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Rasuvo (injection)

Generic Name: Methotrexate Injection [meth-oh-TREX-ate] 

Brand Names: Methotrexate Sodium Preserve Free Otrex Rasuvo RediTrex
Drug Classes: Antimetabolites Antipsoriatics Antirheumatics Other immunosuppressants

What is Rasuvo?

Rasuvo can be used with other cancer treatments to treat leukemia, osteosarcoma, and adults and children.Rasuvo can also be used to treat non-Hodgkin lymphoma and meningeal cancer.Rasuvo can be used with other cancer treatments in adult patients to treat gestational tumors and breast tumors.Rasuvo can also be used to treat squamous-cell carcinoma in the head and neck of adults.Rasuvo can also be used to treat severe psoriasis, rheumatoid arthritis, and active polyarticular juvenile idiopathic arthritis.Rasuvo can be used in other ways not mentioned in this guide.

Side effects of Rasuvo

If you experience symptoms of an allergic reaction, such as hives, difficulty breathing, swelling on your face or in your throat, or a severe reaction to the skin (fever or sore throat with burning eyes, burning skin, or blistering skin), seek emergency medical attention.

Rasuvo may cause serious or even fatal side effects. Contact your doctor immediately if:

  • Feeling short of breath, a dry cough, and a sudden pain in the chest;
  • Swollen lymph glands, night sweats, weight loss;
  • Blisters or ulcers on your lips; red or swollen gingiva; difficulty swallowing or feeling thirsty
  • Blood in urine or stools; skin changes like redness, heat, swelling, or oozing
  • Unusual bruising, bleeding, or new signs of illness. (fever, weakness, nausea, diarrhea)
  • Signs of metabolic acidosis include confusion, nausea, and irregular heartbeats.
  • Low blood cell counts: bruising, bleeding, a fever, pale hands and feet, feeling of being light-headed, or feeling short-of-breath;
  • Kidney problems: swelling, decreased urination, fatigue, or feeling short of breath.
  • Liver problems: loss of appetite, pain in the upper right corner of the stomach, fatigue, itching dark urine, clay-colored stools, jaundice
  • Nerve problems: confusion, weakness, sleepiness; coordination problems; feeling irritable; headache; neck stiffness; backache. Vision problems, loss of movement of any part of the body, seizures
  • Signs of cancer cell breakdown include fatigue, weakness, muscle cramps, nausea, vomiting, diarrhea and either an increased or decreased heart rate as well as hand and foot tingling or mouth tingling.

Rasuvo side effects may include:

  • Low blood cell count, fever, chills, and tiredness
  • Headache, nausea, chest pain, difficulty breathing, and dizziness
  • Mouth sores; nausea; vomiting; stomach pains; and diarrhea Runny or stuffy nasal passages, sneezing
  • Abnormal liver function tests
  • Skin lesions, hair fall, rashes, and increased sensitivity to light are all possible.

There may be other side effects.For medical advice regarding side effects, call your doctor. For reporting purposes, the FDA can be reached at 1-800-FDA-1088.

Similar/related drugs

Cosentyx, Stelara, Taltz, Simponi, Olumiant, Trianex, and Sernivo


Rasuvo is not recommended for use during pregnancy in the treatment of arthritis or psoriasis. The medicine injection can be used to treat cancer while pregnant.Inform your physician immediately if you are pregnant or planning to become pregnant.Rasuvo may cause serious or even fatal side effects. Inform your doctor if you have diarrhea, mouth ulcers, shortness of breath, upper stomach discomfort, dark urine, numbness, tingling or muscle weakness, confusion or seizures, or a skin rash with blisters and peeling.

Before you take this drug

Rasuvo should not be used if you have an allergy to it.

Rasuvo is not recommended for the treatment of psoriasis, arthritis, or if you:

  • Alcoholism or cirrhosis.
  • An impaired blood cell or weak immune system are among the major threats facing humanity today.
  • If you are breastfeeding or pregnant,

Rasuvo can be used to treat cancer in people with the conditions listed above. This treatment will be decided by your doctor.

