycemia can cause extreme weakness, blurred eyesight, sweating, and difficulty speaking. Other symptoms include tremors (convulsions), stomach pains, confusion, and seizures.

What should be avoided?

Alcohol is a depressant and can interfere with your diabetes treatment. Alcohol lowers your blood sugar levels and can interfere with diabetes treatments.

Interaction with other drug

Repaglinide can be affected by other medications. You may also experience a decrease in symptoms, which can make it difficult to detect low blood sugar. It includes all prescription, over-the-counter, and herbal medicines. Inform your healthcare providers of all the medicines that you are currently taking and those you plan to start using.