Inform your physician of any of the following issues:

  • Kidney disease (or dialysis if you have it);
  • Fluid buildup in the stomach (ascites) and fluid accumulation around your lungs
  • A stomach ulcer, or colitis ulcerative
  • History of neurological problems, such as seizures
  • Any type of infection
  • Radiation treatment
  • Alcoholism is a serious problem.
  • If you are planning to undergo any surgery with general anesthesia, including dental surgery,

Before you begin using Rasuvo, make sure that you have received all of your vaccines. Inform your doctor if a recent vaccine was received or if a booster is scheduled.Rasuvo may harm an unborn child if either the mother or father uses it. The medicine injection can affect the fertility of men and women. This medicine could make it harder for either parent to get pregnant. Inform your doctor if you are pregnant.

  • You may need to take a pregnancy test if you're a woman. Use birth control during treatment and for 6 months following your last dose.
  • Use birth control if you're a man and your partner can get pregnant. Continue to use birth control at least three months after your last dose.

After taking this medication, do not breastfeed for one week.

How to take Rasuvo?

Read all the instructions or guides that come with your medication and follow the directions. Sometimes, your doctor will change the dose. Take your medication exactly as instructed.Rasuvo should be taken once a week. Do not use this medication more than prescribed.Follow your doctor's directions when it comes to dosage.The dose is based on the body surface area. You may need to adjust your dose if you lose or gain weight, or if you are still growing.Rasuvo can be injected under the skin or into a vein. You will be given this injection by a healthcare provider, who may also teach you how to use it properly.Rasuvo can be injected into the thigh or stomach when treating arthritis or psoriasis. Avoid injecting within two inches of the navel, arms, other body parts, or any area where the skin appears to be tender, bruised, red, hard, or with stretch marks or scars.

Only prepare an injection when you're ready to administer it. If the medicine is cloudy or has changed color, call your pharmacist.Never reuse a needle, syringe, or auto-injector. Put them in a "sharps container" that is puncture-proof, and dispose of the container according to local or state laws.Your next dose could be delayed, depending on the results of your medical tests.Rasuvo can increase your risk of developing other cancers. This is something you should discuss with your doctor.Rasuvo comes with instructions on how to store the medicine. You can get more information from your pharmacist about how to store the medicine.

What happens if I miss the dose?

If you have forgotten to take your Rasuvo home or missed your appointment, call your doctor.

What happens if I overdose?

Call Poison Help at 1-800-222-1222 or seek emergency medical care. A methotrexate overdose can be fatal.

What should be avoided?

Rasuvo can cause you to burn more quickly. Avoid tanning beds or sunlight. When you're outdoors, wear protective clothing and use sunblock (SPF 30 or higher).Avoid alcohol. Alcohol can cause liver damage.You could get a serious infection if you receive a "live vaccine". Live vaccines are measles, mumps, rubella (MMR), rotavirus, typhoid (yellow fever), typhoid (typhoid), varicella (chickenpox), and zoster (shingles).You should avoid driving or other hazardous activities until you are sure of how Your ability to react properly may be hindered.

Interaction with other drug

Tell your doctor about your other medications, including:

  • An antibiotic or sulfa-drug, mercaptopurine (nitrous oxide), phenytoin (probenecid), dapsone (pyrimethamine),
  • Aspirin, naproxen, celecoxib (Aleve), diclofenac (Indomethacin), indomethacin (meloxicam), and other NSAIDs;
  • There are various medications used to reduce stomach acidity - esomeprazole, lansoprazole, omeprazole, pantoprazole (Nexium, Prilosec Protonix etc).

This list isn't complete. Many other drugs can affect Rasuvo. This includes over-the-counter and prescription medicines, vitamins, and herbal products. This list does not provide all possible drug interactions